Ch 17
65 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the stimulus that triggers the body's response to low blood oxygen levels?

  • Hypoxia (correct)
  • Increased blood pressure
  • Increased heart rate
  • Decreased blood sugar levels
  • Which organ is primarily responsible for secreting erythropoietin in response to low blood oxygen levels?

  • Spleen
  • Pancreas
  • Kidney (correct)
  • Liver
  • What is the direct effect of erythropoietin on red blood cell production?

  • Inhibits the production of hemoglobin in red blood cells
  • Increases the production of white blood cells
  • Decreases the production of platelets
  • Stimulates red blood cell production in the bone marrow (correct)
  • What is one potential cause of hypoxia, leading to the release of erythropoietin?

    <p>Decreased red blood cell count (A)</p> Signup and view all the answers

    What is the primary function of red blood cells in the body?

    <p>To transport oxygen (D)</p> Signup and view all the answers

    In what type of blood vessel do oxygen and nutrients diffuse across capillary walls and into organs?

    <p>Capillaries (C)</p> Signup and view all the answers

    What is the non-living fluid matrix of blood called?

    <p>Plasma (A)</p> Signup and view all the answers

    What is the main function of erythrocytes?

    <p>Transporting oxygen (A)</p> Signup and view all the answers

    What is the Buffy coat composed of?

    <p>Leukocytes and platelets (C)</p> Signup and view all the answers

    What is hematocrit?

    <p>The percentage of blood volume that is red blood cells (B)</p> Signup and view all the answers

    What is the approximate hematocrit range for males?

    <p>47% ± 5% (B)</p> Signup and view all the answers

    Which of the following is NOT a formed element of blood?

    <p>Plasma (B)</p> Signup and view all the answers

    What is the function of platelets in blood?

    <p>Clotting blood (C)</p> Signup and view all the answers

    What is the direct stimulus for erythropoiesis?

    <p>Erythropoietin (EPO) (B)</p> Signup and view all the answers

    What is the main role of the Buffy coat layer in blood?

    <p>Containing white blood cells and platelets (B)</p> Signup and view all the answers

    What is the key difference between plasma and the Buffy coat?

    <p>Plasma is a fluid component, and the Buffy coat is a solid component. (C)</p> Signup and view all the answers

    Which of the following factors can lead to an increase in erythropoietin production?

    <p>High altitudes (C)</p> Signup and view all the answers

    What is the direct consequence of increased erythropoietin levels in the blood?

    <p>Increased red blood cell production (B)</p> Signup and view all the answers

    Which of the following is a potential danger associated with abusing artificial EPO?

    <p>Increased risk of blood clots (C)</p> Signup and view all the answers

    Which of the following conditions can lead to decreased red blood cell production?

    <p>Hemorrhage (C)</p> Signup and view all the answers

    How does testosterone influence red blood cell production?

    <p>Testosterone enhances the production of erythropoietin. (B)</p> Signup and view all the answers

    Which of the following is NOT a typical symptom of anemia?

    <p>Increased energy (A)</p> Signup and view all the answers

    Which type of anemia is caused by a lack of intrinsic factor, leading to a deficiency of vitamin B12?

    <p>Pernicious anemia (B)</p> Signup and view all the answers

    What is the primary treatment for iron-deficiency anemia?

    <p>Iron supplements (C)</p> Signup and view all the answers

    Which of the following is NOT a cause of hemolytic anemia?

    <p>Iron deficiency (B)</p> Signup and view all the answers

    What causes sickle-cell anemia?

    <p>A genetic mutation in the globin beta chain (C)</p> Signup and view all the answers

    Which of the following is a characteristic of sickle-cell anemia?

    <p>Crescent-shaped red blood cells (A)</p> Signup and view all the answers

    What is the function of transferrin?

    <p>Transporting iron in the blood (A)</p> Signup and view all the answers

    What is the primary pigment that results from the breakdown of heme?

    <p>Bilirubin (D)</p> Signup and view all the answers

    Which type of anemia is often associated with renal disease?

