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Questions and Answers
What is the approximate percentage of living matter composed of carbon, hydrogen, oxygen, and nitrogen?
What is the approximate percentage of living matter composed of carbon, hydrogen, oxygen, and nitrogen?
Which subatomic particle has a positive charge?
Which subatomic particle has a positive charge?
What is the atomic number of an element defined by?
What is the atomic number of an element defined by?
What is the term for atoms of the same element that differ in the number of neutrons?
What is the term for atoms of the same element that differ in the number of neutrons?
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Which of the following is true about a cation?
Which of the following is true about a cation?
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What makes radioactive isotopes unstable?
What makes radioactive isotopes unstable?
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What determines the mass number of an atom?
What determines the mass number of an atom?
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Which of the following is NOT considered a trace element?
Which of the following is NOT considered a trace element?
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What is the primary role of a buffer in a biological system?
What is the primary role of a buffer in a biological system?
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Which of the following best describes the versatility of carbon in organic molecules?
Which of the following best describes the versatility of carbon in organic molecules?
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How does the structure of carbon chains contribute to the diversity of organic molecules?
How does the structure of carbon chains contribute to the diversity of organic molecules?
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How do functional groups contribute to the properties of organic molecules?
How do functional groups contribute to the properties of organic molecules?
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What primarily determines an atom's chemical behavior?
What primarily determines an atom's chemical behavior?
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How can two steroid hormones, such as estradiol and testosterone, with the same carbon skeleton have different properties?
How can two steroid hormones, such as estradiol and testosterone, with the same carbon skeleton have different properties?
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What is the term for electrons located in the outermost shell of an atom?
What is the term for electrons located in the outermost shell of an atom?
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What is the maximum number of electrons that the first electron shell of an atom can typically accommodate?
What is the maximum number of electrons that the first electron shell of an atom can typically accommodate?
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A covalent bond is formed by which process?
A covalent bond is formed by which process?
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What is the primary difference between a molecule and a compound?
What is the primary difference between a molecule and a compound?
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What does the term "valence" refer to in the context of an atom?
What does the term "valence" refer to in the context of an atom?
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What causes the formation of partial positive and negative charges within a molecule?
What causes the formation of partial positive and negative charges within a molecule?
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What is the primary distinction between polar and nonpolar covalent bonds?
What is the primary distinction between polar and nonpolar covalent bonds?
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What type of bond is formed due to the attraction between a cation and an anion?
What type of bond is formed due to the attraction between a cation and an anion?
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In an ionic compound, such as MgCl2, what does the formula represent?
In an ionic compound, such as MgCl2, what does the formula represent?
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What is required for the formation of a hydrogen bond?
What is required for the formation of a hydrogen bond?
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Which of the following is most associated with a 'hot spot' of positive or negative charge formation?
Which of the following is most associated with a 'hot spot' of positive or negative charge formation?
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What is the primary reason water is considered a versatile solvent?
What is the primary reason water is considered a versatile solvent?
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What is the term used to refer to the starting molecules of a chemical reaction?
What is the term used to refer to the starting molecules of a chemical reaction?
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What term describes a substance that does not have an affinity for water?
What term describes a substance that does not have an affinity for water?
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When is chemical equilibrium reached in a reversible reaction?
When is chemical equilibrium reached in a reversible reaction?
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What is the result of a water molecule gaining an extra proton?
What is the result of a water molecule gaining an extra proton?
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What is the pH of a neutral aqueous solution at 25°C?
What is the pH of a neutral aqueous solution at 25°C?
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Why is water considered a polar molecule?
Why is water considered a polar molecule?
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What is the role of a buffer in a solution?
What is the role of a buffer in a solution?
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In the context of chemical reactions, what is conserved?
In the context of chemical reactions, what is conserved?
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Which of the following represents a base according to the text?
Which of the following represents a base according to the text?
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What type of bond allows water to have a high degree of versatility as a solvent?
What type of bond allows water to have a high degree of versatility as a solvent?
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If a solution has a pH of 3, what is true about the solution?
If a solution has a pH of 3, what is true about the solution?
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Flashcards
Element
Element
A substance that cannot be broken down into simpler substances by chemical reactions.
Atom
Atom
The smallest unit of matter that retains the properties of an element.
Atomic number
Atomic number
The number of protons in an atom's nucleus.
