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Questions and Answers
What is the primary method of transmission for scabies?
Which of the following is NOT a symptom of scabies?
What is the preferred first-line treatment for scabies in adults?
Which area of the body is most commonly affected by scabies burrows?
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When diagnosing scabies, which of the following methods is essential?
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What specific precaution should be taken following a diagnosis of scabies in a household?
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Which symptom is pathognomonic for measles?
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What is the gold standard for diagnosing measles?
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What role does Vitamin A supplementation play in measles treatment?
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For how long should a patient with measles be isolated from the onset of rash?
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Which of the following is NOT a common symptom of measles?
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In a patient with measles, which precaution should be initiated if they are hospitalized?
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What is a potential complication of measles that Vitamin A supplementation helps mitigate?
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What is the primary method used for confirming the diagnosis of Tinea Versicolor in the mentioned case?
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Which statement regarding measles vaccination is accurate?
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What characteristic feature of the lesions observed in the 13-year-old boy is indicative of Tinea Versicolor?
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Which treatment option is NOT typically indicated for Tinea Versicolor?
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In the case of the 10-year-old girl, what additional symptom prior to the rash could be a significant indicator of a viral etiology?
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Which of the following findings would support the diagnosis of Pityriasis Rosea rather than Tinea Versicolor?
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During the examination of the 13-year-old boy, if the lesions were described as oval and arranged in a Christmas tree pattern, which diagnosis would be more appropriate?
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What is a significant complication associated with measles in infants and young children?
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Which symptom is typically associated with acute measles infection?
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What is the preferred method for confirming a diagnosis of tinea versicolor?
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What treatment modality is considered first-line for tinea versicolor?
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In the case of the 5-year-old boy diagnosed with measles, what immediate step should be taken?
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Which characteristic skin lesion might be found in a patient with tinea versicolor?
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What underlying health condition does the 21-year-old man have that may impact his dermatological health?
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What symptom is indicative of severe dehydration seen in the 5-year-old boy?
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What type of rash is typically associated with measles?
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What pattern of skin lesions would most likely be seen in a potassium hydroxide preparation for tinea versicolor?
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What triggers the immunological response in scabies?
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Which symptom is least likely to be experienced by a patient with scabies?
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Which area is typically not a predilection site for scabies infestation?
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What is the recommended treatment for scabies in a case where topical permethrin is contraindicated?
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Which statement regarding the diagnosis of scabies is accurate?
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What is the primary preventive measure recommended for scabies spread within a household?
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In which condition is a child with eczema more likely to be at risk for developing scabies?
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What is the duration of the intense itching experienced by a patient diagnosed with scabies?
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What key characteristics must be evaluated in a skin lesion to assess for malignant melanoma?
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For the diagnosis of malignant melanoma, which procedure is considered definitive?
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What is a significant factor influencing the prognosis of malignant melanoma?
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Which physical findings might suggest a diagnosis of squamous cell carcinoma rather than malignant melanoma?
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In assessing a skin lesion for possible malignancy, which feature is least indicative of an immediate concern?
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What is a significant complication associated with measles that could affect the central nervous system?
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Which of the following sign patterns would suggest a diagnosis of tinea versicolor upon examination?
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In the case of the 5-year-old boy with measles, which symptom indicates severe dehydration?
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What is the recommended first-line treatment for tinea versicolor?
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What systemic condition does the 21-year-old man have that may alter his symptoms of a rash?
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Which symptom is commonly associated with the diagnosis of measles in children?
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What should be the immediate next step in the management of a patient diagnosed with measles?
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What immune response complication can occur in patients with tinea versicolor?
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What key indicator about the rashes can help distinguish measles from tinea versicolor?
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Which demographic factor might impact the expression and severity of measles in the 5-year-old boy?
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What is the most likely diagnosis for a firm, non-tender nodular lesion with central ulceration on a patient who has significant sun exposure?
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Which treatment method is most appropriate for basal cell carcinoma located on the face?
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What is a distinguishing feature of squamous cell carcinoma compared to basal cell carcinoma?
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Which biopsy method is primarily used for diagnosing squamous cell carcinoma?
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Which symptom is NOT typically associated with basal cell carcinoma?
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What feature is characteristic of basal cell carcinoma lesions?
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What is a common risk factor for developing squamous cell carcinoma?
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Which characteristic distinguishes melanoma from basal cell carcinoma?
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What is the most common type of skin cancer?
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Which factor contributes most significantly to the risk of developing skin cancers like basal cell carcinoma?
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What type of skin lesions are characteristic of Tinea Versicolor?
