16 Questions
What is the primary function of RIG-like receptors (RLRs)?
Producing type I interferons
Which cytosolic proteins recognize viral RNA and induce the production of type I interferons?
RIG-I
Where is the NLRP3 inflammasome expressed in the body?
In the skin and other cells
What is one of the ways inflammasome activation is tightly controlled?
Post-translational modifications
Which receptor family uses NLRP3 as a sensor?
NOD-like receptor family
What is the function of NLRP3 inflammasome?
Activating inflammatory processes
What is the primary role of RIG-like receptors (RLRs)?
To recognize viral RNA
Which pathway is activated in response to cytosolic DNA?
STING pathway
Where do RIG-like receptors (RLRs) signal through interactions with?
Mitochondrial membrane
What is involved in the STING pathway?
cGAMP binding to STING on the endoplasmic reticulum
What does RIG-like receptor (RLR) activation lead to?
Production of type I interferons
Apart from type I interferon production, what is another function of the STING pathway?
Induction of autophagy
What is the enzyme that activates the production of a cyclic dinucleotide signaling molecule in the STING pathway?
cGAS
Where is the stimulator of interferon gene (STING) located?
Endoplasmic reticulum membrane
What happens when STING binds cyclic dinucleotides?
Transcriptional activation and expression of type I IFN genes occur
What is utilized by several cytoplasmic DNA sensor molecules to transduce signals that activate the IRF3 transcription factor?
MAVS
Test your knowledge on the differences between RIG-like receptors and the NLRP3 inflammasome in the innate immune system. Learn about how RLRs primarily detect viral RNA and induce an antiviral response, while the NLRP3 inflammasome responds to various forms of cellular stress or damage, activating inflammatory processes.
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