Antigen Structure, Processing and Presentation - Dr. Muna Oqal
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Questions and Answers

What are the specific areas on the antigen molecule that react with antibodies called?

  • Conformational determinants
  • Antibody sites
  • Sequential determinants
  • Antigenic determinants or epitopes (correct)
  • Which type of antigenic determinants are recognized mainly by T cells?

  • Conformational determinants
  • Bacterial antigens
  • Sequential (or linear) determinants (correct)
  • Pure proteins
  • Which type of antigens are poorly immunogenic?

  • Pure proteins
  • Polysaccharides
  • Nucleic Acids (correct)
  • Lipids
  • What is the characteristic of lipid antigens in terms of immunogenicity?

    <p>Non-immunogenic</p> Signup and view all the answers

    What type of antigens have entered the body from the outside by inhalation, ingestion, or injection?

    <p>Exogenous antigens</p> Signup and view all the answers

    What are the antigenic determinants that consist of amino acid residues spatially juxtaposed in the folded protein called?

    <p>Conformational determinants</p> Signup and view all the answers

    How are exogenous antigens mainly taken up by antigen processing cells (APCs)?

    <p>By phagocytosis</p> Signup and view all the answers

    What are endogenous antigens?

    <p>Antigens that are generated within cells</p> Signup and view all the answers

    Which of the following is an example of human tissue antigen?

    <p>Blood group antigens A, B, and Rh</p> Signup and view all the answers

    What is the role of major histocompatibility complex antigens (MHC)?

    <p>Presenting antigens to T cells</p> Signup and view all the answers

    How can some exogenous antigens transform into endogenous antigens?

    <p>Through a process mediated by MHC molecules</p> Signup and view all the answers

    Which of the following is NOT a type of antigen according to the text?

    <p>Nucleotides</p> Signup and view all the answers

    What is the definition of an immunogen based on the text?

    <p>A stimulus that generates antibodies</p> Signup and view all the answers

    Which term describes substances that become immunogenic by coupling to a larger carrier molecule?

    <p>Haptens</p> Signup and view all the answers

    What type of antigens can be conjugates of lipids with proteins?

    <p>Lipoproteins</p> Signup and view all the answers

    Which substances are capable of generating an immune response by themselves?

    <p>Immunogens</p> Signup and view all the answers

    What does MHC stand for in the context of antigen processing and presentation?

    <p>Major Histocompatibility Complex</p> Signup and view all the answers

    What is the role of high molecular weight antigens in inducing an immune response?

    <p>They require a carrier molecule to act as a complete antigen</p> Signup and view all the answers

    Which of the following properties can make molecules more effective antigens?

    <p>Having distinctive shapes and novel subunit combinations</p> Signup and view all the answers

    What are antigenic determinants also known as?

    <p>Epitopes</p> Signup and view all the answers

    Why do high molecular weight antigens require carrier molecules to act as complete antigens?

    <p>Because they are incomplete antigens by themselves</p> Signup and view all the answers

    What is the significance of the route of administration in antigenicity?

    <p>Parenteral routes are more immunogenic compared to oral routes</p> Signup and view all the answers

    Which type of molecules are less likely to be effective antigens?

    <p>Molecules lacking distinctive shapes and novel subunit combinations</p> Signup and view all the answers

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