13 Questions
What is the main role of CD8 T cells in immune defense?
Recognizing specific antigen-MHC class I complexes on infected or tumor cells
What is the cytotoxic action of CD8 T cells upon recognition of target cells?
Releasing perforin and granzymes to induce apoptosis in the target cells
In the context of tumors, what is the role of CD8 T cells in immune surveillance?
Targeting and eliminating cells with abnormal growth
What is the function of memory CD8 T cells?
Providing long-term immunity and ensuring a faster response upon reencountering the same pathogen or tumor cells
What type of antigen do CD8 T cells recognize on infected or tumor cells?
MHC class I complexes
Which type of T cells are CD3+ and CD4+?
Helper T lymphocytes and Regulatory T cells
What is the role of CD8 T cells in relation to intracellular microbes?
Killing of cells infected with intracellular microbes
How do helper T cells affect neutrophils' chemotaxis?
Release chemotactic factors to attract neutrophils to infection sites
What is the role of Interleukin-17 (IL-17) in the activation of neutrophils by helper T cells?
Plays a crucial role in activating neutrophils
How do helper T cells affect the phagocytic activity of neutrophils?
Release cytokines that enhance the phagocytic activity of neutrophils
What is the effect of helper T cells on the lifespan of neutrophils?
Prolong the lifespan of neutrophils through released cytokines
What is the overall role of helper T cells in coordinating the immune response?
Orchestrating and regulating the immune response, including the activation and regulation of neutrophils
What is the significance of helper T cells releasing cytokines upon recognizing antigens presented by antigen-presenting cells (APCs)?
Activates and regulates neutrophils to ensure harmonious immune response
Study Notes
CD8 T Cells in Immune Defense
- CD8 T cells play a crucial role in immune defense by recognizing and eliminating infected cells or tumor cells.
- Upon recognition of target cells, CD8 T cells exhibit cytotoxic action, releasing cytotoxins and enzymes that induce apoptosis or cell lysis.
- In the context of tumors, CD8 T cells are responsible for immune surveillance, recognizing and eliminating tumor cells that display tumor-specific antigens.
Antigen Recognition and Memory CD8 T Cells
- CD8 T cells recognize endogenous antigens presented by major histocompatibility complex (MHC) class I molecules on infected or tumor cells.
- Memory CD8 T cells retain the ability to recognize and respond to previously encountered antigens, providing long-term immunity.
CD4 T Cells and Immune Response
- CD4 T cells, also known as helper T cells, are characterized by the surface expression of CD3 and CD4.
- Helper T cells play a central role in coordinating the immune response, influencing the activity of other immune cells, such as neutrophils.
Helper T Cells and Neutrophils
- Helper T cells release cytokines that enhance the chemotaxis of neutrophils, increasing their ability to migrate towards sites of infection.
- Interleukin-17 (IL-17) is a key cytokine released by helper T cells, which activates neutrophils and enhances their antimicrobial activity.
- Helper T cells also increase the phagocytic activity of neutrophils, enabling them to engulf and eliminate pathogens more effectively.
- Furthermore, helper T cells can increase the lifespan of neutrophils, allowing them to persist at the site of infection for longer periods.
Coordinating the Immune Response
- Helper T cells play a crucial role in coordinating the immune response by releasing cytokines that influence the activity of other immune cells.
- The release of cytokines by helper T cells upon recognition of antigens presented by antigen-presenting cells (APCs) is a critical step in the initiation of an immune response.
Learn about the interaction between helper T cells and neutrophils, including the activation of neutrophils through cytokine release and the role of chemotactic factors in guiding neutrophils to infection or inflammation sites.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