    <p>Renal anemia (C)</p> Signup and view all the answers

    What are thalassemias?

    <p>A group of genetic disorders affecting the production of globin chains (C)</p> Signup and view all the answers

    Which of the following is NOT a reason why a person might experience a low blood oxygen level (hypoxia) leading to an increase in erythropoietin production?

    <p>Increased production of red blood cells (A)</p> Signup and view all the answers

    What is the primary effect of erythropoietin on red blood cell production?

    <p>Directly stimulates red blood cell maturation and division (D)</p> Signup and view all the answers

    Which organ is primarily responsible for secreting erythropoietin?

    <p>Kidneys (D)</p> Signup and view all the answers

    What is a potential danger associated with the abuse of artificial erythropoietin (EPO)?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following is a possible cause for decreased red blood cell production?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following situations would NOT lead to an increased production of erythropoietin?

    <p>Increased red blood cell count (B)</p> Signup and view all the answers

    What is the primary role of "intrinsic factor" in the absorption of vitamin B12?

    <p>Intrinsic factor acts as a carrier molecule, facilitating the absorption of vitamin B12 across the intestinal wall. (D)</p> Signup and view all the answers

    Which of the following is a key difference between plasma and the Buffy coat?

    <p>Plasma is the fluid component of blood, while the Buffy coat comprises formed elements. (C)</p> Signup and view all the answers

    Which of the following conditions is NOT a cause of low red blood cell production (low RBC production)?

    <p>Hemolytic anemia (A)</p> Signup and view all the answers

    In what scenario would an increase in reticulocytes likely be observed?

    <p>After a significant blood loss (D)</p> Signup and view all the answers

    Which of the following best describes the characteristics of red blood cells in iron-deficiency anemia?

    <p>Small, pale red blood cells with a low hemoglobin content. (C)</p> Signup and view all the answers

    What is the main function of transferrin in the body?

    <p>To transport iron in the bloodstream. (A)</p> Signup and view all the answers

    What is the primary consequence of a lack of erythropoietin (EPO) production in the body?

    <p>Reduced red blood cell production (D)</p> Signup and view all the answers

    Which of the following is a potential cause of aplastic anemia?

    <p>Exposure to certain drugs or chemicals (A)</p> Signup and view all the answers

    What is the primary physiological mechanism responsible for the sickle shape of red blood cells in individuals with sickle-cell anemia?

    <p>A genetic mutation affecting a single amino acid in hemoglobin (D)</p> Signup and view all the answers

    Which of the following types of anemia is often associated with renal disease?

    <p>Renal anemia (B)</p> Signup and view all the answers

    What is the primary treatment strategy for pernicious anemia?

    <p>Vitamin B12 injections or nasal gel (D)</p> Signup and view all the answers

    What is the approximate percentage of blood volume that is erythrocytes?

    <p>40% - 50% (D)</p> Signup and view all the answers

    What happens to oxygen and nutrients in the capillaries?

    <p>They diffuse across capillary walls and into the surrounding organs (B)</p> Signup and view all the answers

    Which of the following is TRUE about the Buffy coat?

    <p>It is the top layer of a centrifuged blood sample (B)</p> Signup and view all the answers

    Which of the following describes the flow of blood through the circulatory system?

    <p>Heart -&gt; Arteries -&gt; Capillaries -&gt; Veins -&gt; Heart (B)</p> Signup and view all the answers

    What is the primary function of blood plasma?

    <p>Transport nutrients and waste products (A)</p> Signup and view all the answers

    Which of the following is NOT a component of blood?

    <p>Lymphatic fluid (D)</p> Signup and view all the answers

    What is the role of capillaries in the circulation system?

    <p>To facilitate the exchange of gases and nutrients between blood and tissues (D)</p> Signup and view all the answers

    What is the primary physiological consequence of the imbalance in the blood oxygen levels, as depicted in the diagram?

    <p>Reduced oxygen carrying capacity due to decreased red blood cell production. (D)</p> Signup and view all the answers

    How does the body compensate for the imbalance in oxygen delivery, as shown in the diagram?

