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Anatomy LE 2: Embryology of the Musculoskeletal System

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45 Questions

What is the development of the skeletal system composed of?

Development of cartilage, bone, and joints

What is the embryonic mesoderm divided into?

Segmented and non-segmented areas

What is the term for the paraxial mesoderm that will give rise to the musculoskeletal system?

Somites

What is the development of the muscular system composed of?

Development of striated skeletal, smooth, and cardiac muscle

At what day does the development of striated skeletal muscle begin?

17th day

What is the term for the developmental abnormalities of the axial skeleton?

Malformations of the axial skeleton

What is the stage at which the development of cartilage begins?

18th day

What is the term for the developmental abnormalities of the appendicular skeleton?

Malformations of the appendicular skeleton

What is the stage at which the development of smooth muscle begins?

20th day

What is the congenital anomaly where one half of the vertebra fails to form?

Hemivertebra

What is the most common cause of congenital scoliosis?

Hemivertebra

What happens when the sternal bands fail to grow together in the midline?

Thoracic organs are covered only by skin and soft tissue

What is the result of premature closure of one or more sutures?

Scaphocephaly

Which of the following genes is associated with premature closure of sutures?

All of the above

What is the result of premature closure of the coronal sutures?

Brachycephaly

What is the result of premature closure of the frontal (metopic) suture?

Trigonocephaly

What is the characteristic feature of Microcephaly?

Small head size

What is the name of the condition where the coronal sutures close prematurely on one side only?

Plagiocephaly

From which germ layer do the components of the skeletal system arise?

Mesodermal

At which stage of development does the mesodermal layer lateral to the notochord give rise to paraxial and lateral plate mesoderm?

17th day

What is the term for the intermediate mesoderm that forms the excretory units of the urinary system?

Nephrotome

How many pairs of somites are formed by the end of the 5th week?

42-44

What is the name of the cavity that forms between the somatic and splanchnic mesoderm?

Embryonic coelom

At which stage of development does the paraxial mesoderm form somites?

20th day

How many occipital pairs are formed during development?

4

What happens to the 1st occipital and last 5-7 coccygeal pairs during development?

They disappear

What is the term for the junctional or intermediate mesoderm that connects the segmented somites to the peripheral lateral plate mesoderm?

Nephrotome

What divides the embryo into two mesodermal domains by the end of the 5th week?

The lateral somitic frontier

What types of cells are found in the primaxial domain?

Only somite-derived cells

What is the source of innervation for each myotome?

Spinal nerves derived from the same segment

What defines the border between dermis derived from dermatomes and dermis derived from lateral plate mesoderm?

The lateral somitic frontier

What type of mesoderm gives rise to the muscles of mastication, face, pharynx, and larynx?

Mesodermal cells on the pharyngeal arches

What is the main source of smooth muscle development?

Splanchnic mesoderm

Where do vessels in limbs, head, and body wall derive their muscles from?

Local mesenchyme

What is an exception to the rule that smooth muscles develop from splanchnic mesoderm?

Smooth muscles of the iris

What type of glands are also derived from ectoderm?

Sweat glands

What is the shape of the limb bud during its initial development?

Paddle-shaped

What forms in between the finger or toe rays as the limb develops?

Notches

What is the condition where there is an absence of a digit?

Ectrodactyly

What is the typical occurrence of ectrodactyly?

Unilateral

What is the characteristic of cleft hand and foot?

Fusion of thumb and index fingers and 4th and 5th fingers

At what stage do the limbs extend ventrally and the hand plates and foot plates face each other?

At approximately 48 days

At what stage do the soles of the feet face medially?

At approximately 54 days

At what stage do the elbows point caudally and the knees cranially?

At approximately 56 days

What is the term for the abnormality involving extra fingers or toes?

Polydactyly

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