Mass number
Mass number
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Isotopes
Isotopes
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Ion
Ion
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Electron’s energy
Electron’s energy
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Chemical bonding
Chemical bonding
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Electronegativity
Electronegativity
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Nonpolar covalent bond
Nonpolar covalent bond
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Polar covalent bond
Polar covalent bond
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Weak chemical bonds
Weak chemical bonds
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Covalent bond
Covalent bond
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Molecule
Molecule
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Compound
Compound
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Valence
Valence
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Ionic bond
Ionic bond
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Ionic compound
Ionic compound
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Hydrogen bond
Hydrogen bond
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Van der Waals interactions
Van der Waals interactions
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Chemical reaction
Chemical reaction
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Reactants
Reactants
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Products
Products
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Chemical equilibrium
Chemical equilibrium
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Polarity
Polarity
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Aqueous Solution
Aqueous Solution
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Hydrophilic
Hydrophilic
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Hydrophobic
Hydrophobic
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Water Dissociation
Water Dissociation
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pH
pH
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Acid
Acid
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Base
Base
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What is a buffer solution?
What is a buffer solution?
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Why is carbon important for life?
Why is carbon important for life?
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What are functional groups?
What are functional groups?
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What are hydrocarbons?
What are hydrocarbons?
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Why is carbon so versatile?
Why is carbon so versatile?
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Study Notes
Lecture 1: Chemical Biology
- Matter is composed of chemical elements in pure form or combined as compounds.
- An element's properties are determined by its atomic structure.
- Molecular formation and function depend on chemical bonds between atoms.
- Covalent bonds in water molecules lead to hydrogen bonding.
- Acidic and basic conditions influence living organisms' properties.
- Carbon forms diverse molecules by bonding with up to four other atoms.
- Specific chemical groups are essential for molecular function.
1.1 Atoms
- Each element consists of unique atoms, the smallest units maintaining element properties.
- Atoms are comprised of subatomic particles (neutrons, protons, and electrons).
- Neutrons and protons form the atomic nucleus.
- Electrons orbit the nucleus in electron clouds.
Elements
- Matter is comprised of elements that can't be broken down chemically.
- Approximately 20-25% of the 92 natural elements are crucial for life.
- The four most abundant elements in living matter are carbon, hydrogen, oxygen, and nitrogen (make up ~96% of living matter).
- Other essential elements include calcium, phosphorus, potassium, and sulfur (also vital components).
Table 2.1 Elements in the Human Body
- Provides the percentage of body mass for various elements, including major and trace elements.
- Oxygen accounts for 65.0% of the body's mass.
- Carbon accounts for 18.5% of the body's mass.
- Hydrogen constitutes 9.5% of the body's mass
- Additional elements contribute to the remaining 3.7%.
Atoms
- Each element is characterized by its unique atomic structure.
Atomic Number and Mass Number
- Atoms of different elements vary in the number of subatomic particles.
- Atomic number: the number of protons in an atom's nucleus
- Mass number: the total number of protons and neutrons in an atom.
- Approximate atomic mass can be determined from mass number (Protons + Neutrons).
Isotopes
- Atoms of the same element might have differing numbers of neutrons, thus generating isotopes.
- Radioactive isotopes decay spontaneously releasing particles and energy.
- Example: Carbon-12, Carbon-13, Carbon-14
Ions
- An ion is an atom or molecule with an unequal number of protons and electrons, conferring a net charge.
- A cation is formed when an atom loses an electron (positive charge).
- An anion is formed when an atom gains an electron (negative charge).
- Example: Sodium (Na+) and Chloride (Cl-)
Electrons' Energy
- Electrons in atoms have varying potential energies.
- Electron shells or energy levels describe these energy states (first shell, second shell, etc.).
- An atom's chemical behavior depends on the arrangements of electrons within these shells.
Periodic Table
- The periodic table displays elements' electron distributions.
- Rows represent periods reflecting atomic shell numbers.
- Columns correspond to additions of electrons in the valence shell.
- Valence electrons determine an atom's chemical reactivity.
- Atoms with complete valence shells (inert elements) exhibit stable chemical properties.
1.2 Chemical Bonds
- Covalent, ionic, hydrogen, and Van der Waals forces form bonds.
Covalent Bonds
- Atoms share one or more electron pairs to attain complete valence shells.
- Single, double, or triple bonds indicate multiple shared pairs.
- Molecules are formed from atoms held together by covalent bonds.
- Sharing of electrons may involve atoms of different elements.
- Example of molecules formed by covalent bonding: O2, H2O, CH4.
Valence
- Valence is the bonding capacity of an atom.
- Example: Valence numbers for H, O, N, and C are 1, 2, 3, and 4 respectively
Electronegativity
- Atoms exhibit varying attractions for shared electrons in covalent bonds (electronegativity).
- Nonpolar covalent bonds: Equal sharing of electrons.
