Cell Cycle and Mitosis
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Questions and Answers

Which process is primarily responsible for increasing the number of cells in a multicellular organism during growth?

  • Meiosis
  • Fertilization
  • Asexual reproduction
  • Mitosis (correct)
  • What is the primary role of mitosis in tissue maintenance?

  • Ensuring genetic diversity
  • Replacing damaged or worn-out cells (correct)
  • Slowing down cell growth
  • Producing gametes for sexual reproduction
  • Which of the following best describes the relationship between mitosis and asexual reproduction?

  • Mitosis and asexual reproduction are completely independent processes
  • Mitosis directly results in increased genetic diversity
  • Asexual reproduction does not use mitosis
  • Mitosis is a process used during asexual reproduction, creating clones of the parent (correct)
  • What is a significant disadvantage of asexual reproduction compared to sexual reproduction?

    <p>Lack of genetic diversity (D)</p> Signup and view all the answers

    How does mitosis contribute to genetic stability?

    <p>By ensuring daughter cells have the same chromosome number and type as the parent cell (D)</p> Signup and view all the answers

    Which process is responsible for creating gametes required for sexual reproduction?

    <p>Meiosis (C)</p> Signup and view all the answers

    What process immediately follows fertilization in a sexually reproducing organism to produce many new cells?

    <p>Mitosis (A)</p> Signup and view all the answers

    What is the primary role of histones in the structure of chromosomes?

    <p>To organize and condense DNA into nucleosomes. (B)</p> Signup and view all the answers

    Why do chromosomes become more visible during cell division?

    <p>They coil tightly and condense, making them more dense. (A)</p> Signup and view all the answers

    What is the term for the identical copies of a chromosome formed during DNA replication?

    <p>Sister chromatids (A)</p> Signup and view all the answers

    How many pairs of sex chromosomes do humans typically have?

    <p>1 (D)</p> Signup and view all the answers

    What is the term for the complete set of chromosomes photographed and arranged in pairs?

    <p>Karyotype (B)</p> Signup and view all the answers

    What is the approximate distance between two nucleosomes, in terms of DNA's nucleotide length?

    <p>20 nucleotides (C)</p> Signup and view all the answers

    During which phase of the cell cycle are chromosomes uncoiled and difficult to observe under a microscope?

    <p>Interphase (D)</p> Signup and view all the answers

    If the DNA from a single human chromosome were stretched out end-to-end, what would its approximate length be equivalent to?

    <p>The length of a football field (A)</p> Signup and view all the answers

    What is the role of the "seal" applied to the open end of DNA, as mentioned in the text?

    <p>To protect the DNA from unraveling (C)</p> Signup and view all the answers

    During which phase of mitosis do the centromeres split, resulting in sister chromatids becoming individual chromosomes?

    <p>Anaphase (B)</p> Signup and view all the answers

    What is the primary role of spindle fibers during anaphase?

    <p>To pull the chromosomes towards opposite poles (B)</p> Signup and view all the answers

    Which of the following is a key characteristic of telophase?

    <p>Reformation of the nuclear envelope around each set of chromosomes (B)</p> Signup and view all the answers

    What distinguishes cytokinesis in animal cells from that of plant cells?

    <p>Animal cells form a contractile ring; plant cells form a cell plate. (C)</p> Signup and view all the answers

    What is the ultimate result of mitosis and cytokinesis?

    <p>Two genetically identical daughter cells (A)</p> Signup and view all the answers

    If a cell has 20 chromosomes prior to mitosis, how many chromosomes will each daughter cell have after cytokinesis?

    <p>20 chromosomes (A)</p> Signup and view all the answers

    What powers the movement of chromosomes during anaphase?

    <p>Active transport coupled with energy from ATP hydrolysis (D)</p> Signup and view all the answers

    What is the result of a failure in the cell cycle control mechanism?

    <p>Uncontrolled cell division (B)</p> Signup and view all the answers

    During which phase do chromosomes begin to uncoil and become less visible under a microscope?

    <p>Telophase (A)</p> Signup and view all the answers

    What process occurs after telophase to complete the division of cells?

    <p>Cytokinesis (A)</p> Signup and view all the answers

    What is the primary role of cyclins in the cell cycle?

