Neuromuscular Junction Disorders

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Questions and Answers

Which of the following is a common symptom of myasthenia gravis?

  • Difficulty with swallowing (correct)
  • Difficulty with articulation
  • Difficulty walking up stairs
  • Difficulty lifting objects above head-level

What is the purpose of the ice-pack test in diagnosing myasthenia gravis?

  • To observe improvement in ptosis (correct)
  • To detect acetylcholine receptor antibodies
  • To rule out thymoma
  • To measure muscle strength

Which antibodies are found in 85% of patients with myasthenia gravis?

  • Muscle specific receptor tyrosine kinase antibodies
  • Autoantibodies
  • Acetylcholine receptor antibodies (correct)
  • Thymoma antibodies

What is the initial therapy for myasthenia gravis?

<p>Pyridostigmine (B)</p> Signup and view all the answers

Which treatment option is used if pyridostigmine does not work for myasthenia gravis?

<p>Glucocorticoids (D)</p> Signup and view all the answers

What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

<p>To bind to anti-ACH receptor antibodies and clear them out of the system (A)</p> Signup and view all the answers

What is the recommended treatment for a patient with myasthenia gravis and thymoma?

<p>Thymectomy (A)</p> Signup and view all the answers

What is the purpose of a chest CT scan in myasthenia gravis?

<p>To rule out thymoma (B)</p> Signup and view all the answers

Which of the following is a symptom of myasthenia gravis crisis?

<p>Respiratory failure (B)</p> Signup and view all the answers

What is the purpose of repetitive nerve stimulation in diagnosing myasthenia gravis?

<p>To measure muscle strength (A)</p> Signup and view all the answers

Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?

<p>Botulism (D)</p> Signup and view all the answers

Which disorder is caused by auto-antibodies at the post-synaptic junction?

<p>Myasthenia Gravis (MG) (B)</p> Signup and view all the answers

Which disorder is caused by auto-antibodies at the pre-synaptic junction?

<p>Lambert Eaton myasthenic syndrome (LEMS) (C)</p> Signup and view all the answers

Which disorder is characterized by the cleavage of SNARE proteins by a neurotoxin?

<p>Botulism (B)</p> Signup and view all the answers

Which disorder can be caused by home canned food or open wounds?

<p>Botulism (A)</p> Signup and view all the answers

Which disorder is associated with auto-antibodies targeting pre-synaptic junctions?

<p>Lambert Eaton myasthenic syndrome (LEMS) (A)</p> Signup and view all the answers

Which disorder is characterized by reduced stimulation of nicotinic receptors?

<p>Myasthenia Gravis (MG) (D)</p> Signup and view all the answers

Which disorder is associated with organophosphate exposure?

<p>Organophosphate exposure (OE) (C)</p> Signup and view all the answers

Which disorder is characterized by auto-antibodies at the post-synaptic junction?

<p>Myasthenia Gravis (MG) (A)</p> Signup and view all the answers

Which disorder is caused by Clostridium botulinum neurotoxin?

<p>Botulism (C)</p> Signup and view all the answers

Which of the following is a clinical feature of myasthenia gravis?

<p>Ptosis and diplopia (A)</p> Signup and view all the answers

What is the most common symptom of myasthenia gravis?

<p>Ptosis and diplopia (D)</p> Signup and view all the answers

Which of the following is a characteristic of ocular myasthenia gravis?

<p>Pure ocular symptoms (D)</p> Signup and view all the answers

What is the cause of myasthenia gravis?

<p>Autoimmune destruction of acetylcholine receptors (D)</p> Signup and view all the answers

Which of the following is an associated condition with myasthenia gravis?

<p>Hyperthyroidism (D)</p> Signup and view all the answers

What diagnostic study is commonly used for myasthenia gravis?

<p>Repetitive nerve stimulation (A)</p> Signup and view all the answers

What is the treatment for myasthenia gravis crisis?

<p>IVIg or PE (B)</p> Signup and view all the answers

Which type of neuron is affected in myasthenia gravis?

<p>Lower motor neuron (A)</p> Signup and view all the answers

What is the normal physiology of the neuromuscular junction?

<p>Action potential triggers vesicle exocytosis (B)</p> Signup and view all the answers

Which step in the normal physiology of the neuromuscular junction involves the activation of nicotinic acetylcholine receptors on the postsynaptic membrane?