    <p>By increasing the production of red blood cells to enhance oxygen carrying capacity. (B)</p> Signup and view all the answers

    What is the primary role of the kidney in the body's response to low blood oxygen levels, as shown in the diagram?

    <p>To produce erythropoietin, which stimulates red blood cell production. (B)</p> Signup and view all the answers

    What is the physiological consequence of enhanced erythropoiesis in response to the imbalance in oxygen levels, shown in the diagram?

    <p>Increased blood viscosity, potentially leading to circulatory issues. (D)</p> Signup and view all the answers

    Which of the following scenarios could potentially trigger the cascade of events depicted in the diagram, resulting in enhanced erythropoiesis?

    <p>A prolonged period of high altitude exposure. (A)</p> Signup and view all the answers

    What is the primary function of the red bone marrow as depicted in the diagram, in response to the imbalance in blood oxygen levels?

    <p>It produces red blood cells, which carry oxygen throughout the body. (A)</p> Signup and view all the answers

    Which of the following would NOT directly contribute to the imbalance in blood oxygen levels, as depicted in the diagram?

    <p>An increase in blood plasma volume, diluting the concentration of red blood cells. (A)</p> Signup and view all the answers

    What is the reason for the rise in the O2-carrying ability of blood, as depicted in the diagram, in response to the imbalance in oxygen delivery?

    <p>Increased production of red blood cells, which carry oxygen throughout the body. (B)</p> Signup and view all the answers

    What is the primary mechanism by which erythropoietin stimulates red blood cell production, as depicted in the diagram?

    <p>By directly activating the bone marrow cells responsible for red blood cell synthesis. (A)</p> Signup and view all the answers

    How does the imbalance in blood oxygen levels depicted in the diagram, lead to a change in the oxygen-carrying ability of blood?

    <p>Increased production of red blood cells, enhancing the blood's ability to carry oxygen. (C)</p> Signup and view all the answers

    Flashcards

    Homeostasis

    The state of stable internal conditions in the body, like normal blood oxygen levels.

    Hypoxia

    A condition where there is inadequate oxygen delivery to tissues.

    Erythropoiesis

    The process of producing red blood cells (RBCs) in the body.

    Erythropoietin

    A hormone released by the kidneys that stimulates the production of red blood cells.

    Signup and view all the flashcards

    RBC Count

    The number of red blood cells present in a volume of blood.

    Signup and view all the flashcards

    Erythropoiesis Nutrients

    Amino acids, lipids, carbohydrates, iron, B12, and folic acid required for red blood cell formation.

    Signup and view all the flashcards

    Iron in Erythropoiesis

    65% of iron is in hemoglobin; stored as ferritin and hemosiderin; transported by transferrin.

    Signup and view all the flashcards

    Erythrocyte Life Span

    Red blood cells have a life span of 100-120 days before degradation.

    Signup and view all the flashcards

    Anemia Definition

    Condition where blood has low oxygen-carrying capacity, leading to fatigue and pallor.

    Signup and view all the flashcards

    Causes of Anemia

    Grouped into three categories: blood loss, low RBC production, and high RBC destruction.

    Signup and view all the flashcards

    Iron-deficiency Anemia

    Low RBC production due to low iron intake or absorption, resulting in microcytic and hypochromic RBCs.

    Signup and view all the flashcards

    Pernicious Anemia

    Autoimmune disorder leading to B12 deficiency due to intrinsic factor loss; causes macrocytic RBCs.

    Signup and view all the flashcards

    Hemolytic Anemia

    Characterized by premature RBC destruction due to abnormalities or infections.

    Signup and view all the flashcards

    Sickle-cell Anemia

    Genetic disorder causing RBCs to form a crescent shape; leads to blockage and pain due to low O2.

    Signup and view all the flashcards

    Thalassemias

    Genetic condition with abnormal globin chains, leading to fragile RBCs with reduced hemoglobin.

    Signup and view all the flashcards

    Circulation

    Movement of blood through the heart, arteries, capillaries, and veins.

