Questions and Answers
What does M0 stand for in FAB classifications?
What characterizes M1 in FAB classifications?
Acute Myeloblastic Leukemia without maturation, decreased RBCs, plts, and granulocytes.
What is the defining feature of M2?
Acute Myeloblastic Leukemia with maturation, at least 50% mature cells.
M3 is characterized by immature megakaryocytes and a normal platelet count.
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What are the characteristics of M4?
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What is the features of M5?
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Describe M6.
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What does M7 indicate?
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What are the characteristics of L1?
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What defines L3 in FAB classifications?
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Study Notes
FAB Classifications for Leukemias
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M0: Represents Acute Myeloblastic Leukemia that is undifferentiated with predominantly blast cells. All stains are negative, making classification impossible.
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M1: Characterized as Acute Myeloblastic Leukemia without maturation. Exhibits decreased red blood cells, platelets, and granulocytes due to hypercellularity. Blasts may contain Auer rods, leading to homogeneous white blood cell populations.
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M2: Acute Myeloblastic Leukemia with maturation included, where at least 50% of the cells are mature (promyelocytes). Bone marrow is hypercellular, comprising 30% blasts and 10% promyelocytes, with Auer rods possible.
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M3: Known as Acute Promyelocytic Leukemia, this type has numerous promyelocytes containing Auer rod fragments. Malignant cells appear hypergranular.
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M4: Described as Acute Myelomonocytic/Myelomonoblastic Leukemia, featuring convoluted nuclei. Marrow consists of a minimum of 20% monocytes, 30% blasts, and 20% granulocytes.
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M5: Represents Acute Monocytic Leukemia, which predominates immature monocytes in the marrow, leading to monocyte dominance.
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M6: Defines Erythroleukemia, characterized by normocytic normochromic (NC/NC) red blood cells, nucleated red blood cells (NRBCs), and some blasts. Marrow shows erythroid hyperplasia with 50% erythroid precursors and more than 30% blasts, alongside thrombocytopenia.
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M7: Acute Megakaryocytic Leukemia involves immature megakaryocytes and platelets. Notably, the platelet count may be normal or increased.
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L1: Indicates Acute Lymphoblastic Leukemia with small cells and indistinct nucleoli. Nuclei are regular, with a possibility of clefts; scant cytoplasm is present. This form comprises 75% of acute lymphoblastic leukemia cases in children aged 15 years and younger.
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L3: Refers to Acute Lymphoblastic Leukemia with large cells possessing 1-2 nucleoli and a regular round/oval nucleus. Deeply basophilic and vacuolated cytoplasm is characteristic of this subtype, which comprises 3-5% of all cases (Burkitt-type).
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Test your knowledge on the FAB classifications of leukemias with this flashcard quiz. Each card covers essential definitions and characteristics of different types of Acute Myeloblastic Leukemia. Perfect for students and professionals in the medical field.
