18 Questions
Where are Cytochrome P450 enzymes primarily localized?
Smooth endoplasmic reticulum
What percentage of all drugs commonly introduced to the human body are metabolized by Cytochrome P450 enzymes?
75%
What is the effect referred to when several agents stimulate drug metabolizing agents in liver microsomes?
Induction
What is the term for when the effect of one drug is diminished or completely abolished in the presence of another?
Antagonism
Which of the following CYP450 enzymes is NOT involved in drug metabolism?
CYP2C20
What is the effect of Phenobarbitone on the metabolism of bishydroxycoumarin?
Increases the metabolism
What is the primary function of the rough endoplasmic reticulum (ER) in drug metabolism?
Protein synthesis
What type of enzymes are found in microsomes and catalyze Phase I reactions?
Mixed function oxidases/monooxygenases
What is the result of Phase I reactions in drug metabolism?
The drug becomes more water-soluble
What is the result of Phase II reactions in drug metabolism?
The drug becomes more water-soluble and is readily excreted in urine
What is the main organ responsible for drug metabolism?
Liver
What is the name of the enzyme system that is the most important of the monooxygenases?
Cytochrome P450
What is the primary location where drugs are metabolized?
Liver
What is the result of enzyme induction in drug metabolism?
Enhanced metabolizing enzyme activity
What is the consequence of drug metabolism occurring too slowly?
Toxic side effects
What is the effect of liver disease on drug metabolism?
Complex effects on drug clearance and biotransformation
What is the role of Cytochrome P450 enzymes in drug metabolism?
Catalyzing drug biotransformation
What is the effect of one drug on the activity of another drug through enzyme induction?
Increased activity of the second drug's metabolizing enzyme
Learn about the Cytochrome P450 enzyme system, a large family of multi-functional enzymes primarily localized in the liver, involved in the metabolism of many drugs. Understand the main CYP450 enzymes involved in drug metabolism.
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