    Signup and view all the flashcards

    Capillaries

    Tiny blood vessels that are 1 cell thick, where oxygen and nutrients diffuse into organs.

    Signup and view all the flashcards

    Blood Plasma

    Non-living fluid matrix that transports cells, nutrients, and waste in blood.

    Signup and view all the flashcards

    Erythrocytes

    Red blood cells (RBCs) responsible for carrying oxygen to tissues.

    Signup and view all the flashcards

    Leukocytes

    White blood cells (WBCs) that protect the body against infection.

    Signup and view all the flashcards

    Hematocrit

    The percentage of blood volume that is made up of red blood cells.

    Signup and view all the flashcards

    Veins

    Blood vessels that return oxygen-deficient blood to the heart.

    Signup and view all the flashcards

    Buffy Coat

    The thin layer of white blood cells and platelets in a spun tube of blood, less than 1% of volume.

    Signup and view all the flashcards

    Plasma

    The liquid component of blood, making up 55% of whole blood.

    Signup and view all the flashcards

    Erythropoietin (EPO)

    A hormone that stimulates red blood cell production in response to low oxygen.

    Signup and view all the flashcards

    Effects of EPO

    EPO causes rapid maturation of red blood cell precursors and raises reticulocyte count.

    Signup and view all the flashcards

    Testosterone's effect on EPO

    Testosterone boosts EPO production, leading to increased red blood cell counts in males.

    Signup and view all the flashcards

    Causes of hypoxia

    Hypoxia can occur from low RBC numbers, hemoglobin deficiencies, or less oxygen availability.

    Signup and view all the flashcards

    Arteries

    Blood vessels that carry blood away from the heart.

    Signup and view all the flashcards

    Blood Composition

    Made of plasma (55%) and formed elements like RBCs, WBCs, and platelets.

    Signup and view all the flashcards

    Platelets

    Cell fragments that help in blood clotting.

    Signup and view all the flashcards

    Plasma Composition

    The liquid part of blood that constitutes 55% of total blood volume.

    Signup and view all the flashcards

    RBC Production Rate

    2 million red blood cells (RBCs) are produced per second.

    Signup and view all the flashcards

    EPO Basal Level

    Erythropoietin is always present in small amounts to maintain normal RBC levels.

    Signup and view all the flashcards

    EPO Response to Hypoxia

    EPO is released by kidneys in response to low oxygen or RBC levels.

    Signup and view all the flashcards

    EPO Effects

    EPO causes rapid maturation of RBC precursors and raises reticulocyte counts quickly.

    Signup and view all the flashcards

    Dialysis and RBC Counts

    Dialysis patients often have low RBC counts due to reduced EPO production.

    Signup and view all the flashcards

    Testosterone's Role

    Testosterone enhances EPO production, resulting in higher RBC counts in males.

    Signup and view all the flashcards

    Rapid Reticulocyte Count Increase

    EPO can lead to an increased reticulocyte count within 1-2 days.

    Signup and view all the flashcards

    Imbalance in Homeostasis

    A disruption in the stable internal state, like low oxygen levels.

    Signup and view all the flashcards

    Hypoxia Causes

    Factors leading to inadequate oxygen delivery to tissues include low RBC count or hemoglobin.

    Signup and view all the flashcards

    Enhanced Erythropoiesis

    Increased production of red blood cells to correct low oxygen levels in the blood.

    Signup and view all the flashcards

    Stimulus for Erythropoiesis

    Hypoxia acts as a stimulus for enhancing the production of red blood cells.

    Signup and view all the flashcards

    Kidney Response to Hypoxia

    The kidneys detect low oxygen and release erythropoietin to stimulate RBC production.

    Signup and view all the flashcards

    Erythropoietin Function

    Hormone that stimulates the bone marrow to produce red blood cells in response to low oxygen.

    Signup and view all the flashcards

    Role of Liver in EPO

    The liver plays a minor role in the secretion of erythropoietin during hypoxia.

    Signup and view all the flashcards

    Consequences of Low RBC Count

    Inadequate RBCs lead to insufficient oxygen delivery, resulting in fatigue and other symptoms.

