DNA Repair Mechanisms Quiz
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Questions and Answers

Which process directly reverses pyrimidine dimers caused by UV light?

  • Excision repair
  • Photoreactivation (correct)
  • Methylation of guanine bases
  • Methyl guanine methyl transferase (MGMT)
  • What is the bacterial equivalent enzyme for the protein methyl guanine methyl transferase (MGMT)?

  • Excision repair
  • Methylation of guanine bases
  • Photoreactivation
  • Methyl guanine methyl transferase (MGMT) (correct)
  • Which DNA repair mechanism does not require a template and does not involve the breakage of the phosphodiester backbone?

  • Photoreactivation
  • Excision repair
  • Direct reversal mechanisms (correct)
  • Methylation of guanine bases
  • What type of DNA damage does UV-B light cause?

    <p>Formation of pyrimidine dimers</p> Signup and view all the answers

    How is the damage caused by UV-A light referred to?

    <p>Indirect DNA damage</p> Signup and view all the answers

    Which type of DNA damage can be reversed by photoreactivation?

    <p>Formation of pyrimidine dimers by UV-B light</p> Signup and view all the answers

    What may low-level ionizing radiation induce?

    <p>Replicational and transcriptional errors</p> Signup and view all the answers

    Which repair mechanism is responsible for correcting errors of DNA replication and recombination?

    <p>Mismatch repair (MMR)</p> Signup and view all the answers

    What is the major pathway for repair of modified bases, uracil misincorporation, oxidation, alkylation, hydrolysis, or deamination damage?

    <p>Base excision repair (BER)</p> Signup and view all the answers

    Which repair mechanism recognizes bulky lesions that block DNA replication?

    <p>Nucleotide excision repair (NER)</p> Signup and view all the answers

    What is the outcome of the action of DNA glycosylases during base excision repair?

    <p>Creation of an abasic site</p> Signup and view all the answers

    What can cause DNA damage in human cells?

    <p>Normal metabolic activities and UV light</p> Signup and view all the answers

    What is the consequence of DNA repair process being constantly active?

    <p>Prevention of harmful mutations in the cell's genome</p> Signup and view all the answers

    What can a cell with a large amount of DNA damage or ineffective repair enter into?

    <p>Senescence, apoptosis, or unregulated cell division</p> Signup and view all the answers

    Which of the following is an example of exogenous DNA damage?

    <p>Radiations and chemicals</p> Signup and view all the answers

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