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Which of the following is the underlying cause suspected for Pityriasis Rosea?
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What is the first-line treatment for Tinea Versicolor?
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Which laboratory confirmation method is used for diagnosing Tinea Versicolor?
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Which finding would distinguish Tinea Versicolor from Pityriasis Rosea?
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What additional history is significant in the case of the 13-year-old boy with Tinea Versicolor?
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What is a common misconception about the lesions of Pityriasis Rosea?
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In which demographic is Tinea Versicolor most commonly diagnosed?
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What are the general characteristics of the lesions seen in Pityriasis Rosea?
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Which treatment is typically not indicated for Pityriasis Rosea?
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Which of the following is NOT a feature of the ABCDE criteria used for assessing malignant melanoma?
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In a case of a nonhealing ulcer on the left upper extremity, which characteristic of the lesion is most consistent with squamous cell carcinoma?
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What is the definitive method for diagnosing malignant melanoma?
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Which of the following factors is most relevant for determining the prognosis of malignant melanoma?
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What is the most appropriate initial treatment for a diagnosed melanoma based on the Breslow depth?
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What mechanism leads to the intense itching experienced by patients with scabies?
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Which statement about the signs and symptoms associated with scabies is accurate?
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In a case of scabies, what is the most critical diagnostic requirement for confirming the infestation?
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What preventive measure should be taken to minimize scabies transmission within a household?
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Which of the following correctly represents the agents used to treat scabies?
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What is a common misconception regarding the transmission route of scabies?
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Which skin examination finding is atypical for a scabies infection?
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In terms of clinical presentation, which symptom can be expected to worsen during the night in a person with scabies?
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What complication is specifically increased in patients diagnosed with measles?
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What is the primary characteristic of the rash observed in measles?
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Which physical examination finding in the 5-year-old boy suggests dehydration?
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What is the primary sign indicative of tinea versicolor during a potassium hydroxide preparation?
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In the management of the 5-year-old boy with measles, what is the next step recommended?
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What typical symptom may accompany the rash in a patient with tinea versicolor?
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What primary action should be taken when treating tinea versicolor?
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What history detail might suggest an environmental trigger for the rash in the 21-year-old man?
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In a patient presenting with skin lesions and an unknown vaccination history, what is a concerning complication to monitor for regarding measles?
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What is the appropriate first step in the evaluation of suspected tinea versicolor?
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What is the characteristic feature of the rash observed in measles?
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Which symptom is considered pathognomonic for measles?
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What is the recommended duration for isolating a patient diagnosed with measles from the onset of the rash?
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What is the primary method for confirming a diagnosis of measles?
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In measles management, what additional benefit does Vitamin A supplementation provide?
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During a physical exam of a measles patient, which finding would warrant immediate airborne precautions if hospitalized?
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What is the role of live attenuated vaccines in measles prevention?
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Which of the following is a potential complication associated with measles in immunocompromised patients?
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In cases of measles, which symptom would likely precede the rash?
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What is a common sign that may suggest the presence of measles in a child who has not been vaccinated?
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What microscopic finding is typically observed in a potassium hydroxide preparation for Tinea Versicolor?
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Which treatment options are appropriate for managing Tinea Versicolor?
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In the context of Pityriasis Rosea, which feature is most characteristic of the rash?
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Which symptom could suggest a differential diagnosis for the 10-year-old girl's rash?
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What is a significant comparison between Tinea Versicolor and Pityriasis Rosea in terms of diagnosis?
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Which underlying condition in the 13-year-old boy's family could contribute to his skin condition?
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How long do lesions from Pityriasis Rosea typically persist before resolution?
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What is an expected finding when scraping the lesions of Tinea Versicolor?
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What might indicate a potential viral cause in a child presenting with rash, especially when associated with prior systemic symptoms?
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Study Notes
Scabies
- Highly contagious skin infection caused by the mite Sarcoptes scabiei.
- Transmitted through direct skin-to-skin contact.
- Mites burrow into the skin causing intense itching, especially at night.
- Common sites: Interdigital folds, genitalia.
- Diagnostic confirmation: Visualization of mites, eggs, or feces using a dermatoscope.
- Treatment: Topical permethrin 5% lotion or oral ivermectin.
- Prevention: Thorough washing of textiles and treatment of all household contacts.
Measles
- Viral infection caused by the Paramyxovirus.
- Characterized by: fever, cough, runny nose, conjunctivitis, Koplik spots (small white spots on the inner lining of the cheek), and a red, flat rash that spreads from the face to the rest of the body.
- Diagnostic confirmation: Detection of Measles-specific IgM antibodies or PCR.
