Irritable Bowel Syndrome and Chronic Idiopathic Constipation

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Listen to an AI-generated conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

What is the mechanism of action of diphenoxylate + atropine (Lomotil)?

  • Adsorbs intestinal toxins and microorganisms
  • Inhibits excessive GI motility and GI propulsion (correct)
  • Modifies fluid and electrolyte transport
  • Inhibits circular and longitudinal intestinal muscles through the opioid receptor

What is the most common side effect of adsorbents used to treat diarrhea?

  • Dizziness
  • Nausea
  • Euphoria
  • Constipation (correct)

What is the main concern associated with the use of bismuth subsalicylate (Pepto-Bismol) in children?

  • Tongue discoloration
  • Fecal discoloration
  • Nausea
  • Cannot be given to children (correct)

What is the primary cause of infectious diarrhea caused by Clostridioides difficile?

<p>Exposure to antibiotics (C)</p>
Signup and view all the answers

What is the mechanism of action of metronidazole (Flagyl) in treating Clostridioides difficile infection?

<p>Inhibits bacterial cell wall synthesis (B)</p>
Signup and view all the answers

What is the main side effect of bezlotoxumab (Zinplava) used for preventing recurrence of C. difficile infection?

<p>Worsening heart failure (B)</p>
Signup and view all the answers

What is the drug of choice for treating irritable bowel syndrome (IBS)?

<p>Continue the drug of choice as long as side effects are not an issue and remission is maintained (B)</p>
Signup and view all the answers

Which one of the following is considered a functional GI disorder?

<p>Irritable bowel syndrome (IBS) (B)</p>
Signup and view all the answers

What is the socioeconomic impact of irritable bowel syndrome (IBS) according to the text?

<p>Considerable (A)</p>
Signup and view all the answers

How is irritable bowel syndrome (IBS) subtyped according to predominant bowel habit?

<p>Based on the patient’s description of stool form by referring to the Bristol Stool Scale (D)</p>
Signup and view all the answers

Which type of irritable bowel syndrome (IBS) is characterized by a predominant bowel habit of constipation?

<p>IBS with constipation (IBS-C) (B)</p>
Signup and view all the answers

What is the common characteristic of irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC)?

<p>Not associated with abnormal radiologic or endoscopic abnormalities or a reliable biomarker (D)</p>
Signup and view all the answers

What are the main objectives of integrating knowledge about drugs used to treat diarrhea?

<p>Appropriate use of these drugs (C)</p>
Signup and view all the answers

What can cause diarrhea besides bacterial or viral infection?

<p>Decreased GI motility (D)</p>
Signup and view all the answers

How can antidiarrheals be classified?

<p>As anti-motility, adsorbents, and fluid/electrolyte modifiers (D)</p>
Signup and view all the answers

Which condition does NOT relate to the objectives mentioned in the text?

<p>Infectious diarrhea (B)</p>
Signup and view all the answers

What is the main focus of integrating knowledge about drugs used to treat inflammatory bowel disease?

<p>Understanding the mechanisms of action of these drugs (C)</p>
Signup and view all the answers

Which category of antidiarrheals modifies fluid and electrolyte transport?

<p>Anti-motility agents (D)</p>
Signup and view all the answers

Which medication is a chloride channel activator that increases intestinal fluid secretion and intestinal motility?

<p>Lubiprostone (D)</p>
Signup and view all the answers

What is the mechanism of action of Plecanatide (Trulance)?

<p>Agonizes guanylate cyclase-C on the luminal surface of intestinal epithelium (A)</p>
Signup and view all the answers

Which medication is a potent antagonist of 5-HT3 and reduces pain, abdominal discomfort, urgency, and diarrhea?

<p>Alosetron (D)</p>
Signup and view all the answers

What is the main concern regarding the use of Eluxadoline (Viberzi)?

<p>Cannot be used in severe liver impairment (D)</p>
Signup and view all the answers

Which medication acts as a sodium/hydrogen exchanger 3 inhibitor, reducing sodium absorption from the small intestine and colon?

<p>Tenapanor (A)</p>
Signup and view all the answers

What is the most common side effect associated with Linaclotide (Linzess)?

<p>Diarrhea (B)</p>
Signup and view all the answers

What is the MOA of topical mesalamine?

<p>Modulation of local chemical mediators of the inflammatory response (C)</p>
Signup and view all the answers

Which medication is given IV with diphenhydramine and acetaminophen premedication?

<p>Infliximab (C)</p>
Signup and view all the answers

What is the main concern with the use of azathioprine and 6-mercaptopurine?

<p>Toxicity in individuals with low thiopurine methyltransferase activity (B)</p>
Signup and view all the answers

Which medication specifically blocks the interaction of T-lymphocytes with MAdCAM-1?

<p>Vedolizumab (B)</p>
Signup and view all the answers

Which medication inhibits Janus kinase?

<p>Tofacitinib (B)</p>
Signup and view all the answers

What is the MOA of sulfasalazine?

<p>Modulation of local chemical mediators of the inflammatory response (C)</p>
Signup and view all the answers

What is the mechanism of action of sulfamethoxazole + trimethoprim (Bactrim)?

<p>Sequential inhibition of enzymes of the folic acid pathway (C)</p>
Signup and view all the answers

Which antibiotic should be avoided in neonates?

<p>Ciprofloxacin (Cipro) (B)</p>
Signup and view all the answers

What is the common side effect of metronidazole (Flagyl)?

<p>Diarrhea (A)</p>
Signup and view all the answers

Which antibiotic combination is used for inpatient treatment of diverticulitis?

<p>Metronidazole plus Ciprofloxacin or Levofloxacin or Cefotaxime (B)</p>
Signup and view all the answers

What is the mechanism of action of Ceftriaxone (Rocephin)?

<p>Inhibits bacterial cell wall synthesis by binding to one or more penicillin-binding proteins (PBPs) (D)</p>
Signup and view all the answers

What are the common side effects of Piperacillin-Tazobactam (Zosyn)?

<p>Rash, diarrhea, nausea, vomiting, injection site reaction (A)</p>
Signup and view all the answers

What is the mechanism of action of Imipenem-cilastatin (Primaxin I.V.)?

<p>Inhibits bacterial cell wall synthesis by binding to one or more penicillin-binding proteins (PBPs) (D)</p>
Signup and view all the answers

What should be avoided while taking Ciprofloxacin and Levofloxacin?

<p>Multivitamins, calcium, iron, or dairy products (C)</p>
Signup and view all the answers

What is the common side effect of Ampicillin + sulbactam (Unasyn)?

<p>Rash, diarrhea, thrombophlebitis (B)</p>
Signup and view all the answers

Which antibiotic is not suitable for use in children?

<p>Imipenem-cilastatin (Primaxin I.V.) (B)</p>
Signup and view all the answers

Flashcards are hidden until you start studying

Related Documents

4 - Intestines_student2024.ppt

More Like This

Use Quizgecko on...
Browser
Browser