Antifungal Susceptibility Testing and Fungal Cell Characteristics
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Questions and Answers

Fungi are ______ with membrane bound organelles

eukaryotes

In vitro antifungal susceptibility testing differ from that of bacteria because fungi may be in the form of ______ or filamentous fungi

yeast

Yeast – Candida, Cryptococcus neoformans, ______

Malassezia

Systemic infections are life threatening like a)Aspergillosis – Brooder pneumonia and mycotic abortion b)Blastomycosis – ______ c)Histoplasmosis – Invade macrophages of host and disseminate to lungs d)Cryptococcosis – Granuloma of alveoli and urinary tract

<p>lungs</p> Signup and view all the answers

Sites of action of antifungal drugs: Cell wall - Ecchinocandins - ______

<p>Caspofungin</p> Signup and view all the answers

Others -Griseofulvin ->inhibit mitosis ->interfere with polymerisation of microtubule and disorganise the ______ formation

<p>spindle</p> Signup and view all the answers

Fungi are ______ with membrane bound organelles and have common cellular characteristics with mammalian cell.

<p>eukaryotes</p> Signup and view all the answers

In vitro antifungal susceptibility testing differ from that of bacteria because fungi may be in the form of yeast or ______ fungi

<p>filamentous</p> Signup and view all the answers

Yeast – Candida, Cryptococcus neoformans, ______

<p>Malassezia</p> Signup and view all the answers

Mycelial form – ______

<p>Sporothrix</p> Signup and view all the answers

Decrease the uptake of drug, Efflux, reduced affinity of target enzymes – ______

<p>drug resistance</p> Signup and view all the answers

Dimorphic fungi – Blastomyces, Coccidioides, ______

<p>Histoplasma</p> Signup and view all the answers

Topical infections caused by a variety of ______

<p>fungi</p> Signup and view all the answers

Systemic infections are life threatening like a)Aspergillosis – Brooder pneumonia and mycotic abortion b)Blastomycosis – ______ c)Histoplasmosis – Invade macrophages of host and disseminate to lungs d)Cryptococcosis – Granuloma of alveoli and urinary tract

<p>lungs</p> Signup and view all the answers

Dermatophytes establish on the ______

<p>skin</p> Signup and view all the answers

Sites of action of antifungal drugs: Cell wall - Ecchinocandins - Caspofungin, Cell membrane - Polyenes - Amphotericin B; Nystatin; Natamycin o Azoles - Imidazole - Ketoconazole, Miconazole, Enilconazole, clotrimazole, Triazole - Fluconazole, Itraconazole, Voriconazole o Allylamines - Terbinafine , Naftidine Nucleic acid synthesis - 5 - ______

<p>Flucytosine</p> Signup and view all the answers

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