- Treatment: Symptomatic management and vitamin A supplementation.
- Prevention: Live attenuated vaccine.
- Isolation: Isolate patients for 4 days from onset of rash. Airborne precautions in hospitalized patients.
Tinea Versicolor
- Fungal infection caused by Malassezia furfur.
- Characterized by: hypopigmented, hyperpigmented, or erythematous skin lesions that typically occur on the trunk and chest.
- Diagnostic confirmation: Observing "spaghetti-and-meatballs" pattern in potassium hydroxide (KOH) preparation.
- Treatment: Topical antifungals (Selenium sulfide or zinc pyrithione) or oral antifungals (fluconazole).
Pityriasis Rosea
- Idiopathic rash, suspected viral etiology (HHV 6 and 7).
- Characterized by: Prodromal flu-like symptoms followed by multiple, oval, scaly papules, resembling a "Christmas tree" pattern on the trunk.
- Diagnostic confirmation: Clinical diagnosis. KOH preparation for exclusion of tinea and RPR/VDRL for exclusion of secondary syphilis.
- Treatment: Spontaneous resolution within 6-8 weeks.
Skin Cancer
- Most important skin cancers: Basal cell carcinoma (BCC), Squamous cell carcinoma (SCC), Melanoma.
- Most common type: Basal cell carcinoma.
Basal Cell Carcinoma (BCC)
- Characterized by: Painless, pearly, firm, telangiectatic papules.
- Most common location: Face or other sun-exposed areas.
- Diagnostic confirmation: Excisional biopsy, shave biopsy, or punch biopsy.
- Treatment: Surgical excision with margins (3-5 mm for trunk and extremities, Mohs micrographic surgery for face).
Squamous Cell Carcinoma (SCC)
- Characterized by: Nodular lesion with intermittent bleeding and itching.
- Lesions often become keratinized and can ulcerate with crusting and bleeding.
- Perineural invasion, numbness, paresthesia, and itching can occur.
- Diagnostic confirmation: Shave biopsy.
- Treatment: Surgical excision or Mohs surgery. Radiation or chemotherapy may be needed for high metastatic potential.
Scabies
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Pathogen: Sarcoptes scabiei
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Transmission: Direct physical (skin-to-skin or sexual) contact
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Pathophysiology: The mite's excretions and decomposing bodies cause an immune response
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Symptoms: Pimple-like rash, burrows, intense itching that worsens at night
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Predilection Sites: Interdigital folds, male genitalia
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Diagnosis: Visualization of mites, eggs, or feces using a dermatoscope
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Treatment: Topical permethrin 5% lotion, oral ivermectin
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Prevention: Wash all textiles, treat all household members even if asymptomatic.
Case 1: 4-Year-Old Boy
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Symptoms: Pruritic rash on hands and feet for 2 weeks, worse at night
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Diagnosis: Scabies
Case 2: 26-Year-Old Man
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Symptoms: Pruritic rash with small red bumps in linear pattern, worse at night
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Diagnosis: Scabies
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Confirmation: Visualization of mites, eggs, or feces using a dermatoscope
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Treatment: Topical permethrin
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Prevention: Treat all close contacts.
Measles
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Pathogen: Paramyxovirus, an RNA Virus
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Complications: Encephalitis
Case 5: 5-Year-Old Boy
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Symptoms: Progressive rash starting on the face and spreading to the trunk and extremities, runny nose, cough, red crusty eyes
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Diagnosis: Measles
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Next Steps: Obtain a viral culture
Tinea Versicolor
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Pathogen: Malassezia furfur
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Pathophysiology: Malassezia furfur damages melanocytes leading to hypopigmentation. An inflammatory response may result in hyperpigmentation.
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Symptoms: Hypopigmented, hyperpigmented, or erythematous skin lesions, commonly on the trunk and chest.
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Diagnosis: Clinical, KOH preparation shows "spaghetti-and-meatballs" pattern
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Treatment: First-line: topical antifungals (selenium sulfide or zinc pyrithione). Second-line: oral antifungals (fluconazole).
Case 6: 21-Year-Old Man
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Symptoms: Pruritic hypopigmented rash on upper body, started after a trip to the Bahamas
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Diagnosis: Tinea Versicolor
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Confirmation: KOH preparation showing hyphae and yeast cells
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Treatment: Topical or oral antifungals
Case 7: 13-Year-Old Boy
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Symptoms: Rash on chest and back starting as a few lesions and spreading.
