Questions and Answers
What does M0 indicate in AML classification?
Which characteristics are associated with M2 classification?
What is the definition of M3 in AML?
What percentage of monocytes is characteristic of M5a?
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Which classification is described as 'pure erythroid leukemia'?
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What is a key characteristic of M7?
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What is the inversion associated with M4eo?
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Define the term M4 in AML.
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Study Notes
FAB AML Classification Overview
- M0: Minimal differentiation; >30% myeloid blasts; ≥3% blasts positive for Sudan Black B (SBB) and/or Myeloperoxidase (MPO); >10% cellular maturation; frequent t(8;21) translocation.
Maturation and Types of Myeloid Leukemia
- M2: Recognized for maturation; >30% myeloid blasts; ≥3% of blasts SBB and/or MPO positive; >10% maturation; also shows frequent t(8;21) translocation.
Acute Promyelocytic Leukemia
- M3: Characterized by maturation arrest at promyelocytes; consists of >30% promyelocytes and blasts; linked with t(15;17) translocation.
Acute Myelomonocytic Leukemia (AMML)
- M4: Involves >20% myeloid elements (MPO/SBB) and >20% monocytoid elements (Nonspecific Esterase, NSE); contains >30% blasts and promonocytes.
Variants of AMML
- M4eo: A subtype of AMML with abnormal eosinophils; associated with inversion 16 (Inv(16)).
Monocytic Leukemias
- M5: Dominated by >80% monocytes; >30% monoblasts and promonocytes; Subtypes include:
- M5a: Acute monoblastic leukemia (>80% monoblasts).
- M5b: Acute monocytic leukemia (≥80% monocytes and ≥30% non-erythroid cells are myeloblasts).
Erythroleukemia
- M6a: Erythroleukemia defined by >50% erythroid elements and >30% non-erythroid elements being myeloblasts.
- M6b: Pure erythroid leukemia with >80% immature erythroid elements.
Acute Megakaryoblastic Leukemia
- M7: Characterized by >30% blasts, with over 50% being megakaryocytic (features include basophilic cytoplasm and blebbing); associated with positive markers (ANA, CD61, CD41) and marrow fibrosis; linked to Down syndrome; t(1;22) observed in children with organomegaly.
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Test your knowledge on FAB AML classifications with this quiz. Each flashcard presents unique definitions and characteristics of various myeloid blast types like M0, M2, and M3. Perfect for students and professionals looking to refine their understanding of acute myeloid leukemia classifications.
