Helper T Cells and Neutrophils Interaction

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What is the main role of CD8 T cells in immune defense?

Recognizing specific antigen-MHC class I complexes on infected or tumor cells

What is the cytotoxic action of CD8 T cells upon recognition of target cells?

Releasing perforin and granzymes to induce apoptosis in the target cells

In the context of tumors, what is the role of CD8 T cells in immune surveillance?

Targeting and eliminating cells with abnormal growth

What is the function of memory CD8 T cells?

Providing long-term immunity and ensuring a faster response upon reencountering the same pathogen or tumor cells

What type of antigen do CD8 T cells recognize on infected or tumor cells?

MHC class I complexes

Which type of T cells are CD3+ and CD4+?

Helper T lymphocytes and Regulatory T cells

What is the role of CD8 T cells in relation to intracellular microbes?

Killing of cells infected with intracellular microbes

How do helper T cells affect neutrophils' chemotaxis?

Release chemotactic factors to attract neutrophils to infection sites

What is the role of Interleukin-17 (IL-17) in the activation of neutrophils by helper T cells?

Plays a crucial role in activating neutrophils

How do helper T cells affect the phagocytic activity of neutrophils?

Release cytokines that enhance the phagocytic activity of neutrophils

What is the effect of helper T cells on the lifespan of neutrophils?

Prolong the lifespan of neutrophils through released cytokines

What is the overall role of helper T cells in coordinating the immune response?

Orchestrating and regulating the immune response, including the activation and regulation of neutrophils

What is the significance of helper T cells releasing cytokines upon recognizing antigens presented by antigen-presenting cells (APCs)?

Activates and regulates neutrophils to ensure harmonious immune response

Study Notes

CD8 T Cells in Immune Defense

  • CD8 T cells play a crucial role in immune defense by recognizing and eliminating infected cells or tumor cells.
  • Upon recognition of target cells, CD8 T cells exhibit cytotoxic action, releasing cytotoxins and enzymes that induce apoptosis or cell lysis.
  • In the context of tumors, CD8 T cells are responsible for immune surveillance, recognizing and eliminating tumor cells that display tumor-specific antigens.

Antigen Recognition and Memory CD8 T Cells

  • CD8 T cells recognize endogenous antigens presented by major histocompatibility complex (MHC) class I molecules on infected or tumor cells.
  • Memory CD8 T cells retain the ability to recognize and respond to previously encountered antigens, providing long-term immunity.

CD4 T Cells and Immune Response

  • CD4 T cells, also known as helper T cells, are characterized by the surface expression of CD3 and CD4.
  • Helper T cells play a central role in coordinating the immune response, influencing the activity of other immune cells, such as neutrophils.

Helper T Cells and Neutrophils

  • Helper T cells release cytokines that enhance the chemotaxis of neutrophils, increasing their ability to migrate towards sites of infection.
  • Interleukin-17 (IL-17) is a key cytokine released by helper T cells, which activates neutrophils and enhances their antimicrobial activity.
  • Helper T cells also increase the phagocytic activity of neutrophils, enabling them to engulf and eliminate pathogens more effectively.
  • Furthermore, helper T cells can increase the lifespan of neutrophils, allowing them to persist at the site of infection for longer periods.

Coordinating the Immune Response

  • Helper T cells play a crucial role in coordinating the immune response by releasing cytokines that influence the activity of other immune cells.
  • The release of cytokines by helper T cells upon recognition of antigens presented by antigen-presenting cells (APCs) is a critical step in the initiation of an immune response.

Learn about the interaction between helper T cells and neutrophils, including the activation of neutrophils through cytokine release and the role of chemotactic factors in guiding neutrophils to infection or inflammation sites.

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