18 Questions
What part of eculizumab is directed against C5?
Lower part
To kill infected endothelial cells (ECs), what must work in conjunction with activated macrophages in the early stages of infection?
T cells
What results in the clonal expansion of T cells?
Interleukin 2 (IL-2)
Where do effector CD4+ cells and Effector CD8+ cells or CTLs migrate to?
Site of the infection
In what order do the phases of T cell responses occur?
Recognition, Clonal Expansion, Differentiation, Migration
Where do the complementary determining regions (CDRs) occur on the B cell receptor (BCR)?
Antigen-binding variable region
What is the effector region of a secreted immunoglobulin such as IgG?
Fc region
What initiates cell killing by binding to cell surface receptors?
Fc region
What does receptor editing in developing B cells involve?
Reactivation of the RAG genes
Where do B cells expressing IgM and IgD migrate to respond to their specific antigen?
Peripheral lymphoid tissues
What phosphorylates the CD3 and zeta chains in T cell signal transduction?
Tyrosine residues
What is an example of autocrine stimulation in immune cells?
IL-2 binding to IL-2 receptor
What kind of memory cells are produced 14 days following a viral infection?
Only memory lymphocytes remain
What differentiates Tfh cells from other effector T cells?
Tfh cells migrate into lymphoid follicles
What is the main function of Th2 cells in the immune response?
Response against intestinal worms and allergies
What is unique about the IL-2 receptor on an activated T cell compared to a naïve T cell?
Activated T cells express CD25 chain of the receptor
What is the effect of CD40 ligand binding to CD40 on APCs?
Enhancement of B7 expression by APCs
Which type of cell helps B cells develop into plasma cells that secrete antibodies?
Follicular helper T cells
Test your knowledge on eculizumab, its interaction with C5, challenges posed by Rickettsia for the immune system, and the coordination of macrophages and helper T cells in fighting infections. Explore the chronological order of T cell response phases.
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