15 Questions
Which process directly reverses pyrimidine dimers caused by UV light?
Photoreactivation
What is the bacterial equivalent enzyme for the protein methyl guanine methyl transferase (MGMT)?
Methyl guanine methyl transferase (MGMT)
Which DNA repair mechanism does not require a template and does not involve the breakage of the phosphodiester backbone?
Direct reversal mechanisms
What type of DNA damage does UV-B light cause?
Formation of pyrimidine dimers
How is the damage caused by UV-A light referred to?
Indirect DNA damage
Which type of DNA damage can be reversed by photoreactivation?
Formation of pyrimidine dimers by UV-B light
What may low-level ionizing radiation induce?
Replicational and transcriptional errors
Which repair mechanism is responsible for correcting errors of DNA replication and recombination?
Mismatch repair (MMR)
What is the major pathway for repair of modified bases, uracil misincorporation, oxidation, alkylation, hydrolysis, or deamination damage?
Base excision repair (BER)
Which repair mechanism recognizes bulky lesions that block DNA replication?
Nucleotide excision repair (NER)
What is the outcome of the action of DNA glycosylases during base excision repair?
Creation of an abasic site
What can cause DNA damage in human cells?
Normal metabolic activities and UV light
What is the consequence of DNA repair process being constantly active?
Prevention of harmful mutations in the cell's genome
What can a cell with a large amount of DNA damage or ineffective repair enter into?
Senescence, apoptosis, or unregulated cell division
Which of the following is an example of exogenous DNA damage?
Radiations and chemicals
Test your knowledge of DNA repair mechanisms with this quiz. Explore topics like direct reversal mechanisms and their role in preventing translation and DNA replication.
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