    <p>To control the timing of the cell cycle (D)</p> Signup and view all the answers

    CDKs are essential because they activate the next phase of the cell cycle. What do they work in conjunction with?

    <p>Cyclins (D)</p> Signup and view all the answers

    Which of the following describes the function of checkpoints within the cell cycle?

    <p>To pause the cycle if critical processes are incomplete (A)</p> Signup and view all the answers

    Permanent cells, like nerve cells, differ from other cell types primarily because they:

    <p>Do not divide once formed (A)</p> Signup and view all the answers

    What ensures that each daughter cell has a complete set of chromosomes during cell division?

    <p>The duplication of chromosomes prior to division (B)</p> Signup and view all the answers

    What is the primary function of the spindle apparatus during mitosis?

    <p>To organize and separate chromosomes ensuring each daughter cell receives a complete set. (A)</p> Signup and view all the answers

    During which phase of interphase does DNA replication occur?

    <p>S phase (D)</p> Signup and view all the answers

    What is the significant outcome of the metaphase stage in mitosis?

    <p>The alignment of chromosomes at the cell's equator. (B)</p> Signup and view all the answers

    Which structural change happens to chromosomes during prophase?

    <p>They condense into visible structures, forming chromatids joined at the centromere. (C)</p> Signup and view all the answers

    Which event characterizes the G₂ phase of interphase?

    <p>The cell prepares for division by creating additional organelles and materials. (C)</p> Signup and view all the answers

    What is the role of the centrioles (in animal cells) during mitosis?

    <p>To initiate the formation of the spindle apparatus, which separates the chromosomes. (B)</p> Signup and view all the answers

    What happens to the nucleolus during prophase?

    <p>It breaks down and disappears. (D)</p> Signup and view all the answers

    Which of the following processes occurs during the S phase?

    <p>The cell replicates its DNA, creating sister chromatids. (D)</p> Signup and view all the answers

    What is the purpose of the G₁ phase of interphase?

    <p>The cell grows in size and collects materials needed for the next steps. (D)</p> Signup and view all the answers

    What is the structure of a chromosome just before the metaphase stage?

    <p>Two copies of a chromosome joined at the centromere, known as sister chromatids. (D)</p> Signup and view all the answers

    Flashcards

    Mitosis

    The process where a single cell divides into two identical daughter cells.

    Growth in multicellular organisms

    The growth of multicellular organisms happens by increasing the number of cells through mitosis.

    Repair and replacement

    Mitosis replaces damaged or worn-out cells, maintaining tissue health.

    Asexual reproduction

    Some organisms reproduce asexually through mitosis, producing offspring identical to the parent.

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    Sexual reproduction

    Sexual reproduction involves meiosis, which produces gametes (sex cells like egg and sperm).

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    Meiosis

    The process of creating gametes (sex cells) through cell division.

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    Fertilization

    The fusion of two gametes (egg and sperm) to form a zygote (the first cell of a new organism).

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    What are chromosomes?

    Chromosomes are thread-like structures found in the nucleus of every cell. They carry genetic information, like a set of instructions for building and maintaining an organism.

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    What is DNA and what does it do?

    DNA, or deoxyribonucleic acid, is a molecule that carries genetic instructions. It's essentially a code that dictates an organism's characteristics.

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    What are histones, and what do they do?

    Histones are proteins that help organize and condense DNA into compact bundles called nucleosomes.

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    What is a nucleosome?

    A nucleosome is a basic unit of DNA packaging. It consists of a length of DNA wrapped around a core of eight histone proteins.

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    What is a karyotype?

    A karyotype is a photographic representation of all the chromosomes in a cell, arranged in pairs according to size and shape.

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    When are chromosomes visible?

    Chromosomes are not always visible under a microscope. When a cell is not dividing, they are thin and uncoiled. However, when a cell is preparing to divide, chromosomes condense and become more visible.

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    How many chromosomes do humans have?

    Humans have 46 chromosomes arranged in 23 pairs. One chromosome in each pair comes from the mother and the other from the father.

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    What are sister chromatids?

    Sister chromatids are identical copies of a chromosome that are joined together during cell division.

