16 Questions
What is the primary function of Cytochrome P450 in the human hepatic enzyme system?
Metabolizing a variety of molecules through oxidative reactions
What is another name for Cytochrome P450 based on its function?
Mixed function oxidase
Which structure facilitates the transfer of electrons from NADPH-P450 reductase to Cytochrome P450?
Phosphatidylcholine
How are the P450s named according to the classification mentioned in the text?
Root symbol CYP followed by an Arabic numeral designating the family
Which P450 isoform exhibits high affinity for specific apoprotein interactions with lipophilic amines?
CYP2D6
What type of molecules does CYP2D6 primarily metabolize?
Lipophilic substrates with molecular weights of 200-1200 daltons
What is the primary function of the iron protoporphyrin in the Cytochrome P450 enzyme system?
Facilitating electron transport
What is the significance of the heme prosthetic group in Cytochrome P450 enzymes?
Facilitates electron transfer from NADPH-P450 reductase
Which isoform of Cytochrome P450 exhibits a high affinity for lipophilic substrates with molecular weights of 200-1200 daltons?
CYP3A4
What is the role of the NADPH-P450 reductase in the Cytochrome P450 enzyme system?
Facilitation of electron transfer to P450
Which component of the Cytochrome P450 system has a primary absorption max at 450 nm when complexed with carbon monoxide?
Iron protoporphyrin
In the Cytochrome P450 system, what is the function of phosphatidylcholine?
Facilitating electron transport
Which P450 isoform is known for metabolizing only aromatic planar compounds?
CYP1A1
What is the primary classification naming convention for P450 genes?
Root symbol followed by a letter denoting the gene subfamily and an Arabic numeral representing the individual gene
What is another name for Cytochrome P450 due to its oxygenase function?
Microsomal hydroxylase
Which component in the Cytochrome P450 system is tightly bound and essential for biological function?
Iron protoporphyrin (heme)
Test your knowledge on the biotransformation pathway (Phase 1) in the human hepatic cytochrome P450 enzyme system. Learn about the role of P450 in oxidative metabolism, its function as a multicomponent electron transport system, and its presence in the smooth ER of the liver and other tissues.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
