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Questions and Answers
Which treatment is typically recommended as first-line therapy for mild-moderate distal ulcerative colitis?
Which treatment is typically recommended as first-line therapy for mild-moderate distal ulcerative colitis?
What is the appropriate pharmacologic treatment option for proctitis in ulcerative colitis?
What is the appropriate pharmacologic treatment option for proctitis in ulcerative colitis?
In patients with moderate-severe ulcerative colitis who do not respond to prednisone, what alternative treatments may be considered?
In patients with moderate-severe ulcerative colitis who do not respond to prednisone, what alternative treatments may be considered?
What is the site of disease for extensive colitis in ulcerative colitis?
What is the site of disease for extensive colitis in ulcerative colitis?
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What is the first-line therapy for mild-moderate extensive ulcerative colitis in active disease?
What is the first-line therapy for mild-moderate extensive ulcerative colitis in active disease?
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Which of the following is NOT an appropriate remission/maintenance therapy for mild-moderate distal UC?
Which of the following is NOT an appropriate remission/maintenance therapy for mild-moderate distal UC?
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For severe-fulminant ulcerative colitis refractory to IV corticosteroids, what treatment could be considered next?
For severe-fulminant ulcerative colitis refractory to IV corticosteroids, what treatment could be considered next?
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What is the appropriate pharmacologic treatment option for pancolitis in ulcerative colitis?
What is the appropriate pharmacologic treatment option for pancolitis in ulcerative colitis?
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What is the recommended pharmacologic approach for refractory ulcerative colitis after attempting IV cyclosporine therapy?
What is the recommended pharmacologic approach for refractory ulcerative colitis after attempting IV cyclosporine therapy?
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Which treatment option should be considered for maintenance therapy in UC after achieving remission with IV hydrocortisone?
Which treatment option should be considered for maintenance therapy in UC after achieving remission with IV hydrocortisone?
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Flashcards
Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Disease (IBD)
A chronic gastrointestinal (GI) condition causing gut inflammation, including Ulcerative Colitis (UC) and Crohn's Disease (CD).
Ulcerative Colitis (UC)
Ulcerative Colitis (UC)
A type of IBD causing chronic inflammation of the colon, often leading to rectal bleeding, diarrhea, and abdominal pain.
UC Treatment (Mild-Moderate Distal)
UC Treatment (Mild-Moderate Distal)
First-line: Topical aminosalicylates (enema/suppository). Mesalamine if needed. May combine oral and topical aminosalicylates.
UC Treatment (Mild-Moderate Extensive)
UC Treatment (Mild-Moderate Extensive)
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UC Treatment (Moderate-Severe)
UC Treatment (Moderate-Severe)
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UC Treatment (Severe-Fulminant)
UC Treatment (Severe-Fulminant)
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Irritable Bowel Syndrome (IBS)
Irritable Bowel Syndrome (IBS)
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IBS Treatment Options
IBS Treatment Options
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Factors in UC Pathophysiology
Factors in UC Pathophysiology
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UC Treatment - Proctitis
UC Treatment - Proctitis
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Study Notes
Inflammatory Bowel Disease (IBD)
- IBD is a chronic GI condition characterized by inflammation of the gut, including Ulcerative Colitis (UC) and Crohn's Disease (CD)
- UC is a type of IBD characterized by chronic inflammation of the colon
Ulcerative Colitis (UC)
- Definition: UC is a chronic inflammation of the colon, characterized by rectal bleeding, diarrhea, and abdominal pain
- Epidemiology:
- Prevalence: 10% worldwide among adults
- More predominant in younger patients and women
- Pathophysiology:
- Results from altered somatovisceral and motor dysfunction of the intestine
- Abnormal CNS processing of afferent signals may lead to visceral hypersensitivity
- Factors contributing to alterations include genetics, motility, inflammation, colonic infections, mechanical irritation, stress, and psychological factors
Treatment of UC
- Treatment is based on:
- Type of UC (UC vs CD)
- Severity (Mild, Moderate, Severe, Fulminant)
- Site of disease (Proctitis, Distal disease, Extensive disease, Small intestine involvement)
- Need for acute treatment or maintenance therapy
- Treatment options:
- Topical agents (suppository) for proctitis
- Systemic or topical therapy or combination for distal disease
- Systemic agents for extensive colitis
- May add topical therapy if needed/appropriate
- Mild-Moderate Distal UC:
- First-line treatment: Topical aminosalicylates (enema/suppository)
- Mesalamine if inadequate or no response
- May combine oral and topical aminosalicylates
- Mild-Moderate Extensive UC:
- First-line treatment: Oral aminosalicylate
- Budesonide (Uceris) 9 mg/d
- Sulfasalazine or Mesalamine
- Moderate-Severe UC:
- First-line treatment: Budesonide 9 mg/day
- Prednisone 40-60 mg/d
- Add azathioprine, mercaptopurine, infliximab, adalimumab, or golimumab if no response
- Severe-Fulminant UC:
- Treatment: Methylprednisolone 40-60 mg daily for 3-5 days
- IV cyclosporine or infliximab if refractory to IV corticosteroids
- Add azathioprine, mercaptopurine, infliximab, certolizumab, adalimumab, vedolizumab or tofacitinib if remission achieved
- Attempt to withdraw prednisone after 1-2 months
Irritable Bowel Syndrome (IBS)
- Definition: IBS is a GI syndrome characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause
- Epidemiology:
- Prevalence: 10% worldwide among adults
- More predominant in younger patients and women
- Pathophysiology:
- Results from altered somatovisceral and motor dysfunction of the intestine
- Abnormal CNS processing of afferent signals may lead to visceral hypersensitivity
- Factors contributing to alterations include genetics, motility, inflammation, colonic infections, mechanical irritation, stress, and psychological factors
Treatment of IBS
- Treatment options:
- Linaclotide
- Rifaximin
- Tegaserod
- Plecanatide
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Description
Test your knowledge of pharmacotherapy options for inflammatory bowel disease with this quiz. Learn about medications such as Linaclotide, Rifaximin, Tegaserod, and Plecanatide referenced in the 'DiPiro's Pharmacotherapy: A Pathophysiologic Approach' textbook.