<p>Acetylcholine release into synaptic cleft (C)</p> Signup and view all the answers

Which disorder is characterized by auto-antibodies at the pre-synaptic junction?

<p>Lambert Eaton myasthenic syndrome (LEMS) (B)</p> Signup and view all the answers

What is the cause of Myasthenia Gravis (MG)?

<p>Auto-antibodies at the post-synaptic junction (B)</p> Signup and view all the answers

Which disorder is associated with organophosphate exposure?

<p>Organophosphate exposure (OE) (A)</p> Signup and view all the answers

What is the purpose of repetitive nerve stimulation in diagnosing Myasthenia Gravis (MG)?

<p>To detect abnormal muscle responses (C)</p> Signup and view all the answers

Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?

<p>Botulism (D)</p> Signup and view all the answers

Which disorder can be caused by home canned food or open wounds?

<p>Botulism (B)</p> Signup and view all the answers

What is the initial therapy for Myasthenia Gravis (MG)?

<p>Pyridostigmine (C)</p> Signup and view all the answers

What is the recommended treatment for a patient with Myasthenia Gravis (MG) and thymoma?

<p>Thymectomy (A)</p> Signup and view all the answers

Which disorder is associated with auto-antibodies targeting pre-synaptic junctions?

<p>Lambert Eaton myasthenic syndrome (LEMS) (D)</p> Signup and view all the answers

What diagnostic study is commonly used for Myasthenia Gravis (MG)?

<p>Electromyography (EMG) (D)</p> Signup and view all the answers

Which of the following is a clinical feature of myasthenia gravis?

<p>Peripheral and central muscarinic stimulation (A)</p> Signup and view all the answers

What is the purpose of the ice-pack test in diagnosing myasthenia gravis?

<p>To differentiate between myasthenia gravis and other neuromuscular disorders (B)</p> Signup and view all the answers

Which disorder is characterized by the cleavage of SNARE proteins by a neurotoxin?

<p>Botulism (B)</p> Signup and view all the answers

What is the recommended treatment for a patient with myasthenia gravis and thymoma?

<p>Thymectomy (C)</p> Signup and view all the answers

Which disorder is caused by Clostridium botulinum neurotoxin?

<p>Botulism (D)</p> Signup and view all the answers

What is the purpose of repetitive nerve stimulation in diagnosing myasthenia gravis?

<p>To demonstrate a decremental response in muscle action potentials (C)</p> Signup and view all the answers

Which disorder is associated with auto-antibodies targeting pre-synaptic junctions?

<p>Lambert-Eaton myasthenic syndrome (C)</p> Signup and view all the answers

Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?

<p>Lambert-Eaton myasthenic syndrome (B)</p> Signup and view all the answers

What is the purpose of a chest CT scan in myasthenia gravis?

<p>To detect the presence of a thymoma (C)</p> Signup and view all the answers

Which of the following is an associated condition with myasthenia gravis?

<p>Hyperthyroidism (B)</p> Signup and view all the answers

Which muscles are weakened in myasthenia gravis?

<p>Muscles of one eye (A)</p> Signup and view all the answers

What is the main reason for seeing two images in myasthenia gravis?

<p>Improper alignment of images in the brain (D)</p> Signup and view all the answers

What are the bulbar symptoms associated with myasthenia gravis?

<p>Difficulty with articulation and swallowing (D)</p> Signup and view all the answers

Which diagnostic study is used to observe the improvement of symptoms with an ice-pack?

<p>Ice-pack test (C)</p> Signup and view all the answers

What is the purpose of the Tensilon (edrophonium) test in diagnosing myasthenia gravis?

<p>To inhibit acetylcholinesterase and improve symptoms (B)</p> Signup and view all the answers

Which antibodies are found in 85% of patients with myasthenia gravis?

<p>Acetylcholine receptor antibodies (AchR-Ab) (D)</p> Signup and view all the answers

What is the initial therapy for myasthenia gravis?

<p>Pyridostigmine (B)</p> Signup and view all the answers

What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

<p>To clear out anti-ACH receptor antibodies (B)</p> Signup and view all the answers

What is the recommended treatment for a patient with myasthenia gravis and thymoma?

