Treatment of Irritable Bowel Syndrome with GI Medications

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Questions and Answers

What is the primary reason for Tenapanor (Ibsrela) being contraindicated in patients?

It leads to dizziness and syncope
It inhibits the absorption of dietary sodium (correct)
It causes severe diarrhea
It is not present in breastmilk

Which adverse effect has been reported in some cases associated with Linacotide use?

Severe diarrhea requiring IV fluids (correct)
Hypertension and tachycardia
Bradypnea and bronchoconstriction
Dizziness and syncope

What is a key benefit of Tenapanor (Ibsrela) in the treatment of IBS-C?

Reduces abdominal pain (correct)
Increases visceral hypersensitivity
Blocks absorption of water
Induces constipation

Why should the decision to breastfeed during therapy with Linacotide be carefully considered?

Considering the risk of infant exposure and benefits to both the infant and mother (A) Signup and view all the answers

What does Tenapanor target to achieve its therapeutic effect in IBS-C?

Sodium/hydrogen exchanger isoform 3 (A) Signup and view all the answers

Which of the following statements about Linacotide is true?

It has no significant drug interactions (B) Signup and view all the answers

What is the mechanism of action of Tenapanor (Ibsrela) in blocking sodium absorption?

Blocking sodium/hydrogen exchanger isoform 3 (B) Signup and view all the answers

Why is careful consideration needed for the decision to breastfeed during Tenapanor therapy?

Considering the risk of infant exposure, benefits of breastfeeding to infant, and treatment benefits to mother (D) Signup and view all the answers

What is the primary goal of using antispasmodic drugs in the treatment of IBS?

Reduce symptoms by increasing colonic transit time (A) Signup and view all the answers

Which of the following is NOT a common anticholinergic side effect associated with antispasmodic drugs?

Hyperthermia (A) Signup and view all the answers

How do serotonin 5-HT-3 receptor antagonists work in the treatment of IBS?

Modulate visceral sensation and motility (C) Signup and view all the answers

What led to alosetron being taken off the market in 2000?

Safety concerns including ischemic colitis and complicated constipation (B) Signup and view all the answers

Under what strategy was alosetron reintroduced to the market in 2002?

Risk evaluation and mitigation strategy (REMS) (B) Signup and view all the answers

What is a common adverse effect associated with linaclotide, a guanylate cyclase-C agonist?

Diarrhea (C) Signup and view all the answers

Why is linaclotide contraindicated in pediatric patients younger than 2 years?

Risk of serious dehydration (A) Signup and view all the answers

What is the US Boxed Warning for Tenapanor (Ibsrela)?

Associated with severe diarrhea and electrolyte abnormalities (C) Signup and view all the answers

Which of the following is a potential drug interaction associated with Linacotide?

Reduced absorption when taken with antacids (D) Signup and view all the answers

What is a significant warning associated with the use of Linacotide?

Reports of syncope and hypotension (A) Signup and view all the answers

Which adverse effect has NOT been reported with the use of Linacotide?

Hypertension (C) Signup and view all the answers

What is a concern related to the use of Linacotide during breastfeeding?

Potential transmission of gastrointestinal infection to the infant (A) Signup and view all the answers

Which statement best describes the FDA indications for Linacotide?

Indicated for use in adults only with IBS-C (A) Signup and view all the answers

Why is careful monitoring required when using Linacotide?

To prevent electrolyte imbalances and dehydration (C) Signup and view all the answers

What is the FDA indication for linaclotide?

Chronic idiopathic constipation (A) Signup and view all the answers

Which of the following is a US boxed warning associated with linaclotide?

Risk of severe dehydration in pediatric patients (B) Signup and view all the answers

Which type of patients should linaclotide be reserved for?

Patients with persistent constipation despite laxative use (B) Signup and view all the answers

What is a potential adverse effect associated with linaclotide use?

Headache (C) Signup and view all the answers

Which of the following is NOT a common drug interaction associated with linaclotide?

Antibiotics (A) Signup and view all the answers

Why is linaclotide contraindicated in pediatric patients younger than 2 years?

It may lead to dehydration (D) Signup and view all the answers

What is a common adverse effect of linaclotide that can sometimes be severe?

Abdominal pain (D) Signup and view all the answers

Which of the following is a notable warning associated with linaclotide use?

'May mask symptoms of serious conditions' (B) Signup and view all the answers

What is the most concerning potential adverse effect associated with linaclotide use?

Severe diarrhea with dizziness and syncope (D) Signup and view all the answers

In terms of drug interactions, which statement accurately reflects the known interactions with linaclotide?

No significant drug interactions are currently known (D) Signup and view all the answers

What is the FDA indication for linaclotide use?

Approved for treatment of IBS-C in adults only (B) Signup and view all the answers

What is the US Boxed Warning associated with Tenapanor (Ibsrela)?

Contraindicated in pediatric patients (C) Signup and view all the answers

Which of the following is a possible adverse effect requiring hospitalization in some cases of linaclotide use?

Severe diarrhea with electrolyte abnormalities (B) Signup and view all the answers

Why should the decision to breastfeed during treatment with linaclotide be carefully considered?

The risk of infant exposure and benefits of breastfeeding need to be weighed against the benefits of treatment to the mother (B) Signup and view all the answers

Which of the following accurately describes a concern related to linaclotide use during breastfeeding?

'It can expose the infant to the drug, requiring careful consideration' (B) Signup and view all the answers

What is a potential adverse effect of linaclotide that is sometimes severe?

Diarrhea (B) Signup and view all the answers

Which of the following is not a common drug interaction associated with linaclotide?

Antidiarrheal agents (D) Signup and view all the answers

What is a notable warning associated with linaclotide use?

Risk of serious dehydration in pediatric patients under 2 years old (D) Signup and view all the answers

What is a significant adverse effect reported in some cases associated with linaclotide use?

Intestinal discomfort and pain (A) Signup and view all the answers

Which of the following statements about linaclotide is true?

It targets guanylate cyclase-C receptors to reduce intestinal fluid secretion (B) Signup and view all the answers

What is the FDA indication for linaclotide?

IBS-C and chronic idiopathic constipation in adults (C) Signup and view all the answers

What is the US boxed warning for linaclotide?

'Black box' warning for potential life-threatening diarrhea (D) Signup and view all the answers

Why is careful monitoring required when using linaclotide?

'Black box' warning for severe dehydration in pediatric patients under 2 years old (A) Signup and view all the answers

Flashcards

Tenapanor contraindication

Inhibits dietary sodium absorption, leading to potential complications.

Linaclotide adverse effect

Severe diarrhea requiring IV fluids.