45 Questions
What is the development of the skeletal system composed of?
Development of cartilage, bone, and joints
What is the embryonic mesoderm divided into?
Segmented and non-segmented areas
What is the term for the paraxial mesoderm that will give rise to the musculoskeletal system?
Somites
What is the development of the muscular system composed of?
Development of striated skeletal, smooth, and cardiac muscle
At what day does the development of striated skeletal muscle begin?
17th day
What is the term for the developmental abnormalities of the axial skeleton?
Malformations of the axial skeleton
What is the stage at which the development of cartilage begins?
18th day
What is the term for the developmental abnormalities of the appendicular skeleton?
Malformations of the appendicular skeleton
What is the stage at which the development of smooth muscle begins?
20th day
What is the congenital anomaly where one half of the vertebra fails to form?
Hemivertebra
What is the most common cause of congenital scoliosis?
Hemivertebra
What happens when the sternal bands fail to grow together in the midline?
Thoracic organs are covered only by skin and soft tissue
What is the result of premature closure of one or more sutures?
Scaphocephaly
Which of the following genes is associated with premature closure of sutures?
All of the above
What is the result of premature closure of the coronal sutures?
Brachycephaly
What is the result of premature closure of the frontal (metopic) suture?
Trigonocephaly
What is the characteristic feature of Microcephaly?
Small head size
What is the name of the condition where the coronal sutures close prematurely on one side only?
Plagiocephaly
From which germ layer do the components of the skeletal system arise?
Mesodermal
At which stage of development does the mesodermal layer lateral to the notochord give rise to paraxial and lateral plate mesoderm?
17th day
What is the term for the intermediate mesoderm that forms the excretory units of the urinary system?
Nephrotome
How many pairs of somites are formed by the end of the 5th week?
42-44
What is the name of the cavity that forms between the somatic and splanchnic mesoderm?
Embryonic coelom
At which stage of development does the paraxial mesoderm form somites?
20th day
How many occipital pairs are formed during development?
4
What happens to the 1st occipital and last 5-7 coccygeal pairs during development?
They disappear
What is the term for the junctional or intermediate mesoderm that connects the segmented somites to the peripheral lateral plate mesoderm?
Nephrotome
What divides the embryo into two mesodermal domains by the end of the 5th week?
The lateral somitic frontier
What types of cells are found in the primaxial domain?
Only somite-derived cells
What is the source of innervation for each myotome?
Spinal nerves derived from the same segment
What defines the border between dermis derived from dermatomes and dermis derived from lateral plate mesoderm?
The lateral somitic frontier
What type of mesoderm gives rise to the muscles of mastication, face, pharynx, and larynx?
Mesodermal cells on the pharyngeal arches
What is the main source of smooth muscle development?
Splanchnic mesoderm
Where do vessels in limbs, head, and body wall derive their muscles from?
Local mesenchyme
What is an exception to the rule that smooth muscles develop from splanchnic mesoderm?
Smooth muscles of the iris
What type of glands are also derived from ectoderm?
Sweat glands
What is the shape of the limb bud during its initial development?
Paddle-shaped
What forms in between the finger or toe rays as the limb develops?
Notches
What is the condition where there is an absence of a digit?
Ectrodactyly
What is the typical occurrence of ectrodactyly?
Unilateral
What is the characteristic of cleft hand and foot?
Fusion of thumb and index fingers and 4th and 5th fingers
At what stage do the limbs extend ventrally and the hand plates and foot plates face each other?
At approximately 48 days
At what stage do the soles of the feet face medially?
At approximately 54 days
At what stage do the elbows point caudally and the knees cranially?
At approximately 56 days
What is the term for the abnormality involving extra fingers or toes?
Polydactyly
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