Questions and Answers
What occurs mostly in the fallopian tube and migrates to the uterus during development?
Fertilization
What is the result of rapid synchronized cell division without growth during zygote development?
Cleavage to give morula
What is the function of the zona pellucida during fertilization?
Acts as a container for early development
What is the characteristic of cells at the morula stage?
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What is the mid-blastula transition?
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What facilitates the re-gain of mitotic checkpoints during embryonic development?
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At what stage does the selection for euploid cells begin during natural fertilization?
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Why is IVF success to live birth about 2 fold more successful using blastocyst stage than morula stage?
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What is the main function of trophoblasts during embryonic development?
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What marks the beginning of the formation of the placenta during embryonic development?
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What is the function of the bilaminar disc during embryonic development?
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What is the result of invagination/migration of epiblast cells at the primitive streak/node during embryonic development?
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Study Notes
Fertilization and Embryonic Development
- Embryos mostly develop in the fallopian tube and migrate to the uterus during development.
Zygote Development
- Rapid synchronized cell division without growth during zygote development results in cleavage.
Fertilization Mechanisms
- The zona pellucida functions to prevent polyspermy during fertilization.
Morula Stage
- Cells at the morula stage are compacted, forming a tight cluster of cells.
Mid-Blastula Transition
- The mid-blastula transition is a brief period of embryonic development characterized by a transition from maternal to zygotic control.
Embryonic Development Checkpoints
- The re-gain of mitotic checkpoints during embryonic development is facilitated by the activation of the zygotic genome.
Natural Fertilization
- Selection for euploid cells begins during natural fertilization at the cleavage stage.
IVF Success
- IVF success to live birth is approximately 2-fold more successful using blastocyst stage than morula stage due to the increased selection of euploid cells.
Trophoblasts
- The main function of trophoblasts during embryonic development is to promote implantation and establish the placenta.
Placenta Formation
- The formation of the placenta during embryonic development begins with the differentiation of trophoblasts.
Bilaminar Disc
- The bilaminar disc functions to establish the embryonic and abembryonic poles of the embryo.
Primitive Streak/Node
- The invagination/migration of epiblast cells at the primitive streak/node results in the formation of the germ layers.
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