Innate Immune System
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Questions and Answers

Which of the following is NOT a feature of the innate immune system?

  • Phagocytes
  • Chemical barriers
  • Mechanical barriers
  • Antibody production (correct)

Which cells are involved in the bloodborne defense mechanism of the innate immune system?

  • B cells
  • Plasma cells
  • T cells
  • Macrophages (correct)

Which pathway is NOT involved in the complement cascade of the innate immune system?

  • Lectin pathway
  • Alternative pathway
  • Classical pathway
  • Humoral pathway (correct)

Which type of T cell is responsible for killing virus-infected cells in the acquired immune system?

<p>Cytotoxic T cells (B)</p> Signup and view all the answers

Which of the following is NOT an example of a mucosal surface where the innate immune system plays a crucial role?

<p>Nervous system (B)</p> Signup and view all the answers

Which of the following is NOT a component of the mechanical barriers in the innate immune system?

<p>Neutrophils (D)</p> Signup and view all the answers

Which types of phagocyte are involved in the innate immune response and is known for its ability to engulf and destroy pathogens?

<p>Macrophages (B)</p> Signup and view all the answers

Which pathway of the complement cascade is activated by antibody-antigen complexes?

<p>Classical pathway (B)</p> Signup and view all the answers

Which type of cell is responsible for the production of antibodies in acquired immunity?

<p>Plasma cells (B)</p> Signup and view all the answers

Which of the following is a main function of the innate immune system?

<p>Rapid response to pathogens (D)</p> Signup and view all the answers

Which type of cell is responsible for the production of specific antibodies in the adaptive immune system?

<p>B cells (D)</p> Signup and view all the answers

Which cells migrate to lymph nodes in the innate immune response?

<p>Dendritic cells (C)</p> Signup and view all the answers

Which of the following is a feature of the adaptive immune system?

<p>Specific antibodies (B)</p> Signup and view all the answers

Which type of cell is responsible for producing RegIll in the innate immune system?

<p>Paneth cells (B)</p> Signup and view all the answers

Which epithelial surface contains histatins and beta-defensins?

<p>Oral cavity (D)</p> Signup and view all the answers

Which immune response is responsible for the production of specific antibodies?

<p>Humoral immunity (C)</p> Signup and view all the answers

Which antimicrobial peptides are primarily found in the stratum spinosum of the epidermis?

<p>Beta-defensins (B)</p> Signup and view all the answers

Which type of cells in the bronchial ciliated epithelium are responsible for producing alpha-defensins?

<p>Type 2 pneumocytes (C)</p> Signup and view all the answers

Which of the following is a primary function of cathelicidins in innate immunity?

<p>Disruption of microbial membranes (D)</p> Signup and view all the answers

Which complement pathway is activated by the binding of mannose-binding lectin (MBL) to microbial surfaces?

<p>Lectin pathway (D)</p> Signup and view all the answers

Which complement pathway is activated by the binding of C1q to antibody-antigen complexes?

<p>Classical pathway (B)</p> Signup and view all the answers

Which complement pathway is activated by the spontaneous hydrolysis of C3?

<p>Alternative pathway (A)</p> Signup and view all the answers

Which complex is formed in the alternative pathway of complement activation and acts as a C3 convertase?

<p>C3bBb (A)</p> Signup and view all the answers

What are the three main functions of the complement system?

<p>Opsonization, inflammation, membrane attack (B)</p> Signup and view all the answers

Which molecule(s) are involved in the recognition and binding of carbohydrates on the pathogen surface in the lectin pathway?

<p>MBL and ficolins (B)</p> Signup and view all the answers

What is the function of C3a and C5a in the lectin pathway?

<p>They promote inflammation. (B)</p> Signup and view all the answers

Which complement protein interacts with pathogen surface or with antibodies bound to surface in classical pathway?

<p>C1q (D)</p> Signup and view all the answers

What is the main function of C3 convertase in the complement cascade?

<p>Cleaving C3 and releasing C3a (B)</p> Signup and view all the answers

Which type of cells are responsible for engulfing and destroying the pathogen in the classical pathway?

<p>Phagocytes with receptors for C3b (B)</p> Signup and view all the answers

Which proteins are involved in the activation of the classical pathway?

<p>C1q, C1r, C1s (A)</p> Signup and view all the answers

Which component of the alternative pathway undergoes spontaneous hydrolysis and initiates the deposition of C3 convertase on microbial surfaces?

<p>C3 (B)</p> Signup and view all the answers

In alternative pathway, what is the main function of the membrane-attack complex (MAC) in the complement cascade?

<p>To disrupt cell membrane and cause cell lysis (C)</p> Signup and view all the answers

What is the result of C3 cleavage in all complement pathways?