    Signup and view all the flashcards

    Normal Blood Oxygen Levels

    The ideal state where the blood is adequately saturated with oxygen for bodily functions.

    Signup and view all the flashcards

    Enhanced RBC Production Trigger

    Low oxygen levels trigger the body to enhance red blood cell production through erythropoiesis.

    Signup and view all the flashcards

    Ferritin

    Iron storage protein found in cells.

    Signup and view all the flashcards

    Hemosiderin

    Storage form of iron, less bioavailable than ferritin.

    Signup and view all the flashcards

    Bilirubin

    Yellow pigment formed from heme degradation.

    Signup and view all the flashcards

    Urobilinogen

    Product of bilirubin breakdown in intestines.

    Signup and view all the flashcards

    Hemorrhagic Anemia

    Anemia caused by rapid blood loss.

    Signup and view all the flashcards

    Renal Anemia

    Anemia caused by insufficient erythropoietin (EPO).

    Signup and view all the flashcards

    Aplastic Anemia

    Inhibition of red bone marrow leading to low RBCs.

    Signup and view all the flashcards

    Sickle-Cell Trait

    Having one sickle-cell gene providing some malaria resistance.

    Signup and view all the flashcards

    Anemia Symptoms

    Fatigue, pallor, shortness of breath, and chills.

    Signup and view all the flashcards

    Study Notes

    Blood Composition and Functions

    • Blood is a fluid connective tissue.
    • Plasma is the non-living fluid matrix.
    • Formed elements are living cells suspended in plasma.
    • Erythrocytes (red blood cells, or RBCs): transport oxygen and carbon dioxide.
    • Leukocytes (white blood cells, or WBCs): function in defense against disease.
    • Platelets (cell fragments): involved in blood clotting.

    Blood Circulation

    • Blood exits the heart via arteries, moving away from the heart.
    • Arteries branch into capillaries, where oxygen and nutrients diffuse across capillary walls and into organs.
    • Carbon dioxide and waste from organs enter the bloodstream.
    • Oxygen-deficient blood leaves the capillaries and flows into veins.
    • Veins return blood to the heart.

    Blood Plasma

    • Blood plasma is mostly water (approximately 90%).
    • Over 100 dissolved solutes, including nutrients, gases, hormones, wastes, proteins, and inorganic ions.
    • Plasma proteins are the most abundant solutes.
    • They remain in the blood and aren't absorbed by cells.
    • Plasma proteins are largely produced within the liver.
    • Albumin (60%), globulins (36%), and fibrinogen (4%) are important plasma proteins.

    Formed Elements: Erythrocytes (RBCs)

    • Primarily biconcave discs, anucleate (no nucleus), and have few organelles.
    • Contain hemoglobin (Hb): crucial for oxygen transport.
    • Diameters of RBCs are larger than some capillaries.
    • Contain spectrin and other proteins, enabling flexibility to change shape to pass through narrow capillaries.
    • The biconcave shape maximizes surface area for efficient gas exchange.
    • RBCs are primarily responsible for transporting oxygen.

    Formed Elements: Erythrocytes - Structure and Function

    • Structural characteristics contribute to gas transport.
    • Biconcave shape—huge surface area relative to volume.
    • Contain >97% hemoglobin.
    • No mitochondria; anaerobic ATP production; lack of oxygen consumption which allows Hb to transport more oxygen and avoid using the oxygen itself.
    • Superb example of complementarity of structure and function.

    Formed Elements: Erythrocytes - Function

    • RBCs are primarily responsible for respiratory gas transport.
    • Hemoglobin binds reversibly with oxygen.
    • Normal values: males (13-18 g/100 mL), females (12-16 g/100 mL).

    Formed Elements: Hemoglobin Structure (Hb)

    • Composed of 4 polypeptide chains (2 alpha and 2 beta chains) and heme pigment.
    • Each hemoglobin molecule binds up to 4 oxygen molecules.
    • Iron in heme gives blood its red color.

