Neuromuscular Junction Disorders
90 Questions
8 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following is a common symptom of myasthenia gravis?

  • Difficulty with swallowing (correct)
  • Difficulty with articulation
  • Difficulty walking up stairs
  • Difficulty lifting objects above head-level

    • What is the purpose of the ice-pack test in diagnosing myasthenia gravis?

  • To observe improvement in ptosis (correct)
  • To detect acetylcholine receptor antibodies
  • To rule out thymoma
  • To measure muscle strength

    • Which antibodies are found in 85% of patients with myasthenia gravis?

  • Muscle specific receptor tyrosine kinase antibodies
  • Autoantibodies
  • Acetylcholine receptor antibodies (correct)
  • Thymoma antibodies

    • What is the initial therapy for myasthenia gravis?

    <p>Pyridostigmine</p> Signup and view all the answers

    Which treatment option is used if pyridostigmine does not work for myasthenia gravis?

    <p>Glucocorticoids</p> Signup and view all the answers

    What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

    <p>To bind to anti-ACH receptor antibodies and clear them out of the system</p> Signup and view all the answers

    What is the recommended treatment for a patient with myasthenia gravis and thymoma?

    <p>Thymectomy</p> Signup and view all the answers

    What is the purpose of a chest CT scan in myasthenia gravis?

    <p>To rule out thymoma</p> Signup and view all the answers

    Which of the following is a symptom of myasthenia gravis crisis?

    <p>Respiratory failure</p> Signup and view all the answers

    What is the purpose of repetitive nerve stimulation in diagnosing myasthenia gravis?

    <p>To measure muscle strength</p> Signup and view all the answers

    Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?

    <p>Botulism</p> Signup and view all the answers

    Which disorder is caused by auto-antibodies at the post-synaptic junction?

    <p>Myasthenia Gravis (MG)</p> Signup and view all the answers

    Which disorder is caused by auto-antibodies at the pre-synaptic junction?

    <p>Lambert Eaton myasthenic syndrome (LEMS)</p> Signup and view all the answers

    Which disorder is characterized by the cleavage of SNARE proteins by a neurotoxin?

    <p>Botulism</p> Signup and view all the answers

    Which disorder can be caused by home canned food or open wounds?

    <p>Botulism</p> Signup and view all the answers

    Which disorder is associated with auto-antibodies targeting pre-synaptic junctions?

    <p>Lambert Eaton myasthenic syndrome (LEMS)</p> Signup and view all the answers

    Which disorder is characterized by reduced stimulation of nicotinic receptors?

    <p>Myasthenia Gravis (MG)</p> Signup and view all the answers

    Which disorder is associated with organophosphate exposure?

    <p>Organophosphate exposure (OE)</p> Signup and view all the answers

    Which disorder is characterized by auto-antibodies at the post-synaptic junction?

    <p>Myasthenia Gravis (MG)</p> Signup and view all the answers

    Which disorder is caused by Clostridium botulinum neurotoxin?

    <p>Botulism</p> Signup and view all the answers

    Which of the following is a clinical feature of myasthenia gravis?

    <p>Ptosis and diplopia</p> Signup and view all the answers

    What is the most common symptom of myasthenia gravis?

    <p>Ptosis and diplopia</p> Signup and view all the answers

    Which of the following is a characteristic of ocular myasthenia gravis?

    <p>Pure ocular symptoms</p> Signup and view all the answers

    What is the cause of myasthenia gravis?

    <p>Autoimmune destruction of acetylcholine receptors</p> Signup and view all the answers

    Which of the following is an associated condition with myasthenia gravis?

    <p>Hyperthyroidism</p> Signup and view all the answers

    What diagnostic study is commonly used for myasthenia gravis?

    <p>Repetitive nerve stimulation</p> Signup and view all the answers

    What is the treatment for myasthenia gravis crisis?

    <p>IVIg or PE</p> Signup and view all the answers

    Which type of neuron is affected in myasthenia gravis?

    <p>Lower motor neuron</p> Signup and view all the answers

    What is the normal physiology of the neuromuscular junction?

    <p>Action potential triggers vesicle exocytosis</p> Signup and view all the answers

    Which step in the normal physiology of the neuromuscular junction involves the activation of nicotinic acetylcholine receptors on the postsynaptic membrane?

