COPY: Haemostasis Part II: Secondary Haemostasis

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What is the role of tissue plasminogen activator (tPA) in clot management?

It induces platelet aggregation.

It activates plasminogen to plasmin. (correct)

It promotes thrombin generation.

It converts fibrin into fibrinogen.

What are the small fragments produced from the breakdown of fibrin called?

Plasminogen

Thrombin

Prothrombin

D-dimers (correct)

How does antithrombin III function in the coagulation process?

It enhances platelet activation.

It converts fibrin into fibrinogen.

It promotes the production of tissue factor.

It acts as an inhibitor of thrombin and certain clotting factors. (correct)

Why do we not experience constant clotting in the body?

Endogenous inhibitors help regulate hemostasis. Signup and view all the answers

Which enzyme is responsible for cleaving fibrinogen into fibrin during the coagulation cascade?

Thrombin Signup and view all the answers

What is the primary pharmacological treatment used after a thrombotic stroke?

Recombinant tPA and plasminogen activators Signup and view all the answers

During haemostasis, what role do nitric oxide and prostacyclin play?

They act as inhibitors of platelet activation. Signup and view all the answers

What happens to the clot once the injury is healed?

It gets removed by fibrinolysis. Signup and view all the answers

What is the primary function of secondary haemostasis?

Strengthening the platelet plug with coagulation factors Signup and view all the answers

Which coagulation factors are dependent on Vitamin K for their synthesis?

Factors II, VII, IX, and X Signup and view all the answers

What occurs first in the secondary haemostasis process?

Expression or release of tissue factor Signup and view all the answers

Which of the following statements about proenzymes is true?

Proenzymes require activation to exert their function. Signup and view all the answers

What is the active form of a coagulation factor denoted by?

a Signup and view all the answers

Which stage is NOT included in the secondary haemostasis process?

Formation of the primary platelet plug Signup and view all the answers

Which pathway does NOT belong to the coagulation cascade?

Respiratory Pathway Signup and view all the answers

What role do activated platelets play in secondary haemostasis?

Expressing phospholipid complexes for coagulation factor binding Signup and view all the answers

What initiates the extrinsic pathway of blood clotting?

Vascular injury Signup and view all the answers

Which component is activated first in the intrinsic pathway?

FXII Signup and view all the answers

What is the primary role of the tissue factor (TF) in the extrinsic pathway?

To bind to FVII and activate the extrinsic tenase complex Signup and view all the answers

Which ion is crucial for the activation of the common pathway in coagulation?

Ca2+ Signup and view all the answers

Which of the following statements about the common pathway is accurate?

It is the final pathway that leads to the formation of FXa Signup and view all the answers

Which cell types are primarily involved in the initiation of the extrinsic pathway?

Endothelial cells, fibroblasts, and platelets Signup and view all the answers

How is FXII activated in the intrinsic pathway?

By contact with negatively charged phospholipids Signup and view all the answers

What is the function of the intrinsic pathway in hemostasis?

To initiate coagulation in response to vascular injury Signup and view all the answers

Which of the following factors is involved in the formation of the intrinsic tenase complex?

FIX Signup and view all the answers

Which process is linked to primary hemostasis in the context of the intrinsic pathway?

Activation of platelets Signup and view all the answers