Podcast
Questions and Answers
What is the main reason why catecholamines administered orally are ineffective?
What is the main reason why catecholamines administered orally are ineffective?
- They are quickly metabolized by MAO and COMT. (correct)
- They cause vasoconstriction in blood vessels.
- They cannot cross the blood brain barrier.
- They cause mydriasis.
Which characteristic of noncatecholamines allows them to have longer half-lives compared to catecholamines?
Which characteristic of noncatecholamines allows them to have longer half-lives compared to catecholamines?
- They do not undergo rapid degradation by MAO and COMT. (correct)
- They can cause vasoconstriction in blood vessels.
- They are substrates for COMT.
- They are polar and cannot cross the blood brain barrier.
At low doses, which adrenergic agonist acts primarily on B2 receptors only?
At low doses, which adrenergic agonist acts primarily on B2 receptors only?
- Isoproterenol
- Epinephrine
- Albuterol (correct)
- Dopamine
What is the main adverse effect of alpha-1 receptor activation?
What is the main adverse effect of alpha-1 receptor activation?
What is the clinical significance of activation of alpha-2 receptors in the central nervous system?
What is the clinical significance of activation of alpha-2 receptors in the central nervous system?
What is the primary therapeutic application of B1 agonists?
What is the primary therapeutic application of B1 agonists?
What is a potential adverse effect of B2 receptor activation in the uterus?
What is a potential adverse effect of B2 receptor activation in the uterus?
What effect does activation of dopamine receptors have on renal vasculature?
What effect does activation of dopamine receptors have on renal vasculature?
What is the primary reason why albuterol is considered highly selective when acting at low doses?
What is the primary reason why albuterol is considered highly selective when acting at low doses?
Which receptor activation leads to relief of severe pain?
Which receptor activation leads to relief of severe pain?
What is the primary therapeutic application for activation of B2 receptors in the uterus?
What is the primary therapeutic application for activation of B2 receptors in the uterus?
What can overstimulation of B1 receptors lead to in some cases?
What can overstimulation of B1 receptors lead to in some cases?
Which type of adrenergic agonists work by promotion of norepinephrine release, blockade of norepinephrine reuptake, and inhibition of norepinephrine inactivation?
Which type of adrenergic agonists work by promotion of norepinephrine release, blockade of norepinephrine reuptake, and inhibition of norepinephrine inactivation?
What is the main difference between catecholamines and noncatecholamines?
What is the main difference between catecholamines and noncatecholamines?
Why are catecholamines unable to cross the blood-brain barrier?
Why are catecholamines unable to cross the blood-brain barrier?
Which enzyme quickly metabolizes catecholamines?
Which enzyme quickly metabolizes catecholamines?
What is the defining feature of indirect adrenergic agonists?
What is the defining feature of indirect adrenergic agonists?
What is the chemical structure that characterizes catecholamines?
What is the chemical structure that characterizes catecholamines?
Why do catecholamines have a brief duration of action?
Why do catecholamines have a brief duration of action?
Which class of adrenergic agonists includes dopamine, epinephrine, isoproterenol, and ephedrine?
Which class of adrenergic agonists includes dopamine, epinephrine, isoproterenol, and ephedrine?
What do noncatecholamines have in common?
What do noncatecholamines have in common?
What is the main difference between direct and indirect adrenergic receptor activation?
What is the main difference between direct and indirect adrenergic receptor activation?
What property prevents chatecholamines from being used orally?
What property prevents chatecholamines from being used orally?
Why are chatecholamines unable to act in the central nervous system?
Why are chatecholamines unable to act in the central nervous system?
