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Human Hepatic Cytochrome P450 Enzyme System Quiz

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Human Hepatic Cytochrome P450 Enzyme System Quiz

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Questions and Answers

What is the primary function of Cytochrome P450 in the human hepatic enzyme system?

Catalyzing the reduction of NADPH to FAD

Facilitating electron transport between heme proteins

Acting as a transcription factor in gene expression

Metabolizing a variety of molecules through oxidative reactions (correct)

What is another name for Cytochrome P450 based on its function?

Mixed function oxidase (correct)

Ligase

Isomerase

Dehydrogenase

Which structure facilitates the transfer of electrons from NADPH-P450 reductase to Cytochrome P450?

Phosphatidylcholine (correct)

Flavin dinucleotide (FAD)

Flavin mononucleotide (FMN)

Iron protoporphyrin (heme)

How are the P450s named according to the classification mentioned in the text?

Root symbol CYP followed by an Arabic numeral designating the family Signup and view all the answers

Which P450 isoform exhibits high affinity for specific apoprotein interactions with lipophilic amines?

CYP2D6 Signup and view all the answers

What type of molecules does CYP2D6 primarily metabolize?

Lipophilic substrates with molecular weights of 200-1200 daltons Signup and view all the answers

What is the primary function of the iron protoporphyrin in the Cytochrome P450 enzyme system?

Facilitating electron transport Signup and view all the answers

What is the significance of the heme prosthetic group in Cytochrome P450 enzymes?

Facilitates electron transfer from NADPH-P450 reductase Signup and view all the answers

Which isoform of Cytochrome P450 exhibits a high affinity for lipophilic substrates with molecular weights of 200-1200 daltons?

CYP3A4 Signup and view all the answers

What is the role of the NADPH-P450 reductase in the Cytochrome P450 enzyme system?

Facilitation of electron transfer to P450 Signup and view all the answers

Which component of the Cytochrome P450 system has a primary absorption max at 450 nm when complexed with carbon monoxide?

Iron protoporphyrin Signup and view all the answers

In the Cytochrome P450 system, what is the function of phosphatidylcholine?

Facilitating electron transport Signup and view all the answers

Which P450 isoform is known for metabolizing only aromatic planar compounds?

CYP1A1 Signup and view all the answers

What is the primary classification naming convention for P450 genes?

Root symbol followed by a letter denoting the gene subfamily and an Arabic numeral representing the individual gene Signup and view all the answers

What is another name for Cytochrome P450 due to its oxygenase function?

Microsomal hydroxylase Signup and view all the answers

Which component in the Cytochrome P450 system is tightly bound and essential for biological function?

Iron protoporphyrin (heme) Signup and view all the answers