Podcast
Questions and Answers
What is the primary function of Cytochrome P450 in the human hepatic enzyme system?
What is the primary function of Cytochrome P450 in the human hepatic enzyme system?
- Catalyzing the reduction of NADPH to FAD
- Facilitating electron transport between heme proteins
- Acting as a transcription factor in gene expression
- Metabolizing a variety of molecules through oxidative reactions (correct)
What is another name for Cytochrome P450 based on its function?
What is another name for Cytochrome P450 based on its function?
- Mixed function oxidase (correct)
- Ligase
- Isomerase
- Dehydrogenase
Which structure facilitates the transfer of electrons from NADPH-P450 reductase to Cytochrome P450?
Which structure facilitates the transfer of electrons from NADPH-P450 reductase to Cytochrome P450?
- Phosphatidylcholine (correct)
- Flavin dinucleotide (FAD)
- Flavin mononucleotide (FMN)
- Iron protoporphyrin (heme)
How are the P450s named according to the classification mentioned in the text?
How are the P450s named according to the classification mentioned in the text?
Which P450 isoform exhibits high affinity for specific apoprotein interactions with lipophilic amines?
Which P450 isoform exhibits high affinity for specific apoprotein interactions with lipophilic amines?
What type of molecules does CYP2D6 primarily metabolize?
What type of molecules does CYP2D6 primarily metabolize?
What is the primary function of the iron protoporphyrin in the Cytochrome P450 enzyme system?
What is the primary function of the iron protoporphyrin in the Cytochrome P450 enzyme system?
What is the significance of the heme prosthetic group in Cytochrome P450 enzymes?
What is the significance of the heme prosthetic group in Cytochrome P450 enzymes?
Which isoform of Cytochrome P450 exhibits a high affinity for lipophilic substrates with molecular weights of 200-1200 daltons?
Which isoform of Cytochrome P450 exhibits a high affinity for lipophilic substrates with molecular weights of 200-1200 daltons?
What is the role of the NADPH-P450 reductase in the Cytochrome P450 enzyme system?
What is the role of the NADPH-P450 reductase in the Cytochrome P450 enzyme system?
Which component of the Cytochrome P450 system has a primary absorption max at 450 nm when complexed with carbon monoxide?
Which component of the Cytochrome P450 system has a primary absorption max at 450 nm when complexed with carbon monoxide?
In the Cytochrome P450 system, what is the function of phosphatidylcholine?
In the Cytochrome P450 system, what is the function of phosphatidylcholine?
Which P450 isoform is known for metabolizing only aromatic planar compounds?
Which P450 isoform is known for metabolizing only aromatic planar compounds?
What is the primary classification naming convention for P450 genes?
What is the primary classification naming convention for P450 genes?
What is another name for Cytochrome P450 due to its oxygenase function?
What is another name for Cytochrome P450 due to its oxygenase function?
Which component in the Cytochrome P450 system is tightly bound and essential for biological function?
Which component in the Cytochrome P450 system is tightly bound and essential for biological function?
