Anemia Classification and Iron Deficiency

What is the mean corpuscular volume (MCV) range for normocytic anemia?

Which clinical feature is most specifically associated with iron deficiency anemia?

Which of the following is NOT a cause of iron deficiency anemia?

What is the recommended daily iron intake for adult females?

Which enzyme is NOT involved in the synthesis of heme?

Which laboratory finding is typically low in iron deficiency anemia?

What is a common treatment option for sideroblastic anemia?

What distinguishes anemia of chronic disease from iron deficiency anemia?

Which enzyme deficiency is associated with sideroblastic anemia?

What is the expected reticulocyte count in anemic adults with competent bone marrow function?

Which of the following lab findings can be seen in sideroblastic anemia?

What role does hepcidin play in anemia of chronic disease?

Which type of anemia is often linked to myelodysplastic syndromes?

What finding is characteristic of the peripheral blood smear in sideroblastic anemia?

Which inflammatory cytokine is associated with anemia of chronic disease?

Normocytic Anemia

Mean corpuscular volume (MCV) range: 80-100 fL

Iron Deficiency Anemia

Most specific clinical feature: Koilonychia (spoon-shaped nails)

Causes of Iron Deficiency Anemia

NOT a cause: Lack of intrinsic factor (this is associated with Vitamin B12 deficiency)

Iron Intake

Recommended daily iron intake for adult females: 18 mg

Heme Synthesis Enzymes

Enzyme NOT involved: Dihydrofolate reductase (involved in folate metabolism)

Iron Deficiency Anemia Lab Findings

Typically low: Serum ferritin (iron storage protein)

Siderblastic Anemia Treatment

Common treatment: Pyridoxine (vitamin B6)

Anemia of Chronic Disease vs. Iron Deficiency Anemia

Distinguishing factor: Serum ferritin levels are normal or even elevated in anemia of chronic disease, while they are low in iron deficiency anemia.

Sideroblastic Anemia Enzyme Deficiency

Enzyme deficiency: δ-aminolevulinate synthase (key enzyme in heme synthesis)

Reticulocyte Count in Anemic Adults

Expected reticulocyte count: Increased (indicates bone marrow is responding to anemia)

Sideroblastic Anemia Lab Findings

Lab finding seen: Ring sideroblasts (red blood cells with iron-laden mitochondria)

Hepcidin Role in Anemia of Chronic Disease

Hepcidin: Inhibits iron absorption and release from macrophages, contributing to anemia

Anemia Linked to Myelodysplastic Syndromes

Anemia type: Sideroblastic anemia

Peripheral Blood Smear Finding in Sideroblastic Anemia

Characteristic finding: Basophilic stippling (blue-staining granules in red blood cells)

Inflammatory Cytokine in Anemia of Chronic Disease

Associated inflammatory cytokine: TNF-α (Tumor Necrosis Factor-alpha)

This quiz covers the classification of anemia, focusing specifically on microcytic anemias such as iron deficiency anemia. You will learn about prevalence rates, the importance of iron in hemoglobin, and the synthesis of heme. Test your knowledge on the types and implications of anemia.