    <p>Acetylcholine release into synaptic cleft</p> Signup and view all the answers

    Which disorder is characterized by auto-antibodies at the pre-synaptic junction?

    <p>Lambert Eaton myasthenic syndrome (LEMS)</p> Signup and view all the answers

    What is the cause of Myasthenia Gravis (MG)?

    <p>Auto-antibodies at the post-synaptic junction</p> Signup and view all the answers

    Which disorder is associated with organophosphate exposure?

    <p>Organophosphate exposure (OE)</p> Signup and view all the answers

    What is the purpose of repetitive nerve stimulation in diagnosing Myasthenia Gravis (MG)?

    <p>To detect abnormal muscle responses</p> Signup and view all the answers

    Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?

    <p>Botulism</p> Signup and view all the answers

    Which disorder can be caused by home canned food or open wounds?

    <p>Botulism</p> Signup and view all the answers

    What is the initial therapy for Myasthenia Gravis (MG)?

    <p>Pyridostigmine</p> Signup and view all the answers

    What is the recommended treatment for a patient with Myasthenia Gravis (MG) and thymoma?

    <p>Thymectomy</p> Signup and view all the answers

    Which disorder is associated with auto-antibodies targeting pre-synaptic junctions?

    <p>Lambert Eaton myasthenic syndrome (LEMS)</p> Signup and view all the answers

    What diagnostic study is commonly used for Myasthenia Gravis (MG)?

    <p>Electromyography (EMG)</p> Signup and view all the answers

    Which of the following is a clinical feature of myasthenia gravis?

    <p>Peripheral and central muscarinic stimulation</p> Signup and view all the answers

    What is the purpose of the ice-pack test in diagnosing myasthenia gravis?

    <p>To differentiate between myasthenia gravis and other neuromuscular disorders</p> Signup and view all the answers

    Which disorder is characterized by the cleavage of SNARE proteins by a neurotoxin?

    <p>Botulism</p> Signup and view all the answers

    What is the recommended treatment for a patient with myasthenia gravis and thymoma?

    <p>Thymectomy</p> Signup and view all the answers

    Which disorder is caused by Clostridium botulinum neurotoxin?

    <p>Botulism</p> Signup and view all the answers

    What is the purpose of repetitive nerve stimulation in diagnosing myasthenia gravis?

    <p>To demonstrate a decremental response in muscle action potentials</p> Signup and view all the answers

    Which disorder is associated with auto-antibodies targeting pre-synaptic junctions?

    <p>Lambert-Eaton myasthenic syndrome</p> Signup and view all the answers

    Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?

    <p>Lambert-Eaton myasthenic syndrome</p> Signup and view all the answers

    What is the purpose of a chest CT scan in myasthenia gravis?

    <p>To detect the presence of a thymoma</p> Signup and view all the answers

    Which of the following is an associated condition with myasthenia gravis?

    <p>Hyperthyroidism</p> Signup and view all the answers

    Which muscles are weakened in myasthenia gravis?

    <p>Muscles of one eye</p> Signup and view all the answers

    What is the main reason for seeing two images in myasthenia gravis?

    <p>Improper alignment of images in the brain</p> Signup and view all the answers

    What are the bulbar symptoms associated with myasthenia gravis?

    <p>Difficulty with articulation and swallowing</p> Signup and view all the answers

    Which diagnostic study is used to observe the improvement of symptoms with an ice-pack?

    <p>Ice-pack test</p> Signup and view all the answers

    What is the purpose of the Tensilon (edrophonium) test in diagnosing myasthenia gravis?

    <p>To inhibit acetylcholinesterase and improve symptoms</p> Signup and view all the answers

    Which antibodies are found in 85% of patients with myasthenia gravis?

    <p>Acetylcholine receptor antibodies (AchR-Ab)</p> Signup and view all the answers

    What is the initial therapy for myasthenia gravis?

    <p>Pyridostigmine</p> Signup and view all the answers

    What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

    <p>To clear out anti-ACH receptor antibodies</p> Signup and view all the answers

    What is the recommended treatment for a patient with myasthenia gravis and thymoma?

    <p>Thymectomy</p> Signup and view all the answers

    What is the cause of myasthenia gravis?

    <p>Autoantibodies at the neuromuscular junction</p> Signup and view all the answers

    Which of the following is a clinical feature of myasthenia gravis?

    <p>Muscle weakness in descending order</p> Signup and view all the answers

    What is the most common symptom of myasthenia gravis?

