Antifungal Drugs and Fungi
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Questions and Answers

What is the primary function of ergosterols in fungi?

  • To facilitate the transport of nutrients into the cell
  • To act as an energy source for cellular processes
  • To maintain the fluidity and permeability of the cell membrane (correct)
  • To provide structural integrity to the cell wall

Which class of antifungal drugs targets the enzyme CYP51 in the ergosterol biosynthesis pathway?

  • Echinocandins
  • Polyenes
  • Azoles (correct)
  • Allylamines

What is the primary mechanism of action of polyene antifungal drugs?

  • Inhibiting the enzyme CYP51 in the ergosterol biosynthesis pathway
  • Inhibiting the conversion of squalene to lanosterol
  • Disrupting the synthesis of β-D-glucan in the cell wall
  • Binding to ergosterols and increasing membrane permeability (correct)

Which class of antifungal drugs inhibits the synthesis of β-D-glucan in the fungal cell wall?

<p>Echinocandins (B)</p> Signup and view all the answers

What is the primary mechanism of action of allylamine antifungal drugs?

<p>Inhibiting the conversion of squalene to lanosterol (B)</p> Signup and view all the answers

Which statement about antifungal drugs targeting ergosterols is correct?

<p>They are selectively toxic to fungi due to targeting fungal ergosterols and not mammalian cholesterol (C)</p> Signup and view all the answers

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