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Biochemistry LE 1: Introduction to Metabolism

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42 Questions

What is the primary purpose of anabolic pathways?

To synthesize complex molecules for cell maintenance, growth, and reproduction

What is the result of the transfer of electrons to O2 during the oxidation of macronutrients?

Energy is released as ATP

What is the effect of physical activity on metabolic rate?

It increases metabolic rate by 40-50%

What is the purpose of storing glycogen and triacylglycerides?

To store energy in between meals

What is the result of the oxidation of macronutrients?

CO2 and H2O are produced

What is the crossroads of catabolic and anabolic pathways?

Krebs Cycle/Tricarboxylic Cycle

What is the role of ATP in the cell?

To provide energy for biosynthetic reactions, muscle contraction, and active transport

Why is it not necessary to eat constantly?

Because there is a rest period that allows for energy storage in certain organs

What is the major fuel for oxidation in most tissues during the fed state?

Glucose

What is the result of decreased insulin secretion during fasting?

Decreased glucose uptake in muscle and adipose tissue

What is the ratio of CO2 produced to O2 consumed during the fed state?

Near 1

What happens to glucose transporters in muscle and adipose tissue during fasting?

They are internalized

What is the hormone that controls glucose uptake in muscle cells and adipose tissues during the fed state?

Insulin

What is the result of increased insulin secretion during the fed state?

Increased glucose uptake in muscle and adipose tissue

What is the purpose of glucose conservation during fasting?

To conserve glucose for essential tissues

What does a respiratory quotient (RQ) of less than 0.85 indicate?

Underfeeding

What is the primary source of metabolic fuel for certain tissues during prolonged fasting?

Ketone bodies

What happens to muscle glycogen during fasting?

It cannot contribute directly to plasma glucose

What is the effect of increased glucagon secretion on glycogen synthesis in the liver?

It inhibits glycogen synthesis

What happens to liver glycogen during prolonged fasting?

It drops and becomes depleted after 12 hours

What is the fate of amino acids during 7-day starvation?

They are used as the body's metabolic fuel

What happens to plasma glucose levels during prolonged fasting?

They decrease slightly

What is the effect of prolonged fasting on muscle protein degradation?

It decreases

What is the primary hormone responsible for the fasting state?

Glucagon

Why is triacylglycerol a preferred energy storage form?

Fatty acids in TAGS are more reduced.

What is an anabolic pathway?

Fatty acid synthesis

Which of the following is not a storage site for glycogen?

Adipose tissue

What is the end product of glycolysis in tissues using anaerobic metabolism?

Lactate

What is the preferred metabolic fuel of neurons in the fed state?

Glucose

What is the preferred metabolic fuel of neurons in the fasting state?

Acetoacetate

Which hormone is predominant in the fed state?

Insulin

Which amino acid can be used for gluconeogenesis?

Isoleucine

What is the reason why fatty acids release more energy during oxidation?

Because they have more hydrogens to lose during oxidation

Which type of cells are fatty acids stored in?

Adipocytes or fat cells

What is the result of low oxygen levels on pyruvate?

It is converted to lactate

What is the preferred metabolic fuel of neurons?

Glucose

What is the main source of fuel for the brain during starvation?

Ketone bodies

What is the result of the oxidation of fatty acids?

They release energy

What is the purpose of fatty acid synthesis?

To synthesize fatty acids for energy storage

What is the effect of high glucose levels on adipose tissue?

It increases the storage of fatty acids

What happens to pyruvate when oxygen levels are high?

It is converted to Acetyl-CoA

What is the role of adipocytes in the body?

To store fatty acids

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