Antifungal Susceptibility Testing and Fungal Cell Characteristics

Fungi are ______ with membrane bound organelles

In vitro antifungal susceptibility testing differ from that of bacteria because fungi may be in the form of ______ or filamentous fungi

Yeast – Candida, Cryptococcus neoformans, ______

Systemic infections are life threatening like a)Aspergillosis – Brooder pneumonia and mycotic abortion b)Blastomycosis – ______ c)Histoplasmosis – Invade macrophages of host and disseminate to lungs d)Cryptococcosis – Granuloma of alveoli and urinary tract

Sites of action of antifungal drugs: Cell wall - Ecchinocandins - ______

Others -Griseofulvin ->inhibit mitosis ->interfere with polymerisation of microtubule and disorganise the ______ formation

Fungi are ______ with membrane bound organelles and have common cellular characteristics with mammalian cell.

In vitro antifungal susceptibility testing differ from that of bacteria because fungi may be in the form of yeast or ______ fungi

Yeast – Candida, Cryptococcus neoformans, ______

Mycelial form – ______

Decrease the uptake of drug, Efflux, reduced affinity of target enzymes – ______

Dimorphic fungi – Blastomyces, Coccidioides, ______

Topical infections caused by a variety of ______

Systemic infections are life threatening like a)Aspergillosis – Brooder pneumonia and mycotic abortion b)Blastomycosis – ______ c)Histoplasmosis – Invade macrophages of host and disseminate to lungs d)Cryptococcosis – Granuloma of alveoli and urinary tract

Dermatophytes establish on the ______

Sites of action of antifungal drugs: Cell wall - Ecchinocandins - Caspofungin, Cell membrane - Polyenes - Amphotericin B; Nystatin; Natamycin o Azoles - Imidazole - Ketoconazole, Miconazole, Enilconazole, clotrimazole, Triazole - Fluconazole, Itraconazole, Voriconazole o Allylamines - Terbinafine , Naftidine Nucleic acid synthesis - 5 - ______