History of Circulatory System Discoveries

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What was transfusion generally thought of as, in the 1800s?

A remedy for marital discord

A cure for blood loss

A youth potion for the aged (correct)

A treatment for mental aberration

What did James Blundell attempt in 1818?

Transfusion of cat blood to a human

Transfusion of sheep blood to a human

Human-to-human transfusion (correct)

Reciprocal transfusion to cure marital discord

What did people believe about the characteristics of the blood donor on the recipient?

Rabbit blood would give a person long ears

Cow blood would turn a person into a cow

Sheep blood would make a dog grow wool, hooves, and horns (correct)

Cat blood would make a person feline

What did Landois note about interspecies transfusions?

Red blood cells were hemolyzed in interspecies transfusions Signup and view all the answers

What did Sturli and DeCastello describe in 1902?

The fourth blood group, AB Signup and view all the answers

What complications were 19th-century transfusions plagued by?

Complications of transfusion reactions Signup and view all the answers

Who is credited with the discovery of the circulation of blood as we know it today?

William Harvey Signup and view all the answers

What did Erasistratos envision the heart to be?

A pump Signup and view all the answers

What did Galen believe about the formation of blood in the body?

Blood was formed in the liver, not suspecting that arteries and veins were connected Signup and view all the answers

Who is credited with coining the term "circulation" and believing that veins and arteries were connected by a fine vascular network?

Andrea Cesalpino Signup and view all the answers

Who is credited with performing the first authentic blood transfusion (animal to animal)?

Richard Lower Signup and view all the answers

What is the maximum storage temperature for red blood cells frozen using the low-concentration glycerol technique?

-196°C Signup and view all the answers

What is the main advantage of the high-concentration glycerol technique over the low-concentration glycerol technique?

Requires less time for the freezing process Signup and view all the answers

What is the primary disadvantage of the red blood cell freezing process?

A time-consuming process Signup and view all the answers

What is the primary solution used for the deglycerolization process in the low-concentration glycerol technique?

15% mannitol Signup and view all the answers

What is the maximum shelf-life of red blood cells frozen using the high-concentration glycerol technique?

14 days at 1-6°C using an instrument (closed system) Signup and view all the answers

What is the main purpose of the agglomeration step in the deglycerolization process?

To separate the red blood cells from the plasma proteins Signup and view all the answers

What was advocated as a potentially effective infusion during the time period discussed in the text?

Milk Signup and view all the answers

What led to a 150-year hiatus in transfusion work, according to the text?

Prohibitions and fear of adverse reactions Signup and view all the answers

Who discovered the different blood types and named them A, B, and C (later O)?

Karl Landsteiner Signup and view all the answers

What was the outcome of the incident involving Denis and a man's wife accusing him of poisoning her husband?

Denis was exonerated, and the wife was charged with attempted poisoning Signup and view all the answers

Which organizations laid prohibitions against blood transfusions, according to the text?

The British Royal Society, the French Parliament, and the Vatican Signup and view all the answers

What type of transfusions were done only sporadically in the 18th century, according to the text?

Animal-to-human transfusions Signup and view all the answers

What are the main lipid components of the red blood cell (RBC) membrane?

Phospholipids Signup and view all the answers

Which of the following proteins span the entire RBC membrane from the outer surface to the inner cytoplasmic side?

Glycophorins A, B, C, D and Band 3/Anion Exchanger-1 Signup and view all the answers

History of Circulatory System Discoveries

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