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Questions and Answers
What is the first signal required for T cell activation during antigen recognition?
What is the first signal required for T cell activation during antigen recognition?
- Interaction of CD 28 with CD 80 or CD 86
- Engagement of TCR by MHC-antigen complex (correct)
- Release of cytokines from B cells
- Binding of antibodies to TCR
Which coreceptors are involved in T cell recognition during antigen activation?
Which coreceptors are involved in T cell recognition during antigen activation?
- CD 4 and CD 28
- CD 28 and CD 80
- CD 4 and CD 8 (correct)
- CD 16 and CD 14
What happens to T cells in the absence of the second activation signal?
What happens to T cells in the absence of the second activation signal?
- They release cytokines
- They proliferate and mount an immune response
- They differentiate into memory cells
- They undergo apoptosis or become anergic (correct)
Which molecules interact with CD 28 during T cell activation?
Which molecules interact with CD 28 during T cell activation?
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What is the role of CD receptors during T cell activation?
What is the role of CD receptors during T cell activation?
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Study Notes
T Cell Activation
- T cells require two signals for complete activation.
- Signal 1 involves the T cell receptor (TCR) recognizing a specific antigen presented by an MHC molecule on an antigen-presenting cell (APC).
- CD4 or CD8 coreceptors also play a role in signal 1, enhancing TCR binding.
- Signal 2 is mediated by the interaction between CD28 on the T cell and CD80 or CD86 on the APC.
- Absence of signal 2 leads to T cell apoptosis or anergy, preventing autoimmunity.
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