Pharm EXAM 2

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Questions and Answers

Which direct adrenergic agonist is known to have a mixed agonist action and is rapidly inactivated?

  • Norepinephrine
  • Dopamine
  • Phenylephrine
  • Epinephrine (correct)

What are the ocular toxic side effects associated with topical application of epinephrine?

  • Madarosis (correct)
  • Iris color changes
  • Corneal scarring
  • Retinal detachment

Which direct adrenergic agonist is structurally similar to epinephrine and predominantly an alpha 1 agonist?

  • Norepinephrine
  • Epinephrine
  • Dopamine
  • Phenylephrine (correct)

What is the main clinical use of Phenylephrine at a 10% concentration?

<p>Partial dilation (B)</p> Signup and view all the answers

Which effect is NOT associated with the use of Epinephrine?

<p>Pupillary constriction (A)</p> Signup and view all the answers

Which symptom is a potential side effect of Phenylephrine use at a 0.125% concentration?

<p>Horner's ptosis (D)</p> Signup and view all the answers

Why are direct adrenergic agonists like Epinephrine not recommended for patients with narrow angles?

<p>Increased risk of angle closure glaucoma (A)</p> Signup and view all the answers

'Mueller's and conjunctival arterioles' dilation is associated with which direct adrenergic agonist?

<p>Phenylephrine (C)</p> Signup and view all the answers

Which ocular side effect is specifically associated with chronic use of the drug mentioned in the text?

<p>Decrease in conjunctival/iris PO2 (B)</p> Signup and view all the answers

What systemic side effect is reported in some cases after using the drug mentioned?

<p>Episodes of rise in blood pressure (D)</p> Signup and view all the answers

Which drug interaction is NOT mentioned in relation to the drug discussed?

<p>Dopamine agonists (C)</p> Signup and view all the answers

What is a contraindication for the drug mentioned in the text?

<p>Malignant hypertension (A)</p> Signup and view all the answers

Which indirect adrenergic agonist works by liberating norepinephrine from the presynaptic vesicle at the neuromuscular junction?

<p>Hydroxyamphetamine (paredrine) (C)</p> Signup and view all the answers

What is a clinical use of Paremyd which contains a combination of 1% hydroxyamphetamine and .25% tropicamide?

<p>Inducing complete pupil dilation (A)</p> Signup and view all the answers

Which symptom helps differentiate between central/2nd neuron and 3rd neuron Horner’s syndrome when treated with certain drugs mentioned?

<p><strong>Moderate irritation</strong> (B)</p> Signup and view all the answers

What is the anesthetic action of cocaine when used in ophthalmic solutions?

<p><strong>Blocking reuptake of norepinephrine</strong> (C)</p> Signup and view all the answers

Where are M4 receptors predominantly found?

<p>Basal ganglia (C)</p> Signup and view all the answers

Which receptor type is found in the substantia nigra in the midbrain?

<p>M5 (D)</p> Signup and view all the answers

What is the primary effect of M2 receptor stimulation in the heart?

<p>Decrease heart rate (B)</p> Signup and view all the answers

Which neurotransmitter signal transduction occurs through activation of a 2nd messenger leading to increased intracellular [Ca]?

<p>Acetylcholine (B)</p> Signup and view all the answers

Why is acetylcholine of no importance therapeutically?

<p>Rapid inactivation (A)</p> Signup and view all the answers

Which drug is structurally related to acetylcholine but not destroyed by acetylcholinesterase?

<p>Bethanechol (A)</p> Signup and view all the answers

What is the primary action of bethanechol?

<p>Increased bladder tone (C)</p> Signup and view all the answers

What is the main factor that sets bethanechol apart from acetylcholine?

<p>Rapid inactivation by acetylcholinesterase (D)</p> Signup and view all the answers

Which medication is an irreversible acetylcholinesterase inhibitor used as an insecticide?

<p>Echothiophate (D)</p> Signup and view all the answers

Which of the following medications is used in the treatment of Alzheimer's disease?

<p>Rivastigmine (D)</p> Signup and view all the answers

What is the main use of Neostigmine in the context of myasthenia gravis?

<p>Treatment of skeletal muscle weakness (A)</p> Signup and view all the answers

Which medication is used intravenously for the diagnosis of myasthenia gravis?

<p>Edrophonium (D)</p> Signup and view all the answers

What are the side effects associated with muscarinic agonists?

<p>Diarrhea, diaphoresis, miosis, nausea (A)</p> Signup and view all the answers

Which medication is derived from the belladonna alkaloid and has antimuscarinic effects?

<p>Atropine (D)</p> Signup and view all the answers

Which medication is used as an antidote for tubocurarine and neuromuscular blockers?

<p>Pyridostigmine (D)</p> Signup and view all the answers

What is the therapeutic use of Echothiophate?

<p>Chronic treatment of open angle glaucoma. (B)</p> Signup and view all the answers

What is the mechanism of action of theophylline and aminophylline?

<p>Phosphodiesterase inhibition causing an increase in cAMP (D)</p> Signup and view all the answers

Which enzyme metabolizes theophylline?

<p>Cyt P450 enzymes (A)</p> Signup and view all the answers

What is the primary side effect associated with theophylline and aminophylline?

<p>Hypotension (A)</p> Signup and view all the answers

Which type of drugs are glucocorticoids in asthma management?

<p>Anti-inflammatory agents (D)</p> Signup and view all the answers

What is the primary function of maintenance therapy drugs in asthma management?

<p>Reduce inflammatory cells in the airways (C)</p> Signup and view all the answers

Why are glucocorticoids given as prophylactic medications in asthma?

<p>To reduce bronchial inflammation (B)</p> Signup and view all the answers

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