23 Questions
Which is not a goal of therapy for Immune-Mediated Polyarthritis (IMPA)?
Promotion of muscle mass reduction
What is the hallmark of Immune-Mediated Polyarthritis (IMPA) in synovial fluid analysis?
Lymphocytic synovial fluid
Which medication is commonly used for Immune-Mediated Polyarthritis (IMPA) treatment, but can lead to muscle mass reduction and increased ligament laxity in large/giant breed dogs?
Prednisone
Which agents have shown promise in achieving remission in Immune-Mediated Polyarthritis (IMPA) cases as adjunctive therapy?
Leflunomide and cyclosporine
What is an appropriate choice as a second agent to prednisone therapy in Immune-Mediated Polyarthritis (IMPA) cases?
Azathioprine
What is a reliable marker for monitoring IMPA, as it correlates with joint fluid cellularity and joint mobility, and decreases with treatment efficacy?
Plasma C-Reactive Protein
What is important for managing IMPA during the initial treatment phase?
Limiting activity
What type of synovial fluid is not a hallmark of Immune-Mediated Polyarthritis (IMPA)?
Hyaluronic acid-rich synovial fluid
Which medication can be used for anti-inflammatory and analgesic support in Immune-Mediated Polyarthritis (IMPA) cases where steroids are not suitable?
Gabapentin
What involves gross and cytologic analysis including color, turbidity, viscosity, protein, cell count, and cytology?
Synovial fluid analysis
What is a potential consequence of high steroid doses in large/giant breed dogs during Immune-Mediated Polyarthritis (IMPA) treatment?
Reduced muscle mass
Which type of Immune-Mediated Polyarthritis (IMPA) is the most common?
Type 1 - Idiopathic
What is the hallmark of Immune-Mediated Polyarthritis (IMPA) in synovial fluid analysis?
Antigen-antibody complex deposition
What is a potential consequence of high steroid doses in large/giant breed dogs during Immune-Mediated Polyarthritis (IMPA) treatment?
Muscle mass reduction
What involves gross and cytologic analysis including color, turbidity, viscosity, protein, cell count, and cytology?
Joint taps
Which medication is commonly used for Immune-Mediated Polyarthritis (IMPA) treatment, but can lead to muscle mass reduction and increased ligament laxity in large/giant breed dogs?
Prednisone
Which is not a cause of Immune-Mediated Polyarthritis (IMPA)?
Severe immune-complex deposition
What is a reliable marker for monitoring IMPA, as it correlates with joint fluid cellularity and joint mobility, and decreases with treatment efficacy?
Inflammatory synovial fluid
What is important for managing IMPA during the initial treatment phase?
Rule out secondary causes
Which medication can be used for anti-inflammatory and analgesic support in Immune-Mediated Polyarthritis (IMPA) cases where steroids are not suitable?
Firocoxib
Which agents have shown promise in achieving remission in Immune-Mediated Polyarthritis (IMPA) cases as adjunctive therapy?
Immunosuppressants
What type of synovial fluid is not a hallmark of Immune-Mediated Polyarthritis (IMPA)?
Non-inflammatory
What is a potential consequence of high steroid doses in large/giant breed dogs during Immune-Mediated Polyarthritis (IMPA) treatment?
Muscle mass reduction
Study Notes
Immune-Mediated Polyarthritis in Dogs: Diagnosis and Treatment
- Differential diagnosis for joint taps includes ruling out secondary causes such as infectious bacterial, fungal, and neoplastic conditions
- Synovial fluid analysis involves gross and cytologic analysis including color, turbidity, viscosity, protein, cell count, and cytology
- Non-septic, suppurative, or lymphocytic synovial fluid is the hallmark of Immune-Mediated Polyarthritis (IMPA)
- Goals of therapy for IMPA involve resolution of inflammation, pain control, and supportive care
- Steroids are commonly used for IMPA treatment, but high doses in large/giant breed dogs can lead to muscle mass reduction and increased ligament laxity
- Adjunctive agents such as leflunomide and cyclosporine have shown promise in achieving remission in IMPA cases
- NSAIDs, tramadol, and gabapentin can be used for anti-inflammatory and analgesic support in cases where steroids are not suitable
- Cyclosporine, mycophenolate, azathioprine, and leflunomide are appropriate choices as second agents to prednisone therapy
- Neuropathic pain medications and NMDA antagonists can be used for pain management in IMPA cases
- Hydration support and limiting activity during the initial treatment phase are important for managing IMPA
- Monitoring IMPA involves repeat joint taps, considering plasma C-Reactive Protein, and assessing clinical signs for remission
- Plasma C-Reactive Protein is a reliable marker for monitoring IMPA, as it correlates with joint fluid cellularity and joint mobility, and decreases with treatment efficacy
Test your knowledge on the diagnosis and treatment of Immune-Mediated Polyarthritis (IMPA) in dogs with this informative quiz. Explore differential diagnosis, synovial fluid analysis, therapy goals, treatment options, monitoring, and more.
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