Pharm EXAM 2
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Questions and Answers

Which direct adrenergic agonist is known to have a mixed agonist action and is rapidly inactivated?

  • Norepinephrine
  • Dopamine
  • Phenylephrine
  • Epinephrine (correct)
  • What are the ocular toxic side effects associated with topical application of epinephrine?

  • Madarosis (correct)
  • Iris color changes
  • Corneal scarring
  • Retinal detachment
  • Which direct adrenergic agonist is structurally similar to epinephrine and predominantly an alpha 1 agonist?

  • Norepinephrine
  • Epinephrine
  • Dopamine
  • Phenylephrine (correct)
  • What is the main clinical use of Phenylephrine at a 10% concentration?

    <p>Partial dilation</p> Signup and view all the answers

    Which effect is NOT associated with the use of Epinephrine?

    <p>Pupillary constriction</p> Signup and view all the answers

    Which symptom is a potential side effect of Phenylephrine use at a 0.125% concentration?

    <p>Horner's ptosis</p> Signup and view all the answers

    Why are direct adrenergic agonists like Epinephrine not recommended for patients with narrow angles?

    <p>Increased risk of angle closure glaucoma</p> Signup and view all the answers

    'Mueller's and conjunctival arterioles' dilation is associated with which direct adrenergic agonist?

    <p>Phenylephrine</p> Signup and view all the answers

    Which ocular side effect is specifically associated with chronic use of the drug mentioned in the text?

    <p>Decrease in conjunctival/iris PO2</p> Signup and view all the answers

    What systemic side effect is reported in some cases after using the drug mentioned?

    <p>Episodes of rise in blood pressure</p> Signup and view all the answers

    Which drug interaction is NOT mentioned in relation to the drug discussed?

    <p>Dopamine agonists</p> Signup and view all the answers

    What is a contraindication for the drug mentioned in the text?

    <p>Malignant hypertension</p> Signup and view all the answers

    Which indirect adrenergic agonist works by liberating norepinephrine from the presynaptic vesicle at the neuromuscular junction?

    <p>Hydroxyamphetamine (paredrine)</p> Signup and view all the answers

    What is a clinical use of Paremyd which contains a combination of 1% hydroxyamphetamine and .25% tropicamide?

    <p>Inducing complete pupil dilation</p> Signup and view all the answers

    Which symptom helps differentiate between central/2nd neuron and 3rd neuron Horner’s syndrome when treated with certain drugs mentioned?

    <p><strong>Moderate irritation</strong></p> Signup and view all the answers

    What is the anesthetic action of cocaine when used in ophthalmic solutions?

    <p><strong>Blocking reuptake of norepinephrine</strong></p> Signup and view all the answers

    Where are M4 receptors predominantly found?

    <p>Basal ganglia</p> Signup and view all the answers

    Which receptor type is found in the substantia nigra in the midbrain?

    <p>M5</p> Signup and view all the answers

    What is the primary effect of M2 receptor stimulation in the heart?

    <p>Decrease heart rate</p> Signup and view all the answers

    Which neurotransmitter signal transduction occurs through activation of a 2nd messenger leading to increased intracellular [Ca]?

    <p>Acetylcholine</p> Signup and view all the answers

    Why is acetylcholine of no importance therapeutically?

    <p>Rapid inactivation</p> Signup and view all the answers

    Which drug is structurally related to acetylcholine but not destroyed by acetylcholinesterase?

    <p>Bethanechol</p> Signup and view all the answers

    What is the primary action of bethanechol?

    <p>Increased bladder tone</p> Signup and view all the answers

    What is the main factor that sets bethanechol apart from acetylcholine?

    <p>Rapid inactivation by acetylcholinesterase</p> Signup and view all the answers

    Which medication is an irreversible acetylcholinesterase inhibitor used as an insecticide?

    <p>Echothiophate</p> Signup and view all the answers

    Which of the following medications is used in the treatment of Alzheimer's disease?

    <p>Rivastigmine</p> Signup and view all the answers

    What is the main use of Neostigmine in the context of myasthenia gravis?

    <p>Treatment of skeletal muscle weakness</p> Signup and view all the answers

    Which medication is used intravenously for the diagnosis of myasthenia gravis?

    <p>Edrophonium</p> Signup and view all the answers

    What are the side effects associated with muscarinic agonists?

    <p>Diarrhea, diaphoresis, miosis, nausea</p> Signup and view all the answers

    Which medication is derived from the belladonna alkaloid and has antimuscarinic effects?

    <p>Atropine</p> Signup and view all the answers

    Which medication is used as an antidote for tubocurarine and neuromuscular blockers?

    <p>Pyridostigmine</p> Signup and view all the answers

    What is the therapeutic use of Echothiophate?

    <p>Chronic treatment of open angle glaucoma.</p> Signup and view all the answers

    What is the mechanism of action of theophylline and aminophylline?

    <p>Phosphodiesterase inhibition causing an increase in cAMP</p> Signup and view all the answers

    Which enzyme metabolizes theophylline?

    <p>Cyt P450 enzymes</p> Signup and view all the answers

    What is the primary side effect associated with theophylline and aminophylline?

    <p>Hypotension</p> Signup and view all the answers

    Which type of drugs are glucocorticoids in asthma management?

    <p>Anti-inflammatory agents</p> Signup and view all the answers

    What is the primary function of maintenance therapy drugs in asthma management?

    <p>Reduce inflammatory cells in the airways</p> Signup and view all the answers

    Why are glucocorticoids given as prophylactic medications in asthma?

    <p>To reduce bronchial inflammation</p> Signup and view all the answers

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