Recent Lessons

Show all results for ""

Feature Overview

Ace your exams with our all-in-one platform for creating and sharing quizzes and tests.

Quizzes

Create quizzes and tests automatically from your content using AI.

Flashcards

Automatically turn your notes into digital flashcards.

Share, Export & Embed

Share with classmates or export to Excel and your learning management system.

Stats & Reporting

Auto-grading quizzes and tests with detailed stats and reports.

Mobile Apps

The smarter way to study – wherever you are.

Pricing

Search...

Clinical Correlation: Week 2 Gray-coated Collie Pup

12 Questions

0 Views

Clinical Correlation: Week 2 Gray-coated Collie Pup

Choose a study mode

Play Quiz

Study Flashcards

Spaced Repetition

Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the main genetic mutation responsible for the gray coat color and increased susceptibility to bacterial infections in collie puppies?

Genetic alteration impacting the trafficking of granular proteins

Gene mutation causing cyclic arrest of myeloid progenitor cells maturation

Mutation affecting melanocytes and bone marrow stem cells (correct)

Canine cyclic neutropenia mutation in the gene encoding the protein AP3β1

Why do affected collie puppies experience recurrent bacterial infections?

Periodic depletion of neutrophils during neutropenia (correct)

Increased eosinophils count resulting in immune system dysregulation

Elevated levels of lymphocytes causing immunodeficiency

Overproduction of monocytes leading to infection susceptibility

What symptoms are typically observed in gray-coated collie puppies affected by the genetic disorder?

Skin allergies and high fever

Increased platelet count and fatigue

Joint pain, respiratory infections, and diarrhea (correct)

Neurological deficits and muscle weakness

How does the cyclic neutropenia mutation affect the bone marrow stem cells?

Stops the production of early myeloid cells Signup and view all the answers

Why do collies with the genetic disorder often die before six months of age?

As a result of recurrent bacterial infections and compromised immunity Signup and view all the answers

What is the role of neutrophils in defending against bacterial infections?

Acting as primary innate defenders against bacterial attack Signup and view all the answers

What is the primary reason for the increased susceptibility to bacterial infections in gray-coated collie puppies with the genetic disorder?

Fluctuating number of neutrophils in circulation Signup and view all the answers

Which genetic mutation is responsible for both the gray coat color and the increased susceptibility to bacterial infections in collie puppies?

Mutation in the gene encoding AP3β1 protein Signup and view all the answers

How does the cyclic neutropenia mutation affect the bone marrow of affected collie puppies?

Compromises production of early myeloid cells Signup and view all the answers

Why do affected collie puppies exhibit symptoms like fever, joint pain, and respiratory infections?

Because of a cyclic arrest of cell maturation Signup and view all the answers

What is the role of neutrophils in defending against bacterial infections in gray-coated collie puppies?

Secreting granular proteins for bacterial killing Signup and view all the answers

How does the compromised production of early myeloid cells contribute to recurrent bacterial infections in collie puppies?

Results in a lack of neutrophils for defense Signup and view all the answers