12 Questions
What is the main genetic mutation responsible for the gray coat color and increased susceptibility to bacterial infections in collie puppies?
Mutation affecting melanocytes and bone marrow stem cells
Why do affected collie puppies experience recurrent bacterial infections?
Periodic depletion of neutrophils during neutropenia
What symptoms are typically observed in gray-coated collie puppies affected by the genetic disorder?
Joint pain, respiratory infections, and diarrhea
How does the cyclic neutropenia mutation affect the bone marrow stem cells?
Stops the production of early myeloid cells
Why do collies with the genetic disorder often die before six months of age?
As a result of recurrent bacterial infections and compromised immunity
What is the role of neutrophils in defending against bacterial infections?
Acting as primary innate defenders against bacterial attack
What is the primary reason for the increased susceptibility to bacterial infections in gray-coated collie puppies with the genetic disorder?
Fluctuating number of neutrophils in circulation
Which genetic mutation is responsible for both the gray coat color and the increased susceptibility to bacterial infections in collie puppies?
Mutation in the gene encoding AP3β1 protein
How does the cyclic neutropenia mutation affect the bone marrow of affected collie puppies?
Compromises production of early myeloid cells
Why do affected collie puppies exhibit symptoms like fever, joint pain, and respiratory infections?
Because of a cyclic arrest of cell maturation
What is the role of neutrophils in defending against bacterial infections in gray-coated collie puppies?
Secreting granular proteins for bacterial killing
How does the compromised production of early myeloid cells contribute to recurrent bacterial infections in collie puppies?
Results in a lack of neutrophils for defense
Learn about a genetic disorder in collies that results in a gray coat color and increased susceptibility to bacterial infections. Explore the symptoms that develop in affected puppies and the challenges they face. Image credit: Michelle Tennis.
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