    <p>Ptosis</p> Signup and view all the answers

    Which of the following is an associated condition with myasthenia gravis?

    <p>Hyperthyroidism</p> Signup and view all the answers

    What diagnostic study is commonly used for myasthenia gravis?

    <p>Ice-pack test</p> Signup and view all the answers

    What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

    <p>To improve muscle strength</p> Signup and view all the answers

    What is the cause of Myasthenia Gravis (MG)?

    <p>Autoimmune destruction of nicotinic acetylcholine receptors</p> Signup and view all the answers

    Which disorder is caused by Clostridium botulinum neurotoxin?

    <p>Botulism</p> Signup and view all the answers

    What is the recommended treatment for a patient with myasthenia gravis and thymoma?

    <p>Thymectomy</p> Signup and view all the answers

    What diagnostic study is commonly used for Myasthenia Gravis (MG)?

    <p>Repetitive nerve stimulation</p> Signup and view all the answers

    Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?

    <p>Lambert-Eaton myasthenic syndrome</p> Signup and view all the answers

    Which disorder is caused by auto-antibodies at the post-synaptic junction?

    <p>Myasthenia Gravis (MG)</p> Signup and view all the answers

    What is the main reason for seeing two images in myasthenia gravis?

    <p>Reduced stimulation of nicotinic and muscarinic receptors</p> Signup and view all the answers

    Which disorder is associated with organophosphate exposure?

    <p>Organophosphate exposure (OE)</p> Signup and view all the answers

    What is the normal physiology of the neuromuscular junction?

    <p>Proper communication between nerve and muscle cells</p> Signup and view all the answers

    What is the cause of myasthenia gravis?

    <p>Auto-antibodies at the post-synaptic junction</p> Signup and view all the answers

    What is the recommended treatment for a patient with myasthenia gravis and thymoma?

    <p>Immunosuppressive therapy</p> Signup and view all the answers

    Which diagnostic study is used to observe the improvement of symptoms with an ice-pack?

    <p>Ice-pack test</p> Signup and view all the answers

    Which disorder is characterized by auto-antibodies at the pre-synaptic junction?

    <p>Lambert Eaton myasthenic syndrome (LEMS)</p> Signup and view all the answers

    What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

    <p>To improve muscle strength</p> Signup and view all the answers

    What are the bulbar symptoms associated with myasthenia gravis?

    <p>Difficulty swallowing and speaking</p> Signup and view all the answers

    Which of the following is a common symptom of myasthenia gravis?

    <p>Difficulty swallowing</p> Signup and view all the answers

    What is the purpose of the Tensilon (edrophonium) test in diagnosing myasthenia gravis?

    <p>To assess the response to acetylcholinesterase inhibitor</p> Signup and view all the answers

    What diagnostic study is commonly used for myasthenia gravis?

    <p>Autoantibody test</p> Signup and view all the answers

    What is the recommended treatment for a patient with myasthenia gravis and thymoma?

    <p>Thymectomy</p> Signup and view all the answers

    What is the main reason for seeing two images in myasthenia gravis?

    <p>Improper alignment of images in the brain</p> Signup and view all the answers

    What is the purpose of the ice-pack test in diagnosing myasthenia gravis?

    <p>To observe the improvement of symptoms with an ice-pack</p> Signup and view all the answers

    Which disorder is caused by autoantibodies at the post-synaptic junction?

    <p>Myasthenia gravis</p> Signup and view all the answers

    Which diagnostic study is used to observe the improvement of symptoms with an ice-pack?

    <p>Tensilon (edrophonium) test</p> Signup and view all the answers

    Which disorder is associated with autoantibodies targeting pre-synaptic junctions?

    <p>Lambert-Eaton myasthenic syndrome</p> Signup and view all the answers

    What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?

    <p>To clear anti-ACH receptor antibodies from the system</p> Signup and view all the answers

    Study Notes

    Iassistant<|start_header_id|>assistantassistantassistant

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Disorders of the Neuromuscular Junction PDF

    Description

    Test your knowledge on disorders of the neuromuscular junction with this quiz. Explore topics such as Myasthenia Gravis (MG), Lambert Eaton myasthenic syndrome (LEMS), and Botulism. Prepare for your exam by reviewing important information provided by Dr. Tariq Alfahad. Good luck!

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser