Irritable Bowel Syndrome and Chronic Idiopathic Constipation

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Questions and Answers

What are the three categories of antidiarrheal medications mentioned in the text?

  • Anti-motility, adsorbents, and agents that modify fluid and electrolyte transport (correct)
  • Anti-inflammatory, analgesics, and corticosteroids
  • Antacids, laxatives, and proton pump inhibitors
  • Antibiotics, probiotics, and antivirals

What is a common cause of noninfectious diarrhea mentioned in the text?

  • Viral infection
  • Fluid absorption from the gut
  • Bacterial infection
  • Increased GI motility (correct)

What is the objective of integrating knowledge about drugs used to treat irritable bowel syndrome?

  • To understand mechanisms of action of antibiotics
  • To increase awareness about viral infection
  • To promote the use of laxatives
  • To ensure appropriate use of drugs for irritable bowel syndrome (correct)

Which condition can drugs be used to treat based on the objectives mentioned in the text?

<p>Diverticulitis (A)</p> Signup and view all the answers

What is the main focus of integrating knowledge about drugs used to treat inflammatory bowel disease?

<p>To ensure appropriate use of drugs for inflammatory bowel disease (A)</p> Signup and view all the answers

What can cause diarrhea besides bacterial or viral infection according to the text?

<p>Stress and anxiety (A)</p> Signup and view all the answers

Which of the following is an appropriate concern when using diphenoxylate + atropine (Lomotil) for diarrhea treatment?

<p>Treatment of infectious diarrhea (C)</p> Signup and view all the answers

What is the main concern associated with the use of loperamide (Immodium A-D) for diarrhea treatment?

<p>Treatment of infectious diarrhea (A)</p> Signup and view all the answers

What is a common side effect associated with adsorbents used for diarrhea treatment?

<p>Fecal discoloration (C)</p> Signup and view all the answers

What is the main concern regarding the use of bismuth subsalicylate (Pepto-Bismol) for diarrhea treatment?

<p>Usage in children (A)</p> Signup and view all the answers

Which class of antibiotics has a high association with causing C. difficile infection?

<p>Cephalosporins (B)</p> Signup and view all the answers

What is the treatment of choice for C. difficile infection, which interacts with DNA to cause inhibition of protein synthesis and cell death?

<p>Metronidazole (Flagyl) (D)</p> Signup and view all the answers

What is the mechanism of action of 6-Mercaptopurine (Purixan) in the treatment of ulcerative colitis?

<p>Inhibition of DNA and RNA synthesis (D)</p> Signup and view all the answers

What is the main concern when using Azathioprine (Imuran) for the treatment of ulcerative colitis?

<p>Test for thiopurine methyltransferase (TPMT) activity (D)</p> Signup and view all the answers

Which medication is contraindicated in patients with heart failure due to an increased risk for infection and TB?

<p>Adalimumab (Humira) (C)</p> Signup and view all the answers

What is the mechanism of action of Methotrexate in the treatment of Crohn’s disease?

<p>Folate antimetabolite that inhibits DNA synthesis, repair, and cellular replication (D)</p> Signup and view all the answers

Which biologic agent is a monoclonal antibody that binds to the alpha-4 subunit of integrin molecules that prevents transmigration of leukocytes?

<p>Natalizumab (Tysabri) (A)</p> Signup and view all the answers

What is the main concern when using Tofacitinib (Xeljanz) for the treatment of ulcerative colitis?

<p>CYP3A4 interactions (D)</p> Signup and view all the answers

What is the mechanism of action of Lubiprostone?

<p>Agonist of guanylate cyclase-C (A)</p> Signup and view all the answers

Which medication is limited to women with severe diarrhea-predominant IBS due to concerns about ischemic colitis?

<p>Linaclotide (Linzess) (A)</p> Signup and view all the answers

What is the main side effect of Plecanatide (Trulance)?

<p>Abdominal distension (C)</p> Signup and view all the answers

What is the mechanism of action of Eluxadoline (Viberzi)?

<p>Mixed mu-opioid receptor agonist (B)</p> Signup and view all the answers

What is the most common side effect of Bisacodyl (Dulcolax)?

<p>Bloating (B)</p> Signup and view all the answers

What is the MOA of Prucalopride (Motegrity)?

<p>Selective, high affinity 5-HT4 receptor agonist promoting cholinergic neurotransmission by enteric neurons (C)</p> Signup and view all the answers

What are the two most common functional GI disorders worldwide?

<p>Irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC) (A)</p> Signup and view all the answers

What is the basis for subtyping IBS?

<p>Predominant bowel habit (A)</p> Signup and view all the answers

According to the text, what is the socioeconomic impact of IBS?

<p>Considerable impact due to associated debility and prevalence (D)</p> Signup and view all the answers

What is the basis for classifying IBS according to bowel habit type?

<p>Stool form described by the patient using the Bristol Stool Scale (B)</p> Signup and view all the answers

How is chronic idiopathic constipation (CIC) characterized?

<p>Not associated with abnormal radiologic or endoscopic abnormalities or a reliable biomarker (C)</p> Signup and view all the answers

In what age group does IBS typically occur?

<p>Younger adulthood (B)</p> Signup and view all the answers

What is the mechanism of action of sulfamethoxazole + trimethoprim (Bactrim)?

<p>Sequential inhibition of enzymes of the folic acid pathway (D)</p> Signup and view all the answers

What is the most common side effect of ciprofloxacin (Cipro)?

<p>Dizziness (A)</p> Signup and view all the answers

Which antibiotic should be avoided in patients with a history of seizures?

<p>Meropenem (Merrem) (D)</p> Signup and view all the answers

Which antibiotic combination is commonly used for inpatient treatment of diverticulitis?

<p>Metronidazole plus Ciprofloxacin (A)</p> Signup and view all the answers

What is the primary concern with the use of sulfamethoxazole + trimethoprim (Bactrim) in neonates?

<p>Do NOT given to neonates (A)</p> Signup and view all the answers

Which antibiotic inhibits bacterial cell wall synthesis by binding one or more penicillin-binding proteins (PBPs)?

<p>Cefotaxime (Claforan) (D)</p> Signup and view all the answers

What is the most common side effect of metronidazole (Flagyl)?

<p>Metallic taste (C)</p> Signup and view all the answers

What is the primary concern with the use of metronidazole (Flagyl)?

<p>NO ALCOHOL while taking and for 3 days after stopping the medication (B)</p> Signup and view all the answers

Which antibiotic should be used for diverticulitis inpatient treatment if the patient is allergic to penicillin?

<p>Ciprofloxacin (B)</p> Signup and view all the answers

What is the appropriate antipseudomonal penicillin for diverticulitis inpatient treatment?

<p>Piperacillin-Tazobactam (B)</p> Signup and view all the answers

Which antibiotic combination is suitable for diverticulitis inpatient treatment for Pseudomonas coverage?

<p>Ciprofloxacin + Metronidazole (B)</p> Signup and view all the answers

Which antibiotic should be avoided in neonates with diverticulitis?

<p>Ceftriaxone (B)</p> Signup and view all the answers

What is the correct antibiotic regimen for outpatient treatment of uncomplicated diverticulitis?

<p>Amoxicillin/Clavulanate alone (B)</p> Signup and view all the answers

Which antibiotic should not be taken with multivitamins, calcium, iron, or dairy products?

<p>Ciprofloxacin (C)</p> Signup and view all the answers

What is the antibiotic of choice for diverticulitis inpatient treatment if the patient has a history of seizures?

<p>Meropenem (B)</p> Signup and view all the answers

What is the appropriate antibiotic regimen for diverticulitis inpatient treatment if the patient has renal impairment?

<p>Piperacillin-Tazobactam + Cefotaxime (D)</p> Signup and view all the answers

Which antibiotic should be avoided in children for the treatment of diverticulitis?

<p>Ciprofloxacin (A)</p> Signup and view all the answers

Which antibiotic has a disulfiram-like reaction as a potential side effect?

<p>Metronidazole (D)</p> Signup and view all the answers

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