Podcast
Questions and Answers
What is the main result of DNA mutation?
What is the main result of DNA mutation?
- Inhibition of DNA replication
- Change in the tRNA structure
- Increase in protein synthesis
- Change in the mRNA codon nucleotide sequence (correct)
Which type of mutation arises when a base pair with an inappropriate partner during DNA replication?
Which type of mutation arises when a base pair with an inappropriate partner during DNA replication?
- Frameshift Mutation
- Point Mutation (correct)
- Nonsense Mutation
- Silent Mutation
What is the result of a nonsense mutation?
What is the result of a nonsense mutation?
- Increase in protein synthesis
- Creation of new proteins
- Change in the RNA nucleotide sequence
- Change in the protein being translated into (correct)
In a transition type of point mutation, what occurs?
In a transition type of point mutation, what occurs?
What is the clinical significance of a nonsense mutation?
What is the clinical significance of a nonsense mutation?
What does a missense mutation change?
What does a missense mutation change?
What are the two general classes of DNA repair discussed in the text?
What are the two general classes of DNA repair discussed in the text?
Which type of DNA damage can be repaired by photoreactivation?
Which type of DNA damage can be repaired by photoreactivation?
What is the name of the enzyme involved in photoreactivation?
What is the name of the enzyme involved in photoreactivation?
Which DNA repair mechanism requires light for its function?
Which DNA repair mechanism requires light for its function?
What is the function of the protein MGMT in DNA repair?
What is the function of the protein MGMT in DNA repair?
Which type of DNA damage can be reversed by O6methylguanine methyltransferase?
Which type of DNA damage can be reversed by O6methylguanine methyltransferase?
What is the consequence of a point mutation in the B-globin chain of Hemoglobin causing codon GAG to change into GUG?
What is the consequence of a point mutation in the B-globin chain of Hemoglobin causing codon GAG to change into GUG?
Which type of mutation refers to the loss of a single base either spontaneously or due to damage?
Which type of mutation refers to the loss of a single base either spontaneously or due to damage?
When can frameshift mutations likely occur?
When can frameshift mutations likely occur?
What causes DNA damage leading to mutation and genomic instability?
What causes DNA damage leading to mutation and genomic instability?
Which process can identify the correct damage in DNA molecules for repair?
Which process can identify the correct damage in DNA molecules for repair?
What does DNA encode, making it a permanent copy necessary for cell functioning?
What does DNA encode, making it a permanent copy necessary for cell functioning?
What is the term used to describe an enzyme that becomes inactivated after accepting an alkyl group through its sulfur atom of a cysteine residue?
What is the term used to describe an enzyme that becomes inactivated after accepting an alkyl group through its sulfur atom of a cysteine residue?
Which type of repair involves the removal of a single damaged base and requires glycosylases enzymes?
Which type of repair involves the removal of a single damaged base and requires glycosylases enzymes?
What is the general mechanism by which repairs are made when one of the double helix strands is damaged?
What is the general mechanism by which repairs are made when one of the double helix strands is damaged?
What occurs after the damaged DNA on one strand is removed in the excision repair process?
What occurs after the damaged DNA on one strand is removed in the excision repair process?
Which repair mechanism involves recognizing damage and cleaving it on both sides by endonucleases before resynthesis by DNA polymerase?
Which repair mechanism involves recognizing damage and cleaving it on both sides by endonucleases before resynthesis by DNA polymerase?
What kind of damage does Nucleotide Excision Repair specifically recognize for repairs?
What kind of damage does Nucleotide Excision Repair specifically recognize for repairs?
What is the main function of mismatch repair in DNA replication?
What is the main function of mismatch repair in DNA replication?
Which repair mechanism is particularly important in maintaining genomic integrity by fixing damage to both DNA strands?
Which repair mechanism is particularly important in maintaining genomic integrity by fixing damage to both DNA strands?
What is one of the risks associated with single-stranded annealing and alternative joining as repair mechanisms?
What is one of the risks associated with single-stranded annealing and alternative joining as repair mechanisms?
Which repair mechanism connects double strand break ends without using a homologous template?
Which repair mechanism connects double strand break ends without using a homologous template?
What is the undefined mechanism used in repairing double strand breaks that risks genomic integrity?
What is the undefined mechanism used in repairing double strand breaks that risks genomic integrity?
How does homologous recombination repair damaged bases on both strands of DNA?
How does homologous recombination repair damaged bases on both strands of DNA?
