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Questions and Answers
What classification does AML minimally differentiated correspond to?
What classification does AML minimally differentiated correspond to?
What classification does AML without maturation correspond to?
What classification does AML without maturation correspond to?
What classification does Acute Promyelocytic Leukemia correspond to?
What classification does Acute Promyelocytic Leukemia correspond to?
What is the classification for Acute Myelomonocytic leukemia?
What is the classification for Acute Myelomonocytic leukemia?
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Which classification is associated with DIC & Faggot Cells?
Which classification is associated with DIC & Faggot Cells?
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Acute Monocytic leukemia well differentiated is classified as _____
Acute Monocytic leukemia well differentiated is classified as _____
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What classification demonstrates Auer rods?
What classification demonstrates Auer rods?
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The Acute promyelocytic leukemia microgranular variant is associated with M3.
The Acute promyelocytic leukemia microgranular variant is associated with M3.
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What is another name for Acute Myelomonocytic leukemia?
What is another name for Acute Myelomonocytic leukemia?
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Which AML subtype is seen in children and has >80% monoblasts in BM?
Which AML subtype is seen in children and has >80% monoblasts in BM?
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Which classification is the most common subtype of AML?
Which classification is the most common subtype of AML?
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Acute Myelomonocytic leukemia with eosinophilia is classified as _____
Acute Myelomonocytic leukemia with eosinophilia is classified as _____
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Study Notes
AML Classification Overview
- AML minimally differentiated is identified as M0.
- M1 refers to AML without maturation.
- M2 designates AML with maturation, being the most common subtype of AML.
- M3 is Acute Promyelocytic Leukemia, associated with disseminated intravascular coagulation (DIC) and the presence of Faggot cells.
- The microgranular variant of Acute Promyelocytic Leukemia is termed M3V, characterized by "butterfly," "bowtie," or "apple core" shaped cells.
Key Subtypes
- Acute Myelomonocytic leukemia is classified as M4, known to be the second most common subtype of AML.
- M4E indicates Acute Myelomonocytic Leukemia with eosinophilia.
- Acute Monocytic Leukemia comprises two distinct subtypes:
- M5a is poorly differentiated, often seen in children with over 80% monoblasts in the bone marrow.
- M5b is well differentiated and typically seen in middle-aged adults.
Important Characteristics
- M0 has a negative myeloperoxidase (MPO) and Sudan Black B (SBB) stain.
- Subtypes M1, M2, M3, and M6 may demonstrate Auer rods, which are characteristic cytoplasmic inclusions in myeloid cells.
- M1, M4 subtypes may show Acquired Pseudo-Pelger Huet anomaly, a specific granulocyte morphological alteration.
Clinical Associations
- Notable causes of DIC include tissue trauma, obstetric complications, mucus-secreting tumors, acute infections, and snake bites.
- Promyelocytes in chronic myeloid conditions exhibit a dumbbell or bilobed nuclear shape, which is significant for recognizing Acute Promyelocytic Leukemia.
Summary of Definitions
- M0 to M7 designations represent progression and distinction within AML.
- Important terms like "Faggot cells," "Auer rods," and the morphological distinctions of promyelocytes are critical indicators used in diagnosis and classification of AML subtypes.
Studying That Suits You
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Description
Test your knowledge on the FAB classification of Acute Myeloid Leukemia (AML) with these flashcards. Each card covers different subtypes of AML, such as minimally differentiated and acute promyelocytic leukemia. Perfect for students and professionals in the medical field.
