6 Questions
What is the primary function of ergosterols in fungi?
To maintain the fluidity and permeability of the cell membrane
Which class of antifungal drugs targets the enzyme CYP51 in the ergosterol biosynthesis pathway?
Azoles
What is the primary mechanism of action of polyene antifungal drugs?
Binding to ergosterols and increasing membrane permeability
Which class of antifungal drugs inhibits the synthesis of β-D-glucan in the fungal cell wall?
Echinocandins
What is the primary mechanism of action of allylamine antifungal drugs?
Inhibiting the conversion of squalene to lanosterol
Which statement about antifungal drugs targeting ergosterols is correct?
They are selectively toxic to fungi due to targeting fungal ergosterols and not mammalian cholesterol
Learn about antifungal drugs used to treat fungal infections, their mechanism of action, and how they target fungal ergosterols. Explore the unique characteristics of fungi as eukaryotic organisms and understand the main classes of antifungal drugs such as polyenes, azoles, allylamines, and echinocandins.
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