Immunology: Antibodies and Functions
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Questions and Answers

What is the primary function of the secretory component (SC) in the context of IgA antibodies?

  • To transport IgA across the placenta
  • To mediate binding of antibodies to mucin in the mucus layer (correct)
  • To enhance opsonization of pathogens by IgA
  • To facilitate binding of IgA to Fc receptors
  • Which of the following accurately describes how maternal IgG is transferred to a fetus?

  • It enters circulation through lymphatic vessels
  • It is actively secreted through breast milk
  • It is synthesized by the fetus during pregnancy
  • It is transported across the placenta by the neonatal Fc receptor (FcRn) (correct)
  • How do antibodies contribute to neutralization of toxins?

  • By promoting phagocytosis via opsonization
  • By binding to receptor-binding sites of toxins to prevent cell entry (correct)
  • By enhancing the immune response through complement activation
  • By inducing apoptosis in infected cells
  • What role does FcRn play in adults?

    <p>It maintains plasma levels of IgG and prevents its excretion</p> Signup and view all the answers

    What is the mechanism of antibody-mediated opsonization?

    <p>Antibodies bind to extracellular pathogens marking them for phagocytosis</p> Signup and view all the answers

    Which type of antibody is predominantly secreted in breast milk to protect newborns?

    <p>IgA</p> Signup and view all the answers

    In what form does IgA predominantly exist when secreted from plasma cells?

    <p>Dimeric form</p> Signup and view all the answers

    What happens to IgG antibodies that are ingested from maternal milk?

    <p>They are absorbed and transported into the bloodstream by FcRn</p> Signup and view all the answers

    What is the primary function of virus-neutralizing antibodies?

    <p>To block binding of viruses to surface receptors</p> Signup and view all the answers

    How do high-affinity IgG and IgA antibodies contribute to neutralization of toxins?

    <p>By neutralizing toxins and blocking infectivity</p> Signup and view all the answers

    What is the role of Fc receptors on phagocytes?

    <p>They enhance the recognition and ingestion of pathogens</p> Signup and view all the answers

    What consequences can arise from the failure to remove immune complexes from circulation?

    <p>They can cause tissue damage in small blood vessels</p> Signup and view all the answers

    Which type of receptor is most closely associated with triggering exocytosis in mast cells during allergic reactions?

    <p>FcεRI</p> Signup and view all the answers

    What mechanism primarily allows natural killer (NK) cells to kill antibody-coated target cells?

    <p>Antibody-dependent cell-mediated cytotoxicity (ADCC)</p> Signup and view all the answers

    Which immunoglobulin is primarily involved in the allergic response by binding to mast cells?

    <p>IgE</p> Signup and view all the answers

    What is the primary role of IgA antibodies in mucosal surfaces?

    <p>Inhibit colonization by pathogens</p> Signup and view all the answers

    What type of antigens does the FcγR receptor family specifically recognize?

    <p>IgG antibodies</p> Signup and view all the answers

    Which type of complement activation pathway is triggered by antibody:antigen complexes?

    <p>Classical pathway</p> Signup and view all the answers

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