    Formed Elements: Hemoglobin (Hb)

    • O2 loading in lungs: produces oxyhemoglobin (ruby red).
    • O2 unloading in tissues: produces deoxyhemoglobin (dark red).
    • CO2 loading in tissues: 20% of CO2 in blood binds to Hb, forming carbaminohemoglobin.

    Formed Elements: Hematopoiesis

    • Blood cell formation occurs in red bone marrow.
    • Composed of reticular connective tissue and blood sinusoids.
    • In adults, found in the axial skeleton, girdles, and proximal epiphyses of humerus and femur.
    • Hematopoietic stem cells (hemocytoblasts) give rise to all formed elements.
    • Hormones and growth factors direct cell development.

    Formed Elements: Erythropoiesis (RBC Production)

    • Myeloid stem cell transforms into a proerythroblast.
    • In 15 days, proerythroblasts develop into basophilic, polychromatic, orthochromatic erythroblasts, and then into reticulocytes.
    • Reticulocytes enter the bloodstream and mature into RBCs.
    • Hemoglobin is synthesized, and iron accumulates.
    • The nucleus is ejected.
    • Reticulocyte ribosomes degrade; mature erythrocytes are produced.

    Formed Elements: Erythropoiesis Regulation

    • Too few RBCs: tissue hypoxia.
    • Too many RBCs: increased blood viscosity.
    • Balance between RBC production and destruction depends on hormonal controls and adequate supplies of iron, amino acids, and B vitamins.

    Formed Elements: Erythropoiesis Regulation: Hormones

    • Erythropoietin (EPO): a direct stimulus for erythropoiesis, released by kidneys (some by the liver) in response to hypoxia.
    • High RBC or O2 levels depress EPO production.
    • Causes of hypoxia: decreased RBC numbers, insufficient hemoglobin, reduced availability of O2.

    Formed Elements: Erythrocyte Fate and Destruction

    • Life span: 100-120 days.
    • No protein synthesis, growth, or division.
    • Old RBCs become fragile, with Hb beginning to degenerate.
    • Trapped in smaller circulatory channels, especially in the spleen.
    • Macrophages engulf dying RBCs.

    Formed Elements: Erythrocyte Fate and Destruction (cont.)

    • Heme and globin are separated.
    • Iron is salvaged for reuse.
    • Heme degrades into bilirubin (yellow pigment).
    • Bilirubin is secreted into intestines.
    • Degradation products become urobilinogen.
    • Pigment leaves the body in feces as stercobilin.
    • Globin metabolized into amino acids, released into circulation.

    Formed Elements: Leukocytes (WBCs)

    • Make up <1% of total blood volume.
    • Normal values: 4,800–10,800 WBCs/µL blood.
    • Function in defense against disease.
    • Can leave capillaries via diapedesis.

    Formed Elements: Leukocytes (WBCs) - Types and Categories

    • Two categories: granulocytes and agranulocytes.
    • Granulocytes: visible cytoplasmic granules; include neutrophils, eosinophils, and basophils.
    • Agranulocytes: no visible cytoplasmic granules; include lymphocytes and monocytes.
    • Function: defense

    Formed Elements: Leukocytes: Granulocytes

    • Larger and shorter-lived than RBCs.
    • Have lobed nuclei.
    • Cytoplasmic granules stain specifically with Wright's stain.
    • All are phagocytic to some degree.

    Formed Elements: Leukocytes: Neutrophils

    • Most numerous WBCs.
    • Also called polymorphonuclear leukocytes (PMNs or polys).
    • Granules stain lilac, containing hydrolytic enzymes (like lysozymes) or defensins.
    • 3–6 lobes in nucleus; twice the size of RBCs.
    • Very phagocytic ("bacteria slayers").

    Formed Elements: Leukocytes: Eosinophils

    • Red-staining granules.
    • Bilobed nucleus.
    • Granules are lysosome-like; release enzymes to digest parasitic worms.
    • Play a role in allergies and asthma, and defense against parasites and allergens

    Formed Elements: Leukocytes: Basophils

    • Rarest WBCs.
    • Nucleus deep purple, with 1-2 constrictions.
    • Large, purplish-black (basophilic) granules contain histamine.
    • Histamine acts as a vasodilator and attracts WBCs to inflamed sites.
    • Functionally similar to mast cells

    Formed Elements: Leukocytes: Agranulocytes

    • Lack visible cytoplasmic granules.
    • Spherical or kidney-shaped nuclei.

