Treatment of Irritable Bowel Syndrome with GI Medications
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Questions and Answers

What is the primary reason for Tenapanor (Ibsrela) being contraindicated in patients?

  • It leads to dizziness and syncope
  • It inhibits the absorption of dietary sodium (correct)
  • It causes severe diarrhea
  • It is not present in breastmilk

    • Which adverse effect has been reported in some cases associated with Linacotide use?

  • Severe diarrhea requiring IV fluids (correct)
  • Hypertension and tachycardia
  • Bradypnea and bronchoconstriction
  • Dizziness and syncope

    • What is a key benefit of Tenapanor (Ibsrela) in the treatment of IBS-C?

  • Reduces abdominal pain (correct)
  • Increases visceral hypersensitivity
  • Blocks absorption of water
  • Induces constipation

    • Why should the decision to breastfeed during therapy with Linacotide be carefully considered?

    <p>Considering the risk of infant exposure and benefits to both the infant and mother</p> Signup and view all the answers

    What does Tenapanor target to achieve its therapeutic effect in IBS-C?

    <p>Sodium/hydrogen exchanger isoform 3</p> Signup and view all the answers

    Which of the following statements about Linacotide is true?

    <p>It has no significant drug interactions</p> Signup and view all the answers

    What is the mechanism of action of Tenapanor (Ibsrela) in blocking sodium absorption?

    <p>Blocking sodium/hydrogen exchanger isoform 3</p> Signup and view all the answers

    Why is careful consideration needed for the decision to breastfeed during Tenapanor therapy?

    <p>Considering the risk of infant exposure, benefits of breastfeeding to infant, and treatment benefits to mother</p> Signup and view all the answers

    What is the primary goal of using antispasmodic drugs in the treatment of IBS?

    <p>Reduce symptoms by increasing colonic transit time</p> Signup and view all the answers

    Which of the following is NOT a common anticholinergic side effect associated with antispasmodic drugs?

    <p>Hyperthermia</p> Signup and view all the answers

    How do serotonin 5-HT-3 receptor antagonists work in the treatment of IBS?

    <p>Modulate visceral sensation and motility</p> Signup and view all the answers

    What led to alosetron being taken off the market in 2000?

    <p>Safety concerns including ischemic colitis and complicated constipation</p> Signup and view all the answers

    Under what strategy was alosetron reintroduced to the market in 2002?

    <p>Risk evaluation and mitigation strategy (REMS)</p> Signup and view all the answers

    What is a common adverse effect associated with linaclotide, a guanylate cyclase-C agonist?

    <p>Diarrhea</p> Signup and view all the answers

    Why is linaclotide contraindicated in pediatric patients younger than 2 years?

    <p>Risk of serious dehydration</p> Signup and view all the answers

    What is the US Boxed Warning for Tenapanor (Ibsrela)?

    <p>Associated with severe diarrhea and electrolyte abnormalities</p> Signup and view all the answers

    Which of the following is a potential drug interaction associated with Linacotide?

    <p>Reduced absorption when taken with antacids</p> Signup and view all the answers

    What is a significant warning associated with the use of Linacotide?

    <p>Reports of syncope and hypotension</p> Signup and view all the answers

    Which adverse effect has NOT been reported with the use of Linacotide?

    <p>Hypertension</p> Signup and view all the answers

    What is a concern related to the use of Linacotide during breastfeeding?

    <p>Potential transmission of gastrointestinal infection to the infant</p> Signup and view all the answers

    Which statement best describes the FDA indications for Linacotide?

    <p>Indicated for use in adults only with IBS-C</p> Signup and view all the answers

    Why is careful monitoring required when using Linacotide?

    <p>To prevent electrolyte imbalances and dehydration</p> Signup and view all the answers

    What is the FDA indication for linaclotide?

    <p>Chronic idiopathic constipation</p> Signup and view all the answers

    Which of the following is a US boxed warning associated with linaclotide?

    <p>Risk of severe dehydration in pediatric patients</p> Signup and view all the answers

    Which type of patients should linaclotide be reserved for?

    <p>Patients with persistent constipation despite laxative use</p> Signup and view all the answers

    What is a potential adverse effect associated with linaclotide use?

    <p>Headache</p> Signup and view all the answers

    Which of the following is NOT a common drug interaction associated with linaclotide?

    <p>Antibiotics</p> Signup and view all the answers

    Why is linaclotide contraindicated in pediatric patients younger than 2 years?

    <p>It may lead to dehydration</p> Signup and view all the answers

    What is a common adverse effect of linaclotide that can sometimes be severe?

    <p>Abdominal pain</p> Signup and view all the answers

    Which of the following is a notable warning associated with linaclotide use?

    <p>'May mask symptoms of serious conditions'</p> Signup and view all the answers

    What is the most concerning potential adverse effect associated with linaclotide use?

    <p>Severe diarrhea with dizziness and syncope</p> Signup and view all the answers

    In terms of drug interactions, which statement accurately reflects the known interactions with linaclotide?

    <p>No significant drug interactions are currently known</p> Signup and view all the answers

    What is the FDA indication for linaclotide use?

    <p>Approved for treatment of IBS-C in adults only</p> Signup and view all the answers

    What is the US Boxed Warning associated with Tenapanor (Ibsrela)?

    <p>Contraindicated in pediatric patients</p> Signup and view all the answers

    Which of the following is a possible adverse effect requiring hospitalization in some cases of linaclotide use?

    <p>Severe diarrhea with electrolyte abnormalities</p> Signup and view all the answers

    Why should the decision to breastfeed during treatment with linaclotide be carefully considered?

    <p>The risk of infant exposure and benefits of breastfeeding need to be weighed against the benefits of treatment to the mother</p> Signup and view all the answers

    Which of the following accurately describes a concern related to linaclotide use during breastfeeding?

    <p>'It can expose the infant to the drug, requiring careful consideration'</p> Signup and view all the answers

    What is a potential adverse effect of linaclotide that is sometimes severe?

    <p>Diarrhea</p> Signup and view all the answers

    Which of the following is not a common drug interaction associated with linaclotide?

    <p>Antidiarrheal agents</p> Signup and view all the answers

    What is a notable warning associated with linaclotide use?

    <p>Risk of serious dehydration in pediatric patients under 2 years old</p> Signup and view all the answers

    What is a significant adverse effect reported in some cases associated with linaclotide use?

    <p>Intestinal discomfort and pain</p> Signup and view all the answers

    Which of the following statements about linaclotide is true?

    <p>It targets guanylate cyclase-C receptors to reduce intestinal fluid secretion</p> Signup and view all the answers

    What is the FDA indication for linaclotide?

    <p>IBS-C and chronic idiopathic constipation in adults</p> Signup and view all the answers

    What is the US boxed warning for linaclotide?

    <p>'Black box' warning for potential life-threatening diarrhea</p> Signup and view all the answers

    Why is careful monitoring required when using linaclotide?

    <p>'Black box' warning for severe dehydration in pediatric patients under 2 years old</p> Signup and view all the answers

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