Podcast
Questions and Answers
What is the main genetic mutation responsible for the gray coat color and increased susceptibility to bacterial infections in collie puppies?
What is the main genetic mutation responsible for the gray coat color and increased susceptibility to bacterial infections in collie puppies?
- Genetic alteration impacting the trafficking of granular proteins
- Gene mutation causing cyclic arrest of myeloid progenitor cells maturation
- Mutation affecting melanocytes and bone marrow stem cells (correct)
- Canine cyclic neutropenia mutation in the gene encoding the protein AP3β1
Why do affected collie puppies experience recurrent bacterial infections?
Why do affected collie puppies experience recurrent bacterial infections?
- Periodic depletion of neutrophils during neutropenia (correct)
- Increased eosinophils count resulting in immune system dysregulation
- Elevated levels of lymphocytes causing immunodeficiency
- Overproduction of monocytes leading to infection susceptibility
What symptoms are typically observed in gray-coated collie puppies affected by the genetic disorder?
What symptoms are typically observed in gray-coated collie puppies affected by the genetic disorder?
- Skin allergies and high fever
- Increased platelet count and fatigue
- Joint pain, respiratory infections, and diarrhea (correct)
- Neurological deficits and muscle weakness
How does the cyclic neutropenia mutation affect the bone marrow stem cells?
How does the cyclic neutropenia mutation affect the bone marrow stem cells?
Why do collies with the genetic disorder often die before six months of age?
Why do collies with the genetic disorder often die before six months of age?
What is the role of neutrophils in defending against bacterial infections?
What is the role of neutrophils in defending against bacterial infections?
What is the primary reason for the increased susceptibility to bacterial infections in gray-coated collie puppies with the genetic disorder?
What is the primary reason for the increased susceptibility to bacterial infections in gray-coated collie puppies with the genetic disorder?
Which genetic mutation is responsible for both the gray coat color and the increased susceptibility to bacterial infections in collie puppies?
Which genetic mutation is responsible for both the gray coat color and the increased susceptibility to bacterial infections in collie puppies?
How does the cyclic neutropenia mutation affect the bone marrow of affected collie puppies?
How does the cyclic neutropenia mutation affect the bone marrow of affected collie puppies?
Why do affected collie puppies exhibit symptoms like fever, joint pain, and respiratory infections?
Why do affected collie puppies exhibit symptoms like fever, joint pain, and respiratory infections?
What is the role of neutrophils in defending against bacterial infections in gray-coated collie puppies?
What is the role of neutrophils in defending against bacterial infections in gray-coated collie puppies?
How does the compromised production of early myeloid cells contribute to recurrent bacterial infections in collie puppies?
How does the compromised production of early myeloid cells contribute to recurrent bacterial infections in collie puppies?
