Mechanism of Action of Morphine and Opioid Receptors

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What is the primary mechanism of action for morphine and related opioid compounds?

Stimulation of adrenergic receptors in the central nervous system

Activation of the gamma-aminobutyric acid (GABA) system in the brain

Inhibition of acetylcholine release in the peripheral nervous system

Stimulation of opioid receptors in the central and peripheral tissues (correct)

Which of the following is NOT a characteristic effect of morphine's action on mu-opioid receptors?

Miosis (pupillary constriction)

Euphoria

Respiratory depression

Increased gastrointestinal motility (correct)

Which endogenous opioid peptide is LEAST likely to bind to and activate kappa-opioid receptors?

Endorphin

Substance P (correct)

Dynorphin

Enkephalin

How do the effects of morphine on mu-opioid receptors and kappa-opioid receptors differ?

Mu-opioid receptor activation has a greater effect on the brain, while kappa-opioid receptor activation has a greater effect on the spinal cord. Signup and view all the answers

What is the primary mechanism by which morphine and related opioids induce hypothermia?

Inhibition of the heat regulatory center in the brain Signup and view all the answers

Which of the following is the LEAST likely mechanism by which opioid receptors mediate their analgesic effects?

Activation of the sympathetic nervous system Signup and view all the answers

Mechanism of Action of Morphine and Opioid Receptors

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Questions and Answers

What is the primary mechanism of action for morphine and related opioid compounds?

Which of the following is NOT a characteristic effect of morphine's action on mu-opioid receptors?

Which endogenous opioid peptide is LEAST likely to bind to and activate kappa-opioid receptors?

How do the effects of morphine on mu-opioid receptors and kappa-opioid receptors differ?

What is the primary mechanism by which morphine and related opioids induce hypothermia?

Which of the following is the LEAST likely mechanism by which opioid receptors mediate their analgesic effects?

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