- Polar covalent bonds: Unequal sharing of electrons results in partial charges on atoms.
Ionic Bonds
- Atoms gain or lose valence electrons, forming ions with opposite charges.
- An ionic bond results from the electrostatic attraction between oppositely charged ions.
Ionic Compounds
- Ionic compounds, also called salts, are formed from ionic bonds.
- Unlike molecules, ionic compounds form crystal lattices rather than distinct molecules.
Hydrogen Bonds
- A hydrogen bond forms when a hydrogen atom covalently bonded to an electronegative atom (like oxygen or nitrogen) is attracted to another electronegative atom.
Van der Waals Interactions
- Weak attractions between molecules due to temporary, fluctuating charges.
- These attractions can be significant when many molecules interact.
Chemical Reactions
- Chemical reactions involve the making and breaking of chemical bonds.
- Reactants are transformed into products.
- Matter is conserved (atoms are neither created nor destroyed).
- Most reactions are reversible (products can revert to reactants).
- Chemical equilibrium occurs when forward and reverse rates are equal.
1.3 Water and pH
Water as a Polar Molecule
- Water's polarity arises from the oxygen atom's high electronegativity.
- Water molecules form hydrogen bonds with each other due to their polarity.
Aqueous Solutions
- In an aqueous solution, water is the solvent, dissolving other substances.
- Water's polarity makes it a versatile solvent.
- When ionic solutes are dissolved in water, they're surrounded by water molecules (hydration shell).
Dissolution of Nonionic Molecules
- Water can dissolve nonionic polar substances if they have polar or ionic parts.
- Polar molecules (hydrophilic) have affinity for water.
- Nonpolar molecules (hydrophobic) do not have an affinity for water.
Water Dissociation
- A hydrogen atom can shift between water molecules causing dissociation into H+ and OH- ions.
- Water molecules, with extra protons, become hydronium (H3O+ ) while hydroxyl (OH-) ions are formed.
pH
- pH quantifies a solution's hydrogen ion (H+) concentration.
- pH scale ranges from 0 to 14.
- pH 7 is neutral
- pH values less than 7 indicate acidity.
- pH values greater than 7 indicate alkalinity.
pH Scale
- A scale for measuring the acidity or basicity of a solution.
- Acids increase H+ concentration.
- Bases decrease H+ concentration.
- pH affects the chemical properties and functions in biological organisms.
Buffers
- Buffers resist changes in pH by absorbing and releasing H+ ions.
- Crucial to maintain stable biological conditions.
- Example: carbonic acid-bicarbonate system.
1.4 Organic Molecules
- Most biological molecules are carbon-based.
- Carbon forms extensive complex molecules with many diverse shapes and properties.
Life is carbon-based
- Living organisms are largely composed of carbon compounds.
- Carbon's ability to form numerous bonds facilitates the diversity of complex organic molecules.
- Organic compounds include proteins, DNA, and carbohydrates
Versatility of Carbon
- Carbon's electron configuration allows for diverse covalent bonding partnerships.
- Valency: Number of bonds carbon can form—four.
- Hydrogen(H): one bond
- Oxygen (O): two bonds
- Nitrogen (N): three bonds.
Carbon Skeleton
- Carbon chains form the backbones of most organic molecules.
- Carbon chain length, branching, double bond positioning, and ring structure influence properties.
- Hydrocarbons are organic molecules built from only carbon and hydrogen.
Importance of Functional Groups
- Functional groups: Groups of atoms attached to the carbon skeleton.
- They impart specific properties to organic molecules and participate in many reactions.
- Example: Estrogen and testosterone (steroids)
Hydroxyl and Carbonyl Groups
-
Hydroxyl (–OH) group: makes molecules soluble in water; important in alcohols.
-
Carbonyl (C=O) group: found in ketones and aldehydes, sugars and other molecules.
Carboxyl and Amino Groups
- Carboxyl (-COOH) group: acts as an acid, donating H+ ions; crucial for organic acids (like acetic acid) and contributing to a molecule's polarity.
- Amino (-NH2) group: acts as a base, accepting H+ ions; vital for amines and amino acids.
Phosphate and Methyl Groups
- Phosphate (-OPO32-) group: contributes negative charge and releases energy when hydrolyzed; essential for many biological molecules such as ATP.
- Methyl (-CH3) group: affects gene expression and shapes proteins or hormones by modifying its molecules.
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Description
Test your knowledge on the fundamental concepts of chemistry relevant to biology. This quiz covers topics such as the composition of living matter, atomic structure, isotopes, and the role of functional groups in organic molecules. Perfect for students studying biology or chemistry!