T Cell Activation Mechanisms

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Questions and Answers

What is the first signal required for T cell activation during antigen recognition?

  • Interaction of CD 28 with CD 80 or CD 86
  • Engagement of TCR by MHC-antigen complex (correct)
  • Release of cytokines from B cells
  • Binding of antibodies to TCR

Which coreceptors are involved in T cell recognition during antigen activation?

  • CD 4 and CD 28
  • CD 28 and CD 80
  • CD 4 and CD 8 (correct)
  • CD 16 and CD 14

What happens to T cells in the absence of the second activation signal?

  • They release cytokines
  • They proliferate and mount an immune response
  • They differentiate into memory cells
  • They undergo apoptosis or become anergic (correct)

Which molecules interact with CD 28 during T cell activation?

<p>CD 80 and CD 86 (D)</p> Signup and view all the answers

What is the role of CD receptors during T cell activation?

<p>Facilitating the recognition of antigens by TCR (A)</p> Signup and view all the answers

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Study Notes

T Cell Activation

  • T cells require two signals for complete activation.
  • Signal 1 involves the T cell receptor (TCR) recognizing a specific antigen presented by an MHC molecule on an antigen-presenting cell (APC).
  • CD4 or CD8 coreceptors also play a role in signal 1, enhancing TCR binding.
  • Signal 2 is mediated by the interaction between CD28 on the T cell and CD80 or CD86 on the APC.
  • Absence of signal 2 leads to T cell apoptosis or anergy, preventing autoimmunity.

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