    Formed Elements: Leukocytes: Lymphocytes

    • Second most numerous WBCs.
    • Large, dark-purple circular nuclei with a thin rim of blue cytoplasm.
    • Mostly in lymphoid tissue (e.g., lymph nodes, spleen).
    • Crucial for immunity; part of the adaptive immune system.

    Formed Elements: Leukocytes: Lymphocytes (Types)

    • T lymphocytes (T cells): target virus-infected cells and tumor cells via cell-mediated immunity.
    • B lymphocytes (B cells): give rise to plasma cells, producing antibodies via humoral immunity.

    Formed Elements: Leukocytes: Monocytes

    • Largest leukocytes.
    • Abundant pale-blue cytoplasm.
    • Dark-purple-staining U- or kidney-shaped nuclei.
    • Leave circulation, entering tissues, and differentiate into macrophages.
    • Phagocytic cells crucial against viruses, intracellular bacterial parasites, and chronic infections; part of the innate immune system.

    Formed Elements: Leukocytes: Leukopoiesis

    • Production of WBCs is stimulated by chemical messengers from red bone marrow and mature WBCs.
    • Includes two types of chemical messengers: interleukins (e.g., IL-3, IL-5) and colony-stimulating factors (CSFs).
    • All leukocytes originate from hemocytoblasts.

    Formed Elements: Platelets

    • Cytoplasmic fragments of megakaryocytes.
    • Blue-staining outer region; purple granules contain serotonin, Ca2+, enzymes, ADP, and platelet-derived growth factor (PDGF).
    • Act in clotting processes.
    • Normal values: 150,000–400,000 platelets/mL blood.

    Formed Elements: Platelets (cont.)

    • Form temporary platelet plugs to seal breaks in blood vessels.
    • Kept inactive and mobile by nitric oxide (NO) and prostacyclin from endothelial cells.
    • Age quickly, degenerating within about 10 days.
    • Formation is regulated by thrombopoietin.

    Hemostasis and Blood Replacement

    • Fast series of reactions for stopping bleeding (vasoconstriction, platelet plug formation, coagulation).
    • Requires clotting factors and substances released by platelets and injured tissues.
    • Includes three overlapping steps: vascular spasm, platelet plug formation, and coagulation.

    Hemostasis: Coagulation Overview

    • Reinforces the platelet plug with fibrin threads.
    • Converts blood from liquid to a gel.
    • Uses a series of reactions using clotting factors (procoagulants).
    • Most plasma proteins are needed.
    • Vitamin K is necessary for the synthesis of particular clotting factors.

    Hemostasis: Coagulation: Phase 1 - Prothrombin Activator

    • Two pathways (intrinsic and extrinsic) initiate coagulation, forming prothrombin activator.
    • Intrinsic: involved within blood, triggered by negatively charged surfaces (activated platelets, collagen, glass).
    • Extrinsic: triggered by tissue factor (TF or factor III), bypassing several intrinsic steps.

    Hemostasis: Coagulation: Phase 2 - Pathway to Thrombin

    • Prothrombin activator triggers the transformation of prothrombin to active enzyme thrombin.
    • Clot formation occurs within 10-15 seconds.

    Hemostasis: Coagulation: Phase 3 - Common Pathway to Fibrin Mesh

    • Thrombin converts soluble fibrinogen to insoluble fibrin.
    • Fibrin forms the structural basis of the clot; entraps formed elements.
    • Thrombin, with calcium, activates factor XIII, which cross-links fibrin, making the clot stronger and more stable.

    Hemostasis: Clot Retraction

    • Stabilizes the clot.
    • Actin and myosin in platelets contract within 30-60 minutes.
    • Contraction pulls on fibrin strands, squeezing serum from the clot.
    • Draws ruptured blood vessel edges together.

