5 Questions
What is the main mechanism for transporting maternal antibodies to fetus/newborns?
Neonatal Fc receptor (FcRn) in placenta
What is the key regulator for isotype switching to IgA?
TGF-b
What percentage of daily Ig production is IgA in the intestines?
60-70%
What is the role of TGFβ in tumorigenesis?
Inhibits cell cycle promotion
How do microbes evade detection by antibodies?
Undergo mutations
Test your knowledge of mucosal immunity and the production of IgA antibodies, including their transport across mucosal epithelial layers and the role of TGF-b in isotype switching. Learn about the poly-Ig receptor and the high levels of IgA production in the intestines.
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