Clinical Correlation: Kidney and Liver Failure
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Questions and Answers

Which of the following is NOT a source of ammonia production in the body?

  • Deamination of nucleic acids
  • Bacterial action on urea in the intestine
  • Breakdown of amino acids
  • Metabolism of glutamine in the liver (correct)

In cases of liver cell failure, the level of ammonia in the blood is expected to be:

  • Unchanged as the liver is not involved in ammonia metabolism
  • Increased due to decreased urea production (correct)
  • Decreased due to impaired ammonia metabolism
  • Increased due to increased deamination of amino acids

Which of the following is NOT a fate of ammonia in the body?

  • Conversion to urea and excretion in urine
  • Conversion to amino acids for protein synthesis (correct)
  • Excretion as ammonia in urine
  • Trapping as glutamine in the liver, brain, and kidneys

Which of the following symptoms is NOT associated with hyperammonemia (elevated ammonia levels in the blood)?

<p>Jaundice (D)</p> Signup and view all the answers

In cases of hereditary hyperammonemia, the underlying cause is:

<p>Deficiency in urea cycle enzymes (D)</p> Signup and view all the answers

Which of the following treatments is recommended for hyperammonemia due to kidney failure?

<p>Administration of neomycin to kill intestinal bacteria (D)</p> Signup and view all the answers

Which of the following amino acids does NOT require a specific transferase for its transamination reaction?

<p>Threonine (D)</p> Signup and view all the answers

In which cellular compartments does transamination occur?

<p>Cytoplasm and mitochondria (B)</p> Signup and view all the answers

Which of the following is NOT a clinically important transamination reaction?

<p>Glutamine Synthetase (C)</p> Signup and view all the answers

In which condition would you expect to see a higher elevation of AST (SGOT) compared to ALT (SGPT)?

<p>Myocardial infarction (D)</p> Signup and view all the answers

Which of the following is NOT a function of transamination reactions?

<p>Synthesis of glucose (D)</p> Signup and view all the answers

Which of the following conditions is associated with an increase in plasma aminotransferase levels?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is NOT a factor that regulates glutamate dehydrogenase activity?

<p>Allosteric activation by NADH and FADH2 (D)</p> Signup and view all the answers

Which of the following statements about the urea cycle is correct?

<p>The rate-limiting step is catalyzed by carbamoyl phosphate synthetase-1 (CPS1). (D)</p> Signup and view all the answers

What is the primary fate of urea produced in the urea cycle?

<p>It is excreted in urine by the kidneys. (D)</p> Signup and view all the answers

Which of the following amino acids is classified as both essential and non-essential?

<p>There are no amino acids that are both essential and non-essential. (A)</p> Signup and view all the answers

What is the primary role of the urea cycle in intermediary metabolism?

<p>To convert excess nitrogen from amino acid catabolism into a soluble, excretable form. (D)</p> Signup and view all the answers

Which of the following conditions is associated with an impaired urea cycle?

<p>Hyperammonemia (D)</p> Signup and view all the answers

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