DNA Repair Mechanisms Quiz

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Questions and Answers

Which process directly reverses pyrimidine dimers caused by UV light?

  • Excision repair
  • Photoreactivation (correct)
  • Methylation of guanine bases
  • Methyl guanine methyl transferase (MGMT)

What is the bacterial equivalent enzyme for the protein methyl guanine methyl transferase (MGMT)?

  • Excision repair
  • Methylation of guanine bases
  • Photoreactivation
  • Methyl guanine methyl transferase (MGMT) (correct)

Which DNA repair mechanism does not require a template and does not involve the breakage of the phosphodiester backbone?

  • Photoreactivation
  • Excision repair
  • Direct reversal mechanisms (correct)
  • Methylation of guanine bases

What type of DNA damage does UV-B light cause?

<p>Formation of pyrimidine dimers (A)</p> Signup and view all the answers

How is the damage caused by UV-A light referred to?

<p>Indirect DNA damage (A)</p> Signup and view all the answers

Which type of DNA damage can be reversed by photoreactivation?

<p>Formation of pyrimidine dimers by UV-B light (D)</p> Signup and view all the answers

What may low-level ionizing radiation induce?

<p>Replicational and transcriptional errors (A)</p> Signup and view all the answers

Which repair mechanism is responsible for correcting errors of DNA replication and recombination?

<p>Mismatch repair (MMR) (C)</p> Signup and view all the answers

What is the major pathway for repair of modified bases, uracil misincorporation, oxidation, alkylation, hydrolysis, or deamination damage?

<p>Base excision repair (BER) (A)</p> Signup and view all the answers

Which repair mechanism recognizes bulky lesions that block DNA replication?

<p>Nucleotide excision repair (NER) (C)</p> Signup and view all the answers

What is the outcome of the action of DNA glycosylases during base excision repair?

<p>Creation of an abasic site (A)</p> Signup and view all the answers

What can cause DNA damage in human cells?

<p>Normal metabolic activities and UV light (D)</p> Signup and view all the answers

What is the consequence of DNA repair process being constantly active?

<p>Prevention of harmful mutations in the cell's genome (A)</p> Signup and view all the answers

What can a cell with a large amount of DNA damage or ineffective repair enter into?

<p>Senescence, apoptosis, or unregulated cell division (B)</p> Signup and view all the answers

Which of the following is an example of exogenous DNA damage?

<p>Radiations and chemicals (C)</p> Signup and view all the answers

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