Erythropoiesis: Formation of Red Blood Cells

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What is the average circulation time for erythrocytes?

120 days

Which hormone acts on more mature committed stem cells during erythropoiesis?

Erythropoietin

Where is 90% of erythropoietin produced?

Kidneys

What is the first recognizable erythropoietic cell after CFU-E transformation?

<p>Pronormoblast</p> Signup and view all the answers

What does the CFU-E transform into after amplifying divisions and maturational sequences?

<p>Erythroblasts</p> Signup and view all the answers

What percentage of the erythroblasts' volume is occupied by the nucleus?

<p>70%</p> Signup and view all the answers

What happens to the chromatin in an orthochromatic normoblast?

<p>It becomes condensed and pyknotic</p> Signup and view all the answers

What is the final maturation site for erythropoiesis?

<p>Spleen</p> Signup and view all the answers

What substance is needed for erythropoiesis and includes iron, manganese, and cobalt?

<p>Metal</p> Signup and view all the answers

Which organelle is responsible for synthesizing gene product, particularly hemoglobin, in the orthochromatic normoblast?

<p>Ribosomes</p> Signup and view all the answers

What is the primary stimulus for erythropoietin production?

<p>Tissue hypoxia</p> Signup and view all the answers

Which interleukin is involved in the differentiation of basophilic normoblasts?

<p>IL3</p> Signup and view all the answers

What is the role of erythropoietin (EPO) in erythropoiesis?

<p>Stimulate proliferation and differentiation of erythrocytes</p> Signup and view all the answers

From which cell does the reticulocyte originate?

<p>Polychromatic normoblast</p> Signup and view all the answers

What is the initial stage of erythropoiesis where haemoglobin gradually starts to accumulate?

<p>Basophilic normoblast</p> Signup and view all the answers

Which cell is the earliest committed stem cell in erythropoiesis?

<p>BFU-E</p> Signup and view all the answers

What is the role of CFU-E in erythropoiesis?

<p>Arises from the BFU-E</p> Signup and view all the answers

Which phase of mitotic division and maturational phases produces mature erythrocytes?

<p>(Late) orthochromatic normoblast</p> Signup and view all the answers

What is the effect of Erythropoietin (EPO) on committed stem cells during erythropoiesis?

<p>Induce proliferation, differentiation and maturation of erythrocytes in the bone marrow</p> Signup and view all the answers

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