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Diagnosis: Tinea Versicolor
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Confirmation: KOH preparation
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Treatment: Topical or oral antifungals
Pityriasis Rosea
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Etiology: Idiopathic, suspected viral etiology (HHV 6 and 7)
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Symptoms: Prodromal flu-like illness, multiple scaly oval papules in a "Christmas tree" pattern on the trunk, itching. Lesions usually resolve within 2 months.
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Diagnosis: Usually clinical, laboratory tests only if uncertain
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Confirmation: KOH preparation to rule out tinea, RPR or VDRL to rule out syphilis
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Treatment: Spontaneous resolution in 6-8 weeks
Case 8: 10-Year-Old Girl
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Symptoms: Pruritic rash spreading from single lesion on upper abdomen to trunk, neck, and arms. Previous fever, sore throat, malaise.
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Diagnosis: Pityriasis Rosea
Skin Cancer
- Important skin cancers: BCC, SCC, melanoma
- Most common type: Basal cell carcinoma
Common Key Words
- Painless lesion
- History of sun exposure (Australia, summer, outdoor job)
- Increase in size over months
Basal Cell Carcinoma
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Symptoms: Nodular lesion with central ulceration, non-tender, firm, pearly telangiectatic papules, most appear on sun-exposed areas.
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Diagnosis: Excisional, shave or punch biopsy
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Treatment: Surgical excision with 3-5 mm margins for trunk and extremities. Mohs surgery for lesions on the face.
Case 9: 48-Year-Old Woman
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Symptoms: Small swelling on neck slowly enlarging, has worked outdoors her entire life.
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Diagnosis: Basal Cell Carcinoma
Squamous Cell Carcinoma
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Symptoms: Common in patients with history of transplants, immunosuppressive therapy, ionizing radiation, burn injuries. Nodular lesion with intermittent bleeding and itching. Lesions can become keratinized, ulcerate with crusting and bleeding. Perineural invasion results in numbness, paresthesia, and itching.
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Diagnosis: Shave biopsy demonstrating keratin pearls, atypical keratinocytes invading the dermis.
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Treatment: Surgical excision or Mohs surgery. Radiation or chemotherapy for lesions with high metastatic potential.
Case 10: 65-Year-Old Man
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Symptoms: Non-healing ulcer on left upper extremity, enlarging, ulcerated, bleeding and itching.
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Diagnosis: Squamous Cell Carcinoma
Malignant Melanoma
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Symptoms: ABCDE criteria: asymmetry, border, color, diameter > 6 mm, evolving. "Ugly duckling" sign - lesion significantly different from others.
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Diagnosis: Skin biopsy
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Treatment: Wide local excision with margins based on Breslow depth
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Prognosis: Tumor thickness (Breslow depth)
Case 11: 63-Year-Old Man
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Symptoms: Skin lesion on chest, increasing in size, painless and not pruritic.
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Diagnosis: Malignant Melanoma
Scabies
- Pathogen: Sarcoptes scabiei
- Transmission: Direct contact with an infected person.
- Pathophysiology: The mite's excretions and decomposing bodies trigger an immune response.
-
Signs and Symptoms:
- Pimple-like rash
- Burrow tracks in the skin
- Intense itching, especially at night
- Predilection Sites: Interdigital folds, male genitalia.
- Diagnosis: Visualize the mites, eggs, or feces using a dermatoscope.
-
Treatment:
- Topical: Permethrin 5% lotion.
- Oral: Ivermectin.
-
Prevention:
- Wash all textiles (clothing, bedding).
- Treat all household members, even if asymptomatic.
Measles
- Pathogen: Paramyxovirus, an RNA virus.
-
Signs and Symptoms:
- Fever
- Cough
- Runny nose
- Conjunctivitis
- Koplik spots (small white spots on the inside of the mouth, considered pathognomonic for measles)
- Erythematous maculopapular rash (starts behind ears and spreads down to the feet, rarely affects the hands and soles)
-
Diagnosis:
- Gold standard: Detecting measles-specific IgM antibodies or PCR.
- Treatment: Supportive care with Vitamin A supplementation to reduce mortality.
- Prevention: Live attenuated vaccine.
- Isolation: Isolate patients for at least 4 days from rash onset (longer for immunocompromised individuals). Use airborne precautions for hospitalized patients.
Tinea Versicolor
- Pathogen: Malassezia furfur
- Pathophysiology: M. furfur damages melanocytes, leading to hypopigmentation. The immune response to the pathogen may cause hyperpigmentation.
-
Signs and Symptoms:
- Hypopigmented, hyperpigmented, or erythematous skin lesions.
- Common sites: trunk and chest.
- Diagnosis: Clinical diagnosis is often sufficient.