    Hemostasis: Vessel Repair

    • Vessel healing takes place during clot retraction.
    • Platelet-derived growth factor (PDGF) stimulates division of smooth muscle cells and fibroblasts to rebuild the blood vessel wall.
    • Vascular endothelial growth factor (VEGF) stimulates endothelial cells to multiply and restore the endothelial lining.

    Fibrinolysis

    • Removes unneeded clots after healing.
    • Begins within two days and continues for several days.
    • Plasminogen in the clot is converted to plasmin (a fibrin-digesting enzyme) via tissue plasminogen activator (tPA), factor XII, and thrombin.

    Factors Limiting Clot Growth or Formation

    • Swift removal and dilution of clotting factors.
    • Inhibition of activated clotting factors (e.g., thrombin bound onto fibrin threads, Antithrombin III inactivates unbound thrombin).
    • Heparin, in basophils and mast cells, inhibits thrombin by enhancing antithrombin III.

    Factors Preventing Undesirable Clotting

    • Platelet adhesion is prevented by the smooth endothelium preventing platelets from clinging.
    • Antithrombic substances (nitric oxide and prostacyclin) are secreted.
    • Vitamin E quinone acts as a potent anticoagulant.

    Disorders of Hemostasis

    • Thromboembolic disorders: undesirable clot formation.
    • Bleeding disorders: abnormalities preventing normal clot formation.
    • Disseminated intravascular coagulation (DIC): involves both types of disorders.

    Thromboembolic Conditions

    • Thrombus: a clot that forms and persists in unbroken blood vessels.
    • Embolus: a thrombus that freely floats in the bloodstream.
    • Embolism: an embolus obstructing a vessel.
    • Risk factors: atherosclerosis, inflammation, slowly flowing blood (stasis), immobility.

    Anticoagulant Drugs

    • Aspirin: inhibits thromboxane A2.
    • Heparin: anticoagulant used clinically for pre- and postoperative cardiac care.
    • Warfarin (Coumadin): used for those prone to atrial fibrillation; interferes with vitamin K action.
    • Dabigatran: directly inhibits thrombin.

    Bleeding Disorders: Thrombocytopenia

    • Deficient number of circulating platelets.
    • Petechiae appear due to spontaneous, widespread hemorrhage.
    • Due to suppression or destruction of red bone marrow (e.g., malignancy, radiation, drugs).
    • Platelet count < 50,000/µL is diagnostic.
    • Treated with a transfusion of concentrated platelets.

    Bleeding Disorders: Liver Function Impairment

    • Impaired liver function: inability to synthesize procoagulants (e.g., vitamin K deficiency, hepatitis, cirrhosis).
    • Impaired fat absorption can prevent liver from producing bile.
    • This impairs absorption of fat and vitamin K, thus also affecting clotting factors.

    Bleeding Disorders: Hemophilia

    • Includes several similar hereditary bleeding disorders.
    • Hemophilia A: most common; factor VIII deficiency.
    • Hemophilia B: factor IX deficiency.
    • Hemophilia C: mild type; factor XI deficiency.
    • Symptoms: prolonged bleeding, especially into joint cavities.
    • Treated with plasma transfusions and injection of missing factors.

    Bleeding Disorders: Disseminated Intravascular Coagulation (DIC)

    • Clotting causes bleeding.
    • Widespread clotting blocks intact blood vessels.
    • Severe bleeding occurs because residual blood is unable to clot due to the over-consumption of clotting factors.

    Additional Notes

    • Never let monkeys eat bananas: a useful mnemonic for remembering the decreasing abundance of granulocytes in blood (Neutrophils, Eosinophils, Basophils).

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Blood Chapter 17 PDF

    Description

    This quiz focuses on the essential components of human blood, including erythropoietin and the roles of red blood cells. It explores how low oxygen levels trigger responses in the body and the functions of various blood elements. Test your knowledge on hematocrit, platelets, and the structural components of blood!

    More Like This

    Use Quizgecko on...
    Browser
    Browser