Questions and Answers
Which of the following factors affects drug distribution?
Blood flow (perfusion)
What is the volume of distribution (Vd)?
The extent to which a drug is distributed throughout the body
What factors can affect the volume of distribution?
Plasma protein binding
What is the process called when a drug moves from the bloodstream to different organs and tissues?
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Which of the following affects the rate of drug distribution?
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Study Notes
Factors Affecting Drug Distribution
- Multiple factors can affect drug distribution, including various patient- and drug-related factors.
Volume of Distribution (Vd)
- The volume of distribution (Vd) is a pharmacokinetic parameter that refers to the apparent volume in which a drug is dissolved in the body.
- It is a measure of the extent of drug distribution.
Factors Affecting Volume of Distribution
- The volume of distribution can be affected by factors such as:
- Binding to plasma proteins and tissues
- Lipid solubility of the drug
- pH-dependent ionization of the drug
- Blood flow to the organs and tissues
- Permeability of membranes
Process of Drug Distribution
- The process of a drug moving from the bloodstream to different organs and tissues is called distribution.
Rate of Drug Distribution
- The rate of drug distribution can be affected by factors such as:
- Blood flow to the organs and tissues
- Permeability of membranes
- Lipid solubility of the drug
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