90 Questions
Which of the following is a common symptom of myasthenia gravis?
Difficulty with swallowing
What is the purpose of the ice-pack test in diagnosing myasthenia gravis?
To observe improvement in ptosis
Which antibodies are found in 85% of patients with myasthenia gravis?
Acetylcholine receptor antibodies
What is the initial therapy for myasthenia gravis?
Pyridostigmine
Which treatment option is used if pyridostigmine does not work for myasthenia gravis?
Glucocorticoids
What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?
To bind to anti-ACH receptor antibodies and clear them out of the system
What is the recommended treatment for a patient with myasthenia gravis and thymoma?
Thymectomy
What is the purpose of a chest CT scan in myasthenia gravis?
To rule out thymoma
Which of the following is a symptom of myasthenia gravis crisis?
Respiratory failure
What is the purpose of repetitive nerve stimulation in diagnosing myasthenia gravis?
To measure muscle strength
Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?
Botulism
Which disorder is caused by auto-antibodies at the post-synaptic junction?
Myasthenia Gravis (MG)
Which disorder is caused by auto-antibodies at the pre-synaptic junction?
Lambert Eaton myasthenic syndrome (LEMS)
Which disorder is characterized by the cleavage of SNARE proteins by a neurotoxin?
Botulism
Which disorder can be caused by home canned food or open wounds?
Botulism
Which disorder is associated with auto-antibodies targeting pre-synaptic junctions?
Lambert Eaton myasthenic syndrome (LEMS)
Which disorder is characterized by reduced stimulation of nicotinic receptors?
Myasthenia Gravis (MG)
Which disorder is associated with organophosphate exposure?
Organophosphate exposure (OE)
Which disorder is characterized by auto-antibodies at the post-synaptic junction?
Myasthenia Gravis (MG)
Which disorder is caused by Clostridium botulinum neurotoxin?
Botulism
Which of the following is a clinical feature of myasthenia gravis?
Ptosis and diplopia
What is the most common symptom of myasthenia gravis?
Ptosis and diplopia
Which of the following is a characteristic of ocular myasthenia gravis?
Pure ocular symptoms
What is the cause of myasthenia gravis?
Autoimmune destruction of acetylcholine receptors
Which of the following is an associated condition with myasthenia gravis?
Hyperthyroidism
What diagnostic study is commonly used for myasthenia gravis?
Repetitive nerve stimulation
What is the treatment for myasthenia gravis crisis?
IVIg or PE
Which type of neuron is affected in myasthenia gravis?
Lower motor neuron
What is the normal physiology of the neuromuscular junction?
Action potential triggers vesicle exocytosis
Which step in the normal physiology of the neuromuscular junction involves the activation of nicotinic acetylcholine receptors on the postsynaptic membrane?
Acetylcholine release into synaptic cleft
Which disorder is characterized by auto-antibodies at the pre-synaptic junction?
Lambert Eaton myasthenic syndrome (LEMS)
What is the cause of Myasthenia Gravis (MG)?
Auto-antibodies at the post-synaptic junction
Which disorder is associated with organophosphate exposure?
Organophosphate exposure (OE)
What is the purpose of repetitive nerve stimulation in diagnosing Myasthenia Gravis (MG)?
To detect abnormal muscle responses
Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?
Botulism
Which disorder can be caused by home canned food or open wounds?
Botulism
What is the initial therapy for Myasthenia Gravis (MG)?
Pyridostigmine
What is the recommended treatment for a patient with Myasthenia Gravis (MG) and thymoma?
Thymectomy
Which disorder is associated with auto-antibodies targeting pre-synaptic junctions?
Lambert Eaton myasthenic syndrome (LEMS)
What diagnostic study is commonly used for Myasthenia Gravis (MG)?
Electromyography (EMG)
Which of the following is a clinical feature of myasthenia gravis?
Peripheral and central muscarinic stimulation
What is the purpose of the ice-pack test in diagnosing myasthenia gravis?
To differentiate between myasthenia gravis and other neuromuscular disorders
Which disorder is characterized by the cleavage of SNARE proteins by a neurotoxin?
Botulism
What is the recommended treatment for a patient with myasthenia gravis and thymoma?
Thymectomy
Which disorder is caused by Clostridium botulinum neurotoxin?
Botulism
What is the purpose of repetitive nerve stimulation in diagnosing myasthenia gravis?
To demonstrate a decremental response in muscle action potentials
Which disorder is associated with auto-antibodies targeting pre-synaptic junctions?
