Podcast
Questions and Answers
What is the male to female ratio for ankylosing spondylitis?
What is the male to female ratio for ankylosing spondylitis?
What is the typical age of onset for ankylosing spondylitis?
What is the typical age of onset for ankylosing spondylitis?
Which joint is least likely to be affected in ankylosing spondylitis?
Which joint is least likely to be affected in ankylosing spondylitis?
What is the association between HLA-B*27 and ankylosing spondylitis?
What is the association between HLA-B*27 and ankylosing spondylitis?
Signup and view all the answers
What is the predominant feature of ankylosing spondylitis?
What is the predominant feature of ankylosing spondylitis?
Signup and view all the answers
In patients with ankylosing spondylitis (AS), what percentage of individuals are positive for HLA-B27?
In patients with ankylosing spondylitis (AS), what percentage of individuals are positive for HLA-B27?
Signup and view all the answers
What is the main reason for caution in vaccinating individuals with ankylosing spondylitis?
What is the main reason for caution in vaccinating individuals with ankylosing spondylitis?
Signup and view all the answers
What proportion of individuals in the general population have HLA-B27 present?
What proportion of individuals in the general population have HLA-B27 present?
Signup and view all the answers
What is the prognostic value of increased inflammatory markers (ESR/CRP) in ankylosing spondylitis?
What is the prognostic value of increased inflammatory markers (ESR/CRP) in ankylosing spondylitis?
Signup and view all the answers
Is sacroiliitis always attributed to spondyloarthritis (SpA)?
Is sacroiliitis always attributed to spondyloarthritis (SpA)?
Signup and view all the answers
Which of the following is NOT a subtype of spondyloarthritis according to the text?
Which of the following is NOT a subtype of spondyloarthritis according to the text?
Signup and view all the answers
What is the male to female ratio in cases of Ankylosing spondylitis according to the text?
What is the male to female ratio in cases of Ankylosing spondylitis according to the text?
Signup and view all the answers
Which specific type of arthritis is associated with ulcerative colitis and regional enteritis?
Which specific type of arthritis is associated with ulcerative colitis and regional enteritis?
Signup and view all the answers
What is the frequency of spondylitis group diseases compared to rheumatoid arthritis according to the text?
What is the frequency of spondylitis group diseases compared to rheumatoid arthritis according to the text?
Signup and view all the answers
What percentage of those affected by Ankylosing spondylitis are HLA-B*27 individuals according to the text?
What percentage of those affected by Ankylosing spondylitis are HLA-B*27 individuals according to the text?
Signup and view all the answers
What is the prevalence of ankylosing spondylitis (AS) among individuals with no prior psoriasis?
What is the prevalence of ankylosing spondylitis (AS) among individuals with no prior psoriasis?
Signup and view all the answers
What is the conventional paradigm regarding the onset age of psoriasis and Psoriatic Arthritis (PsA)?
What is the conventional paradigm regarding the onset age of psoriasis and Psoriatic Arthritis (PsA)?
Signup and view all the answers
What is the first-line therapy for Ankylosing Spondylitis (AS) and undifferentiated SpA?
What is the first-line therapy for Ankylosing Spondylitis (AS) and undifferentiated SpA?
Signup and view all the answers
What is the key feature that differentiates Enteropathic arthritis from other forms of arthritis?
What is the key feature that differentiates Enteropathic arthritis from other forms of arthritis?
Signup and view all the answers
Which type of arthritis necessitates the access of the terminal ileum during endoscopy for diagnosis?
Which type of arthritis necessitates the access of the terminal ileum during endoscopy for diagnosis?
Signup and view all the answers
What is the recommended approach to vaccination for patients on biologics?
What is the recommended approach to vaccination for patients on biologics?
Signup and view all the answers
What percentage of ankylosing spondylitis (AS) patients are HLA B27 positive?
What percentage of ankylosing spondylitis (AS) patients are HLA B27 positive?
Signup and view all the answers
When should age-appropriate screening be initiated?
When should age-appropriate screening be initiated?
Signup and view all the answers
Is sacroiliitis always indicative of spondyloarthritis (SpA)?
Is sacroiliitis always indicative of spondyloarthritis (SpA)?
