Drug Distribution in Organic Systems Quiz

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A drug must pass through many barriers, survive alternate sites of attachment and storage, and avoid significant metabolic destruction before it reaches the site of action.

True

Drugs administered orally always remain in solution as they pass through the gastrointestinal tract.

False

The ability of a drug to dissolve is only influenced by its chemical structure.

False

Varying the dosage form and physical characteristics of a drug has no impact on its dissolution rate.

False Signup and view all the answers

Chemical modification is commonly used to facilitate a drug reaching its desired target.

False Signup and view all the answers

For oral administration, drugs need to go into solution to pass through the gastrointestinal mucosa.

True Signup and view all the answers

Subcutaneous and intramuscular injections show rapid distribution of the drug.

False Signup and view all the answers

Intravenous administration places the drug directly into the gastrointestinal tract.

False Signup and view all the answers

Parenteral dosage forms are used to bypass the intestinal barrier.

True Signup and view all the answers

Olsalazine is more effective orally than mesalamine.

False Signup and view all the answers

Intravenous administration leads to slow distribution of the drug throughout the body.

False Signup and view all the answers

Chloramphenicol is water insoluble.

False Signup and view all the answers

Oral administration is always preferred over parenteral administration.

False Signup and view all the answers

Drugs administered orally may face obstacles like first-pass effect in the liver.

True Signup and view all the answers

The dimeric form of olsalazine is cleaved by intestinal bacteria to two equivalents of mesalamine.

True Signup and view all the answers

If a drug molecule cannot survive in the intestinal tract, it will likely be considered for alternate routes such as parenteral, buccal, or transdermal administration.

True Signup and view all the answers

The effectiveness of a new drug can only be enhanced if it can be administered through alternate routes.

False Signup and view all the answers

Chloramphenicol interacts with taste receptors on the tongue to produce a sweet taste.

False Signup and view all the answers

Protein binding can impact the effective solubility of a drug.

True Signup and view all the answers

Protein binding has no effect on drug's biodistribution.

False Signup and view all the answers

The drug-albumin complex can pass through renal glomerular membranes easily.

False Signup and view all the answers

The half-life of a drug can be affected by protein binding.

True Signup and view all the answers

Proteins in the maternal circulation can't protect the fetus from harmful drugs.

False Signup and view all the answers

A drug with poor water solubility can still be effective due to protein binding.

True Signup and view all the answers

Methylprednisolone sodium succinate is a water-soluble sodium salt of acetate ester.

False Signup and view all the answers

Etretinate has a terminal half-life of 33-96 hours.

False Signup and view all the answers

Acitretin is recommended for a woman who would like to become pregnant due to its longer half-life.

False Signup and view all the answers

Protein binding occurs when drugs bind to serum proteins like hemoglobin.

False Signup and view all the answers

Esterases are responsible for hydrolyzing succinate esters to active methylprednisolone.

True Signup and view all the answers

Acitretin and etretinate are both drugs used to treat psoriasis but are not teratogenic.

False Signup and view all the answers

Chloramphenicol palmitate is an example of a prodrug.

True Signup and view all the answers

Enalaprilic acid is more effectively absorbed orally than enalapril.

False Signup and view all the answers

Most prodrugs are active in their native form and do not need to be metabolized to the active agent.

False Signup and view all the answers

Olsalazine is cleaved by digestive esterases to the active drug mesalamine.

False Signup and view all the answers

The primary function of ester prodrugs like chloramphenicol palmitate is to increase water solubility.

False Signup and view all the answers

Drugs intended to act locally in the gastrointestinal tract must pass through the gastrointestinal mucosal barrier to reach the site of action.

True Signup and view all the answers

Subcutaneous injections result in rapid distribution of the drug due to immediate entry into the circulatory system.

False Signup and view all the answers

Drugs administered orally can face first-pass effect in the liver, leading to rapid metabolism before reaching systemic circulation.

True Signup and view all the answers

Intravenous administration bypasses the intestinal barrier and ensures slow distribution of the drug throughout the body.

False Signup and view all the answers

Parenteral dosage forms are advantageous for patients who cannot accept drugs orally due to illness or incapability.

True Signup and view all the answers

Proteins in the maternal circulation can shield the fetus from harmful drugs due to their protective properties.

False Signup and view all the answers

Intramuscular injections lead to immediate diffusion of the drug into systemic circulation, ensuring rapid distribution throughout the body.

False Signup and view all the answers

Protein binding can limit the amount of drug available for interaction with specific receptor sites.

True Signup and view all the answers

The drug suramin has a short half-life of 3 days in the body.

False Signup and view all the answers

Drug-protein binding interactions cannot lead to clinically significant drug-drug interactions.

False Signup and view all the answers

Tissue depots for drug storage are primarily composed of water.

False Signup and view all the answers

The more lipophilic a drug is, the less likely it will concentrate in tissue depots.

False Signup and view all the answers

Drug biodistribution is not impacted by protein binding.

False Signup and view all the answers

Protein binding does not affect the drug's biodistribution.

False Signup and view all the answers

A drug with poor water solubility cannot be effective due to protein binding.

False Signup and view all the answers

Protein binding impacts the drug's half-life in the body and duration of action.

True Signup and view all the answers

Drugs that would normally pass the placental barrier are retained in maternal circulation due to protein binding.

True Signup and view all the answers

The drug-albumin complex passes easily through renal glomerular membranes.

