Biologic Therapies for Inflammatory Bowel Disease Quiz
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Biologic Therapies for Inflammatory Bowel Disease Quiz

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@ContrastyDrums

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Questions and Answers

Which mechanism of action is predominantly responsible for the lympholytic properties of glucocorticoids?

  • Direct cytotoxicity to T cells
  • Enhancement of humoral immunity
  • Induction of cytokine release
  • Ability to modify cellular functions (correct)

    • What is the primary target of the immunosuppressive drug cyclosporine A?

  • Calcineurin Phosphatase (correct)
  • Cytotoxic T cells
  • IgG immunoglobulins
  • Tumor necrosis factor alpha

    • Which biologic therapy is associated with binding to the alpha4 subunit of integrins on leukocyte surfaces?

  • Certolizumab pegol
  • Adalimumab
  • Golimumab
  • Natalizumab (correct)

    • What is the major mechanism by which adalimumab reduces inflammation in diseases like psoriatic arthritis?

    <p>Blocking TNFa binding with its receptor</p> Signup and view all the answers

    How do hybridoma technology-derived monoclonal antibodies differ from non-hybridoma antibodies?

    <p>Contain variable regions from mice</p> Signup and view all the answers

    Why is it important that azathioprine interferes with purine biosynthesis?

    <p>It inhibits lymphoid cell proliferation after antigen stimulation</p> Signup and view all the answers

    What is the function of azathioprine as an anti-metabolite?

    <p>Kills proliferative cells</p> Signup and view all the answers

    Why should patients on allopurinol for hyperuricemia receive a reduced dose of azathioprine?

    <p>To prevent inactivation of azathioprine</p> Signup and view all the answers

    Which immune response is primarily affected by azathioprine's interference with purine biosynthesis?

    <p>Cellular immunity</p> Signup and view all the answers

    What role does azathioprine play in lymphoid cell proliferation following antigen stimulation?

    <p>Inhibits proliferation</p> Signup and view all the answers

    What is the first line of defense against pathogens such as bacteria, viruses, fungi, and parasites?

    <p>Complement system</p> Signup and view all the answers

    Which type of T cells require previous exposure to antigens?

    <p>T Helper Cells TH1 and TH2 cells</p> Signup and view all the answers

    What revolutionary technology in antibody production was introduced by Milstein and Kohler in 1975?

    <p>Hybridoma technology</p> Signup and view all the answers

    In hybridomas, what two types of cells are fused together to produce specific antibodies?

    <p>Antibody-forming cells and immortal plasmacytoma cells</p> Signup and view all the answers

    Which type of antibodies involve replacing most of the murine antibody with equivalent human regions?

    <p>Humanized antibodies</p> Signup and view all the answers

    What is the brand name of Adalimumab

    <p>Humira</p> Signup and view all the answers

    Brand Name for Cetrolizumab

    <p>Cimzia</p> Signup and view all the answers

    The brand name for Golimumab?

    <p>Simponi</p> Signup and view all the answers

    Brand name for infliximab

    <p>Remicade</p> Signup and view all the answers

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