- Confirmation: Potassium hydroxide (KOH) preparation reveals a "spaghetti-and-meatballs" pattern.
-
Treatment:
- First-line: Topical antifungals (selenium sulfide or zinc pyrithione).
- Severe or unresponsive cases: Oral antifungals (fluconazole).
Pityriasis Rosea
- Etiology: Idiopathic but a viral etiology (HHV 6 and 7) is suspected.
-
Signs and Symptoms:
- Preceded by flu-like symptoms.
- Multiple oval, scaly papules in a "Christmas tree" pattern on the trunk.
- Itching is common.
- Lesions typically resolve within 2 months, sometimes causing postinflammatory hyperpigmentation or hypopigmentation.
- Diagnosis: Usually clinical.
-
Confirmation:
- KOH preparation to rule out tinea.
- RPR or VDRL to rule out secondary syphilis.
- Treatment: Typically self-resolves within 6-8 weeks.
Malignant Melanoma
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Signs and Symptoms:
-
ABCDE criteria:
- Asymmetry: Two halves of the lesion don't match.
- Border: Irregular border with indistinct margins.
- Color: Varied pigmentation within the lesion.
- Diameter: Greater than 6 mm.
- Evolving: Changes in size, shape, or color over time.
- "Ugly Duckling" sign: A lesion that looks different from other moles on the patient's body.
-
ABCDE criteria:
- Diagnosis: Skin biopsy.
- Treatment: Wide local excision with surgical margins determined by the Breslow thickness.
- Prognosis: Tumor thickness, measured by Breslow depth, is a significant prognostic factor.
Case Scenarios
-
Case 1: 4-Year-Old Boy
- Diagnosis: Scabies
- Symptoms: Pruritic rash on hands and feet.
- History: Mother has eczema.
- Physical Exam: Maculopapular rash with linear tracks affecting fingers and toes.
-
Case 2: 26-Year-Old Man
- Diagnosis: Scabies
- Symptoms: Pruritic rash on arm and back.
- History: Recently moved into a new apartment with roommates who also developed similar rashes.
- Physical Exam: Rash with a linear pattern on the arm and clusters of lesions on the back.
-
Case 3: 6-Year-Old Boy
- Diagnosis: Measles
- Symptoms: Progressive rash starting on face and spreading to the entire body. Cough and runny nose.
- History: Recently visited the Philippines. Immunization records unavailable.
- Physical Exam: Fever, generalized lymphadenopathy, erythematous maculopapular rash.
-
Case 4: 11-Year-Old Boy
- Diagnosis: Measles
- Symptoms: Fever, cough, runny nose, and itchy eyes.
- History: Emigrated from Syria recently. No routine childhood vaccinations.
- Physical Exam: Fever, conjunctivitis, Koplik spots.
- Complications: Risk of encephalitis.
-
Case 5: 5-Year-Old Boy
- Diagnosis: Measles
- Symptoms: Progressive rash, runny nose, cough, and red eyes.
- History: Immigrated from Turkey 3 months ago. Father and brother have Behçet disease.
- Physical Exam: Fever, generalized lymphadenopathy, dry mucous membranes, erythematous maculopapular rash, aphthous ulcers.
- Next steps: Obtain viral culture.
-
Case 6: 21-Year-Old Man
- Diagnosis: Tinea Versicolor.
- Symptoms: Hypopigmented rash on upper body.
- History: Recently traveled to the Bahamas.
- Physical Exam: Hypopigmented rash.
- Confirmation: KOH preparation showed hyphae and yeast cells.
-
Case 7: 13-Year-Old Boy
- Diagnosis: Tinea Versicolor.
- Symptoms: Rash on chest and back.
- History: Recently returned from the Caribbean.
- Physical Exam: Multiple, nontender, white macules on chest and trunk.
- Confirmation: KOH preparation.
-
Case 8: 10-Year-Old Girl
- Diagnosis: Pityriasis Rosea.
- Symptoms: Pruritic rash that started as one lesion and spread to the trunk, neck, and arms.
- History: Had fever, sore throat, and malaise before the onset of the rash.
-
Case 10: 65-Year-Old Man
- Diagnosis: Squamous Cell Carcinoma
- Symptoms: Nonhealing ulcer on the left upper extremity.
- History: No history of trauma.
- Physical Exam: Ulcerated lesion.
-
Case 11: 63-Year-Old Man
- Diagnosis: Malignant Melanoma.
- Symptoms: Skin lesion on the chest.
- History: Lesion thought to have increased in size.
- Physical Exam: Skin lesion.
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