Podcast
Questions and Answers
What is the first signal required for T cell activation during antigen recognition?
What is the first signal required for T cell activation during antigen recognition?
Which coreceptors are involved in T cell recognition during antigen activation?
Which coreceptors are involved in T cell recognition during antigen activation?
What happens to T cells in the absence of the second activation signal?
What happens to T cells in the absence of the second activation signal?
Which molecules interact with CD 28 during T cell activation?
Which molecules interact with CD 28 during T cell activation?
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What is the role of CD receptors during T cell activation?
What is the role of CD receptors during T cell activation?
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Study Notes
T Cell Activation
- T cells require two signals for complete activation.
- Signal 1 involves the T cell receptor (TCR) recognizing a specific antigen presented by an MHC molecule on an antigen-presenting cell (APC).
- CD4 or CD8 coreceptors also play a role in signal 1, enhancing TCR binding.
- Signal 2 is mediated by the interaction between CD28 on the T cell and CD80 or CD86 on the APC.
- Absence of signal 2 leads to T cell apoptosis or anergy, preventing autoimmunity.
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Description
This quiz focuses on the critical signals involved in T cell activation. You'll explore the roles of T cell receptors, coreceptors, and the importance of intercellular interactions in immune responses. Test your knowledge on how these signals prevent autoimmunity and promote effective immune function.
