Biologic Therapies for Inflammatory Bowel Disease Quiz

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19 Questions

Which mechanism of action is predominantly responsible for the lympholytic properties of glucocorticoids?

Ability to modify cellular functions

What is the primary target of the immunosuppressive drug cyclosporine A?

Calcineurin Phosphatase

Which biologic therapy is associated with binding to the alpha4 subunit of integrins on leukocyte surfaces?

Natalizumab

What is the major mechanism by which adalimumab reduces inflammation in diseases like psoriatic arthritis?

Blocking TNFa binding with its receptor

How do hybridoma technology-derived monoclonal antibodies differ from non-hybridoma antibodies?

Contain variable regions from mice

Why is it important that azathioprine interferes with purine biosynthesis?

It inhibits lymphoid cell proliferation after antigen stimulation

What is the function of azathioprine as an anti-metabolite?

Kills proliferative cells

Why should patients on allopurinol for hyperuricemia receive a reduced dose of azathioprine?

To prevent inactivation of azathioprine

Which immune response is primarily affected by azathioprine's interference with purine biosynthesis?

Cellular immunity

What role does azathioprine play in lymphoid cell proliferation following antigen stimulation?

Inhibits proliferation

What is the first line of defense against pathogens such as bacteria, viruses, fungi, and parasites?

Complement system

Which type of T cells require previous exposure to antigens?

T Helper Cells TH1 and TH2 cells

What revolutionary technology in antibody production was introduced by Milstein and Kohler in 1975?

Hybridoma technology

In hybridomas, what two types of cells are fused together to produce specific antibodies?

Antibody-forming cells and immortal plasmacytoma cells

Which type of antibodies involve replacing most of the murine antibody with equivalent human regions?

Humanized antibodies

What is the brand name of Adalimumab

Humira

Brand Name for Cetrolizumab

Cimzia

The brand name for Golimumab?

Simponi

Brand name for infliximab

Remicade

Test your knowledge on biologic therapies used for treating Inflammatory Bowel Disease, including Chimeric Monoclonal Antibodies and other drugs such as Cyclosporine and Methotrexate. Learn about the immune system's role in fighting pathogens and the use of TNF antagonists in treatment.

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