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    What happens to sister chromatids during cell division?

    During mitosis, the sister chromatids separate and move to opposite ends of the cell, ensuring each daughter cell receives a complete set of chromosomes.

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    What are cyclins?

    Proteins that control the timing of the cell cycle.

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    What are CDKs?

    Enzymes that work with cyclins to activate the next phase of the cell cycle.

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    What are checkpoints in the cell cycle?

    The cell pauses the cycle if something goes wrong, like damaged DNA or incomplete replication.

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    What is asexual reproduction?

    A method of reproduction that produces genetically identical offspring.

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    What are permanent cells?

    Cells that do not divide once they're formed, like nerve and heart muscle cells.

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    What happens during Anaphase?

    The centromere divides, separating sister chromatids into individual chromosomes. Spindle fibers pull these chromosomes apart towards opposite ends of the cell.

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    What happens during Telophase?

    Chromosomes reach the poles of the cell and uncoil, becoming less visible. A nuclear envelope forms around each set of chromosomes.

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    How does cytokinesis happen in animal cells?

    A ring of contractile fibers forms around the cell's center and tightens, pinching the cell in two.

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    How does cytokinesis happen in plant cells?

    A cell plate forms at the center of the cell and develops into a new cell wall, dividing the two daughter cells.

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    What is the purpose of the cell cycle regulation?

    The cell cycle is tightly regulated to ensure that cells divide only when they are ready.

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    What happens if errors are detected in the cell cycle?

    If errors or damage are detected during the cell cycle, checkpoints can halt the process, giving the cell time to repair the problem.

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    Why is cell cycle regulation important for cancer prevention?

    Cell cycle regulation prevents uncontrolled cell division, which is a hallmark of cancer.

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    What triggers cell cycle checkpoints?

    The cell cycle checkpoints are triggered by signals inside and outside of the cell, coordinating the process of division.

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    G1 Phase: Cell Growth

    The cell grows in size and gathers materials needed for the next phase.

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    S Phase: DNA Replication

    The cell creates an exact copy of its DNA to ensure that each new cell gets a complete set of genetic instructions.

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    G2 Phase: Getting Ready

    The cell prepares for division by producing more organelles and other essential components.

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    Mitosis: Nuclear Division

    The cell divides its nucleus, ensuring each new cell gets an identical copy of the chromosomes.

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    Prophase: Preparing for Separation

    The chromosomes condense, become visible, and start attaching to spindle fibers. The nucleolus disappears, and centrioles (in animal cells) migrate to opposite poles.

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    Metaphase: Alignment and Attachment

    The chromosomes line up in the center of the cell at the metaphase plate. Spindle fibers attach to the centromere of each chromosome.

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    Anaphase: Pulling Apart

    The sister chromatids of each chromosome separate and move to opposite poles of the cell. The spindle fibers shorten, pulling the chromosomes apart.

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    Telophase: Final Steps

    The chromosomes reach the opposite poles of the cell and start to uncoil. The nuclear envelope reforms around each set of chromosomes, forming two new nuclei.

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    Cytokinesis: Division of the Cytoplasm

    The cytoplasm divides, creating two separate daughter cells. Each daughter cell receives one of the newly-formed nuclei and its own share of organelles.

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    The Importance of Cell Division

    The process of cell division allows for growth, repair of tissues, and reproduction in many organisms.

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    Study Notes

    Cell Cycle

    • The cell cycle is a repeating process where cells grow, divide, and form new cells.
    • This cycle has specific steps to ensure proper division.

    Cell Division and Reproduction

    • Mitosis (Main Type of Cell Division): A process where a single cell divides into two cells with identical DNA.
    • Purpose:
      • Growth: Multicellular organisms grow by increasing the number of cells through mitosis.
      • Repair and Replacement: Repair of worn-out or damaged cells, maintaining tissue health (e.g., skin and blood cells).
      • Asexual Reproduction: Some organisms reproduce asexually through mitosis, producing clones. (e.g., bacteria, some plants)
      • Genetic Stability: Ensures the daughter cells have the same number and type of chromosomes as the parent cell.

    Advantages of Asexual Reproduction

    • No need for a mate.
    • Rapid reproduction allows quick population growth.