Lambert-Eaton myasthenic syndrome
Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?
Lambert-Eaton myasthenic syndrome
What is the purpose of a chest CT scan in myasthenia gravis?
To detect the presence of a thymoma
Which of the following is an associated condition with myasthenia gravis?
Hyperthyroidism
Which muscles are weakened in myasthenia gravis?
Muscles of one eye
What is the main reason for seeing two images in myasthenia gravis?
Improper alignment of images in the brain
What are the bulbar symptoms associated with myasthenia gravis?
Difficulty with articulation and swallowing
Which diagnostic study is used to observe the improvement of symptoms with an ice-pack?
Ice-pack test
What is the purpose of the Tensilon (edrophonium) test in diagnosing myasthenia gravis?
To inhibit acetylcholinesterase and improve symptoms
Which antibodies are found in 85% of patients with myasthenia gravis?
Acetylcholine receptor antibodies (AchR-Ab)
What is the initial therapy for myasthenia gravis?
Pyridostigmine
What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?
To clear out anti-ACH receptor antibodies
What is the recommended treatment for a patient with myasthenia gravis and thymoma?
Thymectomy
What is the cause of myasthenia gravis?
Autoantibodies at the neuromuscular junction
Which of the following is a clinical feature of myasthenia gravis?
Muscle weakness in descending order
What is the most common symptom of myasthenia gravis?
Ptosis
Which of the following is an associated condition with myasthenia gravis?
Hyperthyroidism
What diagnostic study is commonly used for myasthenia gravis?
Ice-pack test
What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?
To improve muscle strength
What is the cause of Myasthenia Gravis (MG)?
Autoimmune destruction of nicotinic acetylcholine receptors
Which disorder is caused by Clostridium botulinum neurotoxin?
Botulism
What is the recommended treatment for a patient with myasthenia gravis and thymoma?
Thymectomy
What diagnostic study is commonly used for Myasthenia Gravis (MG)?
Repetitive nerve stimulation
Which disorder is characterized by reduced stimulation of nicotinic and muscarinic receptors?
Lambert-Eaton myasthenic syndrome
Which disorder is caused by auto-antibodies at the post-synaptic junction?
Myasthenia Gravis (MG)
What is the main reason for seeing two images in myasthenia gravis?
Reduced stimulation of nicotinic and muscarinic receptors
Which disorder is associated with organophosphate exposure?
Organophosphate exposure (OE)
What is the normal physiology of the neuromuscular junction?
Proper communication between nerve and muscle cells
What is the cause of myasthenia gravis?
Auto-antibodies at the post-synaptic junction
What is the recommended treatment for a patient with myasthenia gravis and thymoma?
Immunosuppressive therapy
Which diagnostic study is used to observe the improvement of symptoms with an ice-pack?
Ice-pack test
Which disorder is characterized by auto-antibodies at the pre-synaptic junction?
Lambert Eaton myasthenic syndrome (LEMS)
What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?
To improve muscle strength
What are the bulbar symptoms associated with myasthenia gravis?
Difficulty swallowing and speaking
Which of the following is a common symptom of myasthenia gravis?
Difficulty swallowing
What is the purpose of the Tensilon (edrophonium) test in diagnosing myasthenia gravis?
To assess the response to acetylcholinesterase inhibitor
What diagnostic study is commonly used for myasthenia gravis?
Autoantibody test
What is the recommended treatment for a patient with myasthenia gravis and thymoma?
Thymectomy
What is the main reason for seeing two images in myasthenia gravis?
Improper alignment of images in the brain
What is the purpose of the ice-pack test in diagnosing myasthenia gravis?
To observe the improvement of symptoms with an ice-pack
Which disorder is caused by autoantibodies at the post-synaptic junction?
Myasthenia gravis
Which diagnostic study is used to observe the improvement of symptoms with an ice-pack?
Tensilon (edrophonium) test
Which disorder is associated with autoantibodies targeting pre-synaptic junctions?
Lambert-Eaton myasthenic syndrome
What is the purpose of IV immunoglobulin (IVIg) or plasma exchange (PE) in managing myasthenia gravis crisis?
To clear anti-ACH receptor antibodies from the system
Study Notes
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Test your knowledge on disorders of the neuromuscular junction with this quiz. Explore topics such as Myasthenia Gravis (MG), Lambert Eaton myasthenic syndrome (LEMS), and Botulism. Prepare for your exam by reviewing important information provided by Dr. Tariq Alfahad. Good luck!
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