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Questions and Answers
What is the primary mechanism of action of direct acting selective sympathomimetic drugs?
What is the primary mechanism of action of direct acting selective sympathomimetic drugs?
Which of the following is a clinical use of direct acting selective sympathomimetic drugs?
Which of the following is a clinical use of direct acting selective sympathomimetic drugs?
What is a common side effect of direct acting selective sympathomimetic drugs?
What is a common side effect of direct acting selective sympathomimetic drugs?
Which of the following is an example of a direct acting selective sympathomimetic drug?
Which of the following is an example of a direct acting selective sympathomimetic drug?
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What is the primary advantage of using direct acting selective sympathomimetic drugs over non-selective sympathomimetic drugs?
What is the primary advantage of using direct acting selective sympathomimetic drugs over non-selective sympathomimetic drugs?
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What is the primary outcome of direct stimulation of β2 receptors in the lungs by direct acting selective sympathomimetic drugs?
What is the primary outcome of direct stimulation of β2 receptors in the lungs by direct acting selective sympathomimetic drugs?
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Which of the following conditions is NOT a therapeutic indication for direct acting selective sympathomimetic drugs?
Which of the following conditions is NOT a therapeutic indication for direct acting selective sympathomimetic drugs?
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What is the primary reason for the lower incidence of cardiovascular side effects associated with direct acting selective sympathomimetic drugs?
What is the primary reason for the lower incidence of cardiovascular side effects associated with direct acting selective sympathomimetic drugs?
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What is the typical duration of action of direct acting selective sympathomimetic drugs?
What is the typical duration of action of direct acting selective sympathomimetic drugs?
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What is the primary route of administration for direct acting selective sympathomimetic drugs?
What is the primary route of administration for direct acting selective sympathomimetic drugs?
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What is the primary mechanism of elimination for direct acting selective sympathomimetic drugs?
What is the primary mechanism of elimination for direct acting selective sympathomimetic drugs?
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Study Notes
Direct Acting Selective Sympathomimetic Drugs
- Primary mechanism of action: stimulate specific adrenergic receptors, producing specific responses
- Clinical uses: treat conditions such as nasal congestion, asthma, and anaphylaxis
Side Effects
- Common side effect: tachycardia (rapid heart rate)
Examples
- Example of a direct acting selective sympathomimetic drug: salmeterol
Advantages
- Primary advantage over non-selective sympathomimetic drugs: reduced risk of unwanted effects on other organs, leading to increased safety and efficacy
Direct Acting Selective Sympathomimetic Drug
Mechanism of Action
- Directly stimulate β2 receptors in the lungs to relax airway smooth muscle, increase bronchodilation, and improve lung function
- Selectively target β2 receptors, minimizing stimulation of β1 receptors in the heart and reducing cardiovascular side effects
Therapeutic Indications
- Used to treat asthma, chronic obstructive pulmonary disease (COPD), and exercise-induced bronchospasm
Adverse Effects
- Common adverse effects include tremors, nervousness, headache, and palpitations
- Less common adverse effects include hypokalemia (low potassium levels), hyperglycemia (high blood sugar), and paradoxical bronchospasm (rare)
Dosage and Administration
- Administered via inhalation route using a metered-dose inhaler (MDI) or dry powder inhaler (DPI)
- Typical dosage varies depending on the specific drug and patient population, but typically ranges from 2-4 puffs, 2-3 times a day
Pharmacokinetics
- Rapid absorption from the lungs into the bloodstream
- Peak plasma concentrations reached within 10-30 minutes
- Short duration of action, lasting 4-6 hours
- Metabolized by the liver and excreted in the urine
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Description
Explore the primary mechanism of action, clinical uses, side effects, and examples of direct acting selective sympathomimetic drugs. Test your knowledge on the advantages of using these drugs over non-selective sympathomimetic drugs.