    Disadvantages of Asexual Reproduction

    • Lack of genetic diversity, making populations vulnerable to environmental changes.

    Sexual Reproduction (Meiosis)

    • Depends on meiosis to create gametes (sex cells).
    • After fertilization (fusion of gametes), mitosis takes over to produce new cells for the developing organism.

    Chromosomes

    • Chromosomes are like "instruction manuals" inside each cell.

    • They carry all the genetic information (DNA).

    • Structure and Importance:

      • Made of DNA wrapped tightly around proteins called histones.
      • Histones act like spools for DNA.
      • Organize and condense DNA into neat bundles called nucleosomes.
      • Each nucleosome contains two turns of DNA wrapped around a set of eight histone proteins. The distance between 2 nucleosomes is almost 20 nucleotides.
      • This packaging is essential because DNA is extremely long; if stretched out, the DNA in one chromosome would be as long as a football field.

    Visibility of Chromosomes

    • Inactive Cell: When a cell is not dividing, chromosomes are thin, uncoiled, hard to see.
    • Dividing cell: Chromosomes coil tightly, become denser, easy to see under a microscope.

    How Chromosomes Work During Mitosis

    • Before division: Each chromosome is copied to create two identical copies (sister chromatids).
    • During Division: The chromatids are split and shared equally between two new cells, ensuring each daughter cell has the same DNA.

    Human Chromosome Count

    • Humans have 46 chromosomes (23 pairs).
    • One chromosome of each pair comes from the mother, the other from the father.

    Karyotype

    • A visual representation of all chromosomes in a cell, organized in pairs.
    • Helpful in diagnosing genetic disorders. Example: Humans have 22 pairs of autosomes (non-sex chromosomes) and 1 pair of sex chromosomes (XX for females, XY for males).

    Interphase (Preparation Phase)

    • It is the stage before mitosis, often referred to as the cell's resting stage.
    • However, it is highly active internally.
    • Key processes: DNA replication, organelle production, ATP production.
    • Interphase has three stages: G1, S, and G2.
    • G1 phase: The cell grows and collects materials needed for the next steps.
    • S phase: DNA replication occurs; single chromosomes become double-stranded.
    • G2 phase: Organelles and other materials are formed.

    Mitosis (Division of the Nucleus or karyokinesis)

    • Mitosis is divided into four distinct stages: Prophase, Metaphase, Anaphase, and Telophase. A helpful mnemonic is PMAT.
    • Prophase: Chromosomes condense, becoming visible; nuclear envelope breaks down; centrioles move to opposite poles in animal cells.
    • Metaphase: Chromosomes align along the center of the cell (metaphase plate); spindle fibers attach to centromeres.
    • Anaphase: Centromeres split; sister chromatids separate and move to opposite poles; spindle fibers pull the chromosomes.
    • Telophase: Two complete sets of chromosomes reach the poles and start to uncoil; nuclear envelope reforms around each set of chromosomes; spindle fibers disassemble; two distinct nuclei become visible.

    Cytokinesis (Division of the Cytoplasm)

    • Cell's cytoplasm divides, forming two separate cells.
    • Animal cells: A ring of contractile fibers forms around the cell's center, pinching the cell in two.
    • Plant cells: A cell plate forms at the center, developing into a new cell wall separating the two daughter cells.

    Mitotic Index

    • The mitotic index measures how actively cells in a tissue are dividing.
    • Calculated as the ratio of cells in mitosis to the total number of cells in a sample. Useful for monitoring cancer or other tissue health.

    Cell Cycle Control

    • Tightly regulated to ensure cell division takes place only when needed.
    • Cyclins and CDKs (Cyclin-Dependent Kinases) control the timing.

    Key Takeaways on Mitosis

    • Mitosis ensures that all new cells have the same DNA as the original. Mitosis is necessary for growth, cell repair and some forms of reproduction.
    • Chromosomes must be duplicated before dividing; each daughter cell receives a complete set during the process.
    • The cell cycle is precisely controlled using proteins like cyclins and CDKs.
    • Cells divide at different rates (some fast, some slow). This affects the rate of the cell cycle in different types of cells.

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