AML Classification Overview and FAB Classification

Questions and Answers

If the AML is related to previous treatment, what do you call it?

Therapy related AML

What is the term for AML in a patient with Down Syndrome?

DS-related AML

What are the 4 named chromosomal abnormalities associated with AML?

t(8;21), t(15;17), t(4;11), inv(16)

If there is dysplasia, prior MDS, or MDS-related mutation, what do you call it?

AML with MDS related changes Signup and view all the answers

How do you classify AML if there is no major WHO category it fits into?

AML NOS with FAB classification Signup and view all the answers

What does M0 represent in AML?

AML without differentiation Signup and view all the answers

What does M1 represent in AML?

AML with minimal differentiation Signup and view all the answers

What does M2 represent in AML?

AML with differentiation Signup and view all the answers

M2 is associated with what translocation?

t(8;21) (AML1-ETO) Signup and view all the answers

What is the appearance of M2 blasts?

Auer rods and chloromas Signup and view all the answers

What does M3 represent in AML?

Acute promyelocytic leukemia (APML) Signup and view all the answers

M3 is associated with what translocation?

t(15;17); PML-RARA translocation Signup and view all the answers

How do M3 cells appear?

Basket cells, full of granules and rods Signup and view all the answers

What does M3v represent?

M3 microgranular variant, O/W no difference from M3 Signup and view all the answers

What does M4 represent in AML?

Acute myelomonocytic leukemia Signup and view all the answers

What does M4eo stand for?

AMML with eosinophilic precursors full of basophilic granules; inv(16) Signup and view all the answers

What does M5 represent in AML?

Acute monocytic leukemia Signup and view all the answers

How does infant t(4;11) look on FAB system?

M4 or M5 typically Signup and view all the answers

How does M5 present?

Gingival hyperplasia, chloroma involved, CNS involved Signup and view all the answers

What does M6 represent in AML?

Erythroblastic leukemia Signup and view all the answers

What does M7 represent in AML?

Acute Megakaryocytic leukemia (AMKL) Signup and view all the answers

What is M7 in Downs related to?

Gata-1 Signup and view all the answers

What does M7 in non-downs represent?

t(1;22) Signup and view all the answers

Study Notes

AML Classification Overview

Therapy-related Acute Myeloid Leukemia (AML) arises from previous treatments.
Down Syndrome-related AML is specific to patients with Down Syndrome.
Four significant chromosomal abnormalities in AML:
- t(8;21)
- t(15;17)
- t(4;11)
- inv(16)
No minimum blast count is necessary for the above chromosomal abnormalities.
AML with Myelodysplastic Syndrome (MDS) related changes indicates a history of dysplasia or MDS mutations.
If AML does not fit major WHO categories, it is classified as AML Not Otherwise Specified (NOS) under FAB classification.

FAB Classification of AML

M0:
- AML without differentiation; hard to distinguish from Acute Lymphoblastic Leukemia (ALL).
- Markers: CD 13+, 33+, 117+ (c-kit); absence of lymphoid differentiation.
M1:
- Minimal differentiation with myeloperoxidase positivity (MPO+).
M2:
- Exhibits differentiation.
- Associated with translocation t(8;21) (AML1-ETO).
- Blasts show Auer rods and chloromas.
M3 (Acute Promyelocytic Leukemia - APML):
- Linked to t(15;17) PML-RARA translocation.
- Cells demonstrate basket appearance full of granules and rods.
M3v:
- Microgranular variant of M3 with no significant differences from M3.
M4:
- Acute myelomonocytic leukemia, characterized by at least 20% myeloblasts and common peripheral monocytosis.
M4eo:
- Acute myelomonocytic leukemia with eosinophilic precursors, identified by inv(16).
M5:
- Acute monocytic leukemia presents with gingival hyperplasia, chloroma involvement, and central nervous system (CNS) consequences.
Infant t(4;11):
- Typically categorized under M4 or M5 in the FAB system.
M6:
- Known as erythroblastic leukemia.
M7 (Acute Megakaryocytic Leukemia - AMKL):
- In Down syndrome patients, characterized by Gata-1 mutation.
- In non-Down syndrome patients, associated with translocation t(1;22).

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Description

This quiz covers the classification of Acute Myeloid Leukemia (AML), including therapy-related AML, Down Syndrome-related AML, and the FAB classification system. It highlights significant chromosomal abnormalities and specific subtypes of AML. Test your knowledge on these critical aspects of AML recognition and classification.