Signup and view all the answers
What is the prognostic value of increased inflammatory markers like ESR/CRP?
What is the prognostic value of increased inflammatory markers like ESR/CRP?
Signup and view all the answers
What is the prevalence of psoriatic arthritis?
What is the prevalence of psoriatic arthritis?
Signup and view all the answers
Which of the following joints is least likely to be affected by psoriatic arthritis?
Which of the following joints is least likely to be affected by psoriatic arthritis?
Signup and view all the answers
What skin disease is strongly associated with psoriatic arthritis?
What skin disease is strongly associated with psoriatic arthritis?
Signup and view all the answers
What is the typical onset age for psoriatic arthritis?
What is the typical onset age for psoriatic arthritis?
Signup and view all the answers
Which genetic association is strongly linked to psoriasis and psoriatic arthritis?
Which genetic association is strongly linked to psoriasis and psoriatic arthritis?
Signup and view all the answers
What percentage of individuals with psoriasis may develop psoriatic arthritis?
What percentage of individuals with psoriasis may develop psoriatic arthritis?
Signup and view all the answers
What is a clue for enteropathic arthritis?
What is a clue for enteropathic arthritis?
Signup and view all the answers
What is an important step in the diagnosis of enteropathic arthritis?
What is an important step in the diagnosis of enteropathic arthritis?
Signup and view all the answers
What is a distinguishing feature of enteropathic arthritis?
What is a distinguishing feature of enteropathic arthritis?
Signup and view all the answers
Which type of arthritis may show improvement when the intestinal disease is controlled?
Which type of arthritis may show improvement when the intestinal disease is controlled?
Signup and view all the answers
What is a potential treatment option for enteropathic arthritis?
What is a potential treatment option for enteropathic arthritis?
Signup and view all the answers
Study Notes
Ankylosing Spondylitis
- The male to female ratio for ankylosing spondylitis is 2:1 to 3:1.
- The typical age of onset for ankylosing spondylitis is between 15 and 30 years old.
- The joint least likely to be affected in ankylosing spondylitis is the distal interphalangeal joint.
- There is a strong association between HLA-B*27 and ankylosing spondylitis.
- The predominant feature of ankylosing spondylitis is inflammation in the spine and sacroiliac joints.
- About 80-90% of individuals with ankylosing spondylitis are positive for HLA-B27.
- Vaccination should be approached with caution in individuals with ankylosing spondylitis due to the risk of flare-ups.
- About 8-14% of the general population have HLA-B27 present.
- Increased inflammatory markers like ESR/CRP have some prognostic value in ankylosing spondylitis.
Spondyloarthritis
- Sacroiliitis is not always attributed to spondyloarthritis (SpA).
- Psoriatic arthritis is associated with ulcerative colitis and regional enteritis.
- Spondylitis group diseases have a frequency of about 0.5-1.4% compared to rheumatoid arthritis.
Psoriasis and Psoriatic Arthritis
- About 10-30% of individuals with psoriasis may develop psoriatic arthritis.
- The prevalence of psoriatic arthritis is about 0.25-1.25%.
- The typical onset age for psoriatic arthritis is between 30 and 50 years old.
- Psoriatic arthritis is strongly associated with skin disease psoriasis.
- There is a strong genetic association between HLA-C*06 and psoriasis and psoriatic arthritis.
Enteropathic Arthritis
- Enteropathic arthritis is associated with ulcerative colitis and regional enteritis.
- A key feature that differentiates enteropathic arthritis from other forms of arthritis is the access of the terminal ileum during endoscopy for diagnosis.
- Improvement in intestinal disease can lead to improvement in enteropathic arthritis.
- Corticosteroids are a potential treatment option for enteropathic arthritis.
Vaccination
- Vaccination should be approached with caution in individuals with ankylosing spondylitis and psoriatic arthritis due to the risk of flare-ups.
- Age-appropriate screening should be initiated at an early stage.
Prognostic Value
- Increased inflammatory markers like ESR/CRP have some prognostic value in ankylosing spondylitis and psoriatic arthritis.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge about HLA-B27 and its association with ankylosing spondylitis (AS). This quiz covers topics such as vaccination considerations, malignancy risks, prognostic value, and diagnostic relevance of HLA-B27 in AS.