<p>C3b is released and binds to the microbial surface. (A)</p> Signup and view all the answers

What is the final outcome of the complement cascade in the alternative pathway?

<p>Formation of a membrane-attack complex (MAC) (A)</p> Signup and view all the answers

Which component of the alternative pathway stabilizes the C3 convertase and prevents its degradation?

<p>Properdin (C)</p> Signup and view all the answers

Which complement protein can activate macrophages to phagocytose bacteria via CR1?

<p>C5a (D)</p> Signup and view all the answers

When a bacterium is coated with C3b, which receptor binding is necessary for phagocytosis to occur?

<p>CR1 (A)</p> Signup and view all the answers

Which complement protein does NOT stimulate an increase in blood flow and vascular permeability?

<p>C3b (B)</p> Signup and view all the answers

Which complement protein directly increases the activity of phagocytes?

<p>C5a (A)</p> Signup and view all the answers

Which complement components are involved in mediating inflammation?

<p>C3a, C4a, C5a (B)</p> Signup and view all the answers

What is the outcome of small complement-cleavage products acting on blood vessels to increase vascular permeability?

<p>Increased fluid leakage from blood vessels and extravasation of immunoglobulin and complement molecules. (A)</p> Signup and view all the answers

Which complement proteins bind to form the membrane attack complex (MAC)?

<p>C5b, C6, C7, C8, C9 (C)</p> Signup and view all the answers

What is the function of C9 in the membrane attack complex (MAC)?

<p>Polymerize and bind to form a pore (C)</p> Signup and view all the answers

What is the function of the membrane attack complex (MAC)?

<p>To create a pore in the bacterial cell membrane and kill bacteria. (D)</p> Signup and view all the answers

Which complement component binds to the C5b67 complex and allows its attachment to the cell membrane?

<p>C7 (B)</p> Signup and view all the answers

What is the consequence of the formation of a pore in the bacterial cell membrane by the membrane attack complex (MAC)?

<p>Leakage of cellular contents and bacterial cell death. (D)</p> Signup and view all the answers

Which cells are responsible for phagocytosis in the innate immune response?

<p>Monocytes and dendritic cells (D)</p> Signup and view all the answers

Which enzyme produces superoxide free radicals in phagocytic cells?

<p>NADPH oxidase (B)</p> Signup and view all the answers

What happens to the pathogen after it is internalized in a phagosome during phagocytosis?

<p>It fuses with a lysosome (B)</p> Signup and view all the answers

Which cells are responsible for the production of cytokines that attract and activate other cells in the innate immune response?

<p>Macrophages (A)</p> Signup and view all the answers

What triggers an inflammatory response during an infection?

<p>Pathogen-associated molecular patterns (PAMPs) (B)</p> Signup and view all the answers

Which component of the complement pathway stabilizes the C3 convertase and prevents its degradation?

<p>Factor B (A)</p> Signup and view all the answers

What is the primary function of cathelicidins in innate immunity?

<p>Engulfing and destroying pathogens (B)</p> Signup and view all the answers

Which pathway of the complement cascade is activated by the binding of C1q to antibody-antigen complexes?

<p>Classical pathway (A)</p> Signup and view all the answers

Which of the following is a consequence of increased vascular permeability caused by complement protein-mediated inflammation?

<p>Increased fluid leakage from blood vessels and extravasation of immunoglobulin (B)</p> Signup and view all the answers

What is the result of the migration of macrophages, polymorphonuclear leukocytes (PMNs), and lymphocytes being increased due to complement protein-mediated inflammation?

<p>Increased microbicidal activity of macrophages and PMNs (D)</p> Signup and view all the answers

What is the consequence of the local release of TNF-α during inflammation?

<p>Protective effect (A)</p> Signup and view all the answers

Which complement proteins act on blood vessels to increase vascular permeability and cell-adhesion molecules?

<p>C3a, C4a, C5a (B)</p> Signup and view all the answers

What is the outcome of systemic release of TNF-α during infection?

<p>Systemic shock (A)</p> Signup and view all the answers

Which chemical factor is NOT involved in induced responses of innate immunity?

<p>Nitric oxide (D)</p> Signup and view all the answers

What is the role of resident cells, such as macrophages and dendritic cells, in induced responses of innate immunity?

<p>Recognition of pathogen-associated molecular patterns (PAMPs) (D)</p> Signup and view all the answers

What is the role of effector T cells in inflammation?

<p>Activating macrophages (A)</p> Signup and view all the answers

Which proteins undergo opsonization?

<p>All of the above (D)</p> Signup and view all the answers

Which cells activate macrophages?

<p>Effector T cells (C)</p> Signup and view all the answers

What activates natural killer (NK) cells to serve as an early defense against certain intracellular infections?

<p>Interferon and macrophage-derived cytokines (A)</p> Signup and view all the answers

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