<p>Thymectomy (A)</p> Signup and view all the answers

What is the cause of myasthenia gravis?

<p>Autoantibodies at the neuromuscular junction (C)</p> Signup and view all the answers

Which of the following is a clinical feature of myasthenia gravis?

<p>Muscle weakness in descending order (B)</p> Signup and view all the answers

What is the most common symptom of myasthenia gravis?

<p>Ptosis (C)</p> Signup and view all the answers

Which of the following is an associated condition with myasthenia gravis?

<p>Hyperthyroidism (C)</p> Signup and view all the answers

What diagnostic study is commonly used for myasthenia gravis?

<p>Ice-pack test (D)</p> Signup and view all the answers

What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

<p>To improve muscle strength (A)</p> Signup and view all the answers

What is the cause of Myasthenia Gravis (MG)?

<p>Autoimmune destruction of nicotinic acetylcholine receptors (D)</p> Signup and view all the answers

Which disorder is caused by Clostridium botulinum neurotoxin?

<p>Botulism (B)</p> Signup and view all the answers

What is the recommended treatment for a patient with myasthenia gravis and thymoma?

<p>Thymectomy (D)</p> Signup and view all the answers

What diagnostic study is commonly used for Myasthenia Gravis (MG)?

<p>Repetitive nerve stimulation (B)</p> Signup and view all the answers

Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?

<p>Lambert-Eaton myasthenic syndrome (A)</p> Signup and view all the answers

Which disorder is caused by auto-antibodies at the post-synaptic junction?

<p>Myasthenia Gravis (MG) (D)</p> Signup and view all the answers

What is the main reason for seeing two images in myasthenia gravis?

<p>Reduced stimulation of nicotinic and muscarinic receptors (C)</p> Signup and view all the answers

Which disorder is associated with organophosphate exposure?

<p>Organophosphate exposure (OE) (C)</p> Signup and view all the answers

What is the normal physiology of the neuromuscular junction?

<p>Proper communication between nerve and muscle cells (A)</p> Signup and view all the answers

What is the cause of myasthenia gravis?

<p>Auto-antibodies at the post-synaptic junction (A)</p> Signup and view all the answers

What is the recommended treatment for a patient with myasthenia gravis and thymoma?

<p>Immunosuppressive therapy (A)</p> Signup and view all the answers

Which diagnostic study is used to observe the improvement of symptoms with an ice-pack?

<p>Ice-pack test (B)</p> Signup and view all the answers

Which disorder is characterized by auto-antibodies at the pre-synaptic junction?

<p>Lambert Eaton myasthenic syndrome (LEMS) (D)</p> Signup and view all the answers

What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

<p>To improve muscle strength (A)</p> Signup and view all the answers

What are the bulbar symptoms associated with myasthenia gravis?

<p>Difficulty swallowing and speaking (A)</p> Signup and view all the answers

Which of the following is a common symptom of myasthenia gravis?

<p>Difficulty swallowing (D)</p> Signup and view all the answers

What is the purpose of the Tensilon (edrophonium) test in diagnosing myasthenia gravis?

<p>To assess the response to acetylcholinesterase inhibitor (B)</p> Signup and view all the answers

What diagnostic study is commonly used for myasthenia gravis?

<p>Autoantibody test (A)</p> Signup and view all the answers

What is the recommended treatment for a patient with myasthenia gravis and thymoma?

<p>Thymectomy (C)</p> Signup and view all the answers

What is the main reason for seeing two images in myasthenia gravis?

<p>Improper alignment of images in the brain (A)</p> Signup and view all the answers

What is the purpose of the ice-pack test in diagnosing myasthenia gravis?

<p>To observe the improvement of symptoms with an ice-pack (B)</p> Signup and view all the answers

Which disorder is caused by autoantibodies at the post-synaptic junction?

<p>Myasthenia gravis (C)</p> Signup and view all the answers

Which diagnostic study is used to observe the improvement of symptoms with an ice-pack?

<p>Tensilon (edrophonium) test (D)</p> Signup and view all the answers

Which disorder is associated with autoantibodies targeting pre-synaptic junctions?

<p>Lambert-Eaton myasthenic syndrome (D)</p> Signup and view all the answers

What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

<p>To clear anti-ACH receptor antibodies from the system (D)</p> Signup and view all the answers

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