Podcast
Questions and Answers
Where are Cytochrome P450 enzymes primarily localized?
Where are Cytochrome P450 enzymes primarily localized?
- Lysosomes
- Rough endoplasmic reticulum
- Golgi apparatus
- Smooth endoplasmic reticulum (correct)
What percentage of all drugs commonly introduced to the human body are metabolized by Cytochrome P450 enzymes?
What percentage of all drugs commonly introduced to the human body are metabolized by Cytochrome P450 enzymes?
- 90%
- 75% (correct)
- 50%
- 60%
What is the effect referred to when several agents stimulate drug metabolizing agents in liver microsomes?
What is the effect referred to when several agents stimulate drug metabolizing agents in liver microsomes?
- Antagonism
- Inhibition
- Induction (correct)
- Synergism
What is the term for when the effect of one drug is diminished or completely abolished in the presence of another?
What is the term for when the effect of one drug is diminished or completely abolished in the presence of another?
Which of the following CYP450 enzymes is NOT involved in drug metabolism?
Which of the following CYP450 enzymes is NOT involved in drug metabolism?
What is the effect of Phenobarbitone on the metabolism of bishydroxycoumarin?
What is the effect of Phenobarbitone on the metabolism of bishydroxycoumarin?
What is the primary function of the rough endoplasmic reticulum (ER) in drug metabolism?
What is the primary function of the rough endoplasmic reticulum (ER) in drug metabolism?
What type of enzymes are found in microsomes and catalyze Phase I reactions?
What type of enzymes are found in microsomes and catalyze Phase I reactions?
What is the result of Phase I reactions in drug metabolism?
What is the result of Phase I reactions in drug metabolism?
What is the result of Phase II reactions in drug metabolism?
What is the result of Phase II reactions in drug metabolism?
What is the main organ responsible for drug metabolism?
What is the main organ responsible for drug metabolism?
What is the name of the enzyme system that is the most important of the monooxygenases?
What is the name of the enzyme system that is the most important of the monooxygenases?
What is the primary location where drugs are metabolized?
What is the primary location where drugs are metabolized?
What is the result of enzyme induction in drug metabolism?
What is the result of enzyme induction in drug metabolism?
What is the consequence of drug metabolism occurring too slowly?
What is the consequence of drug metabolism occurring too slowly?
What is the effect of liver disease on drug metabolism?
What is the effect of liver disease on drug metabolism?
What is the role of Cytochrome P450 enzymes in drug metabolism?
What is the role of Cytochrome P450 enzymes in drug metabolism?
What is the effect of one drug on the activity of another drug through enzyme induction?
What is the effect of one drug on the activity of another drug through enzyme induction?
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