Recent Lessons

Show all results for ""

Feature Overview

Ace your exams with our all-in-one platform for creating and sharing quizzes and tests.

Quizzes

Create quizzes and tests automatically from your content using AI.

Flashcards

Automatically turn your notes into digital flashcards.

Share, Export & Embed

Share with classmates or export to Excel and your learning management system.

Stats & Reporting

Auto-grading quizzes and tests with detailed stats and reports.

Mobile Apps

The smarter way to study – wherever you are.

Pricing

Search...

18 Questions

0 Views

Cytochrome P450 Enzyme System

Choose a study mode

Play Quiz

Study Flashcards

Spaced Repetition

Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Where are Cytochrome P450 enzymes primarily localized?

Lysosomes

Rough endoplasmic reticulum

Golgi apparatus

Smooth endoplasmic reticulum (correct)

What percentage of all drugs commonly introduced to the human body are metabolized by Cytochrome P450 enzymes?

90%

75% (correct)

50%

60%

What is the effect referred to when several agents stimulate drug metabolizing agents in liver microsomes?

Antagonism

Inhibition

Induction (correct)

Synergism

What is the term for when the effect of one drug is diminished or completely abolished in the presence of another?

Antagonism Signup and view all the answers

Which of the following CYP450 enzymes is NOT involved in drug metabolism?

CYP2C20 Signup and view all the answers

What is the effect of Phenobarbitone on the metabolism of bishydroxycoumarin?

Increases the metabolism Signup and view all the answers

What is the primary function of the rough endoplasmic reticulum (ER) in drug metabolism?

Protein synthesis Signup and view all the answers

What type of enzymes are found in microsomes and catalyze Phase I reactions?

Mixed function oxidases/monooxygenases Signup and view all the answers

What is the result of Phase I reactions in drug metabolism?

The drug becomes more water-soluble Signup and view all the answers

What is the result of Phase II reactions in drug metabolism?

The drug becomes more water-soluble and is readily excreted in urine Signup and view all the answers

What is the main organ responsible for drug metabolism?

Liver Signup and view all the answers

What is the name of the enzyme system that is the most important of the monooxygenases?

Cytochrome P450 Signup and view all the answers

What is the primary location where drugs are metabolized?

Liver Signup and view all the answers

What is the result of enzyme induction in drug metabolism?

Enhanced metabolizing enzyme activity Signup and view all the answers

What is the consequence of drug metabolism occurring too slowly?

Toxic side effects Signup and view all the answers

What is the effect of liver disease on drug metabolism?

Complex effects on drug clearance and biotransformation Signup and view all the answers

What is the role of Cytochrome P450 enzymes in drug metabolism?

Catalyzing drug biotransformation Signup and view all the answers

What is the effect of one drug on the activity of another drug through enzyme induction?

Increased activity of the second drug's metabolizing enzyme Signup and view all the answers