False Signup and view all the answers

Modifying the chemical structure of a drug has no impact on its dissolution rate.

False Signup and view all the answers

Barbiturates with polar side chains have a shorter duration of action than those with lipophilic side chains.

True Signup and view all the answers

Thiopental diffuses out of tissue depots into systemic circulation in concentrations high enough for a pharmacological response.

False Signup and view all the answers

Barbiturates with slow onset of action contain more lipophilic side chains compared to those with fast onset of action.

False Signup and view all the answers

Thiopental is metabolized primarily in the kidneys before being excreted from the body.

False Signup and view all the answers

Barbiturates that enter and leave the central nervous system slowly have lipophilic side chains.

False Signup and view all the answers

Structural changes favoring partitioning into lipid stores result in an increased duration of action but decreased CNS depression.

False Signup and view all the answers

Drug Distribution in Organic Systems Quiz

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Questions and Answers

A drug must pass through many barriers, survive alternate sites of attachment and storage, and avoid significant metabolic destruction before it reaches the site of action.

Drugs administered orally always remain in solution as they pass through the gastrointestinal tract.

The ability of a drug to dissolve is only influenced by its chemical structure.

Varying the dosage form and physical characteristics of a drug has no impact on its dissolution rate.

Chemical modification is commonly used to facilitate a drug reaching its desired target.

For oral administration, drugs need to go into solution to pass through the gastrointestinal mucosa.

Subcutaneous and intramuscular injections show rapid distribution of the drug.

Intravenous administration places the drug directly into the gastrointestinal tract.

Parenteral dosage forms are used to bypass the intestinal barrier.

Olsalazine is more effective orally than mesalamine.

Intravenous administration leads to slow distribution of the drug throughout the body.

Chloramphenicol is water insoluble.

Oral administration is always preferred over parenteral administration.

Drugs administered orally may face obstacles like first-pass effect in the liver.

The dimeric form of olsalazine is cleaved by intestinal bacteria to two equivalents of mesalamine.

If a drug molecule cannot survive in the intestinal tract, it will likely be considered for alternate routes such as parenteral, buccal, or transdermal administration.

The effectiveness of a new drug can only be enhanced if it can be administered through alternate routes.

Chloramphenicol interacts with taste receptors on the tongue to produce a sweet taste.

Protein binding can impact the effective solubility of a drug.

Protein binding has no effect on drug's biodistribution.

The drug-albumin complex can pass through renal glomerular membranes easily.

The half-life of a drug can be affected by protein binding.

Proteins in the maternal circulation can't protect the fetus from harmful drugs.

A drug with poor water solubility can still be effective due to protein binding.

Methylprednisolone sodium succinate is a water-soluble sodium salt of acetate ester.

Etretinate has a terminal half-life of 33-96 hours.

Acitretin is recommended for a woman who would like to become pregnant due to its longer half-life.

Protein binding occurs when drugs bind to serum proteins like hemoglobin.

Esterases are responsible for hydrolyzing succinate esters to active methylprednisolone.

Acitretin and etretinate are both drugs used to treat psoriasis but are not teratogenic.

Chloramphenicol palmitate is an example of a prodrug.

Enalaprilic acid is more effectively absorbed orally than enalapril.

Most prodrugs are active in their native form and do not need to be metabolized to the active agent.

Olsalazine is cleaved by digestive esterases to the active drug mesalamine.

The primary function of ester prodrugs like chloramphenicol palmitate is to increase water solubility.

Drugs intended to act locally in the gastrointestinal tract must pass through the gastrointestinal mucosal barrier to reach the site of action.

Subcutaneous injections result in rapid distribution of the drug due to immediate entry into the circulatory system.

Drugs administered orally can face first-pass effect in the liver, leading to rapid metabolism before reaching systemic circulation.

Intravenous administration bypasses the intestinal barrier and ensures slow distribution of the drug throughout the body.

Parenteral dosage forms are advantageous for patients who cannot accept drugs orally due to illness or incapability.

Proteins in the maternal circulation can shield the fetus from harmful drugs due to their protective properties.

Intramuscular injections lead to immediate diffusion of the drug into systemic circulation, ensuring rapid distribution throughout the body.

Protein binding can limit the amount of drug available for interaction with specific receptor sites.

The drug suramin has a short half-life of 3 days in the body.

Drug-protein binding interactions cannot lead to clinically significant drug-drug interactions.

Tissue depots for drug storage are primarily composed of water.

The more lipophilic a drug is, the less likely it will concentrate in tissue depots.

Drug biodistribution is not impacted by protein binding.

Protein binding does not affect the drug's biodistribution.

A drug with poor water solubility cannot be effective due to protein binding.

Protein binding impacts the drug's half-life in the body and duration of action.

Drugs that would normally pass the placental barrier are retained in maternal circulation due to protein binding.

The drug-albumin complex passes easily through renal glomerular membranes.

Modifying the chemical structure of a drug has no impact on its dissolution rate.

Barbiturates with polar side chains have a shorter duration of action than those with lipophilic side chains.

Thiopental diffuses out of tissue depots into systemic circulation in concentrations high enough for a pharmacological response.

Barbiturates with slow onset of action contain more lipophilic side chains compared to those with fast onset of action.

Thiopental is metabolized primarily in the kidneys before being excreted from the body.

Barbiturates that enter and leave the central nervous system slowly have lipophilic side chains.

Structural changes favoring partitioning into lipid stores result in an increased duration of action but decreased CNS depression.

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