Podcast
Questions and Answers
What is the typical time frame for obtaining knockout results using advanced VLPs?
What is the typical time frame for obtaining knockout results using advanced VLPs?
Which technology is NOT explicitly mentioned for genome editing?
Which technology is NOT explicitly mentioned for genome editing?
What benefits does the integration of AI and ML algorithms provide to gene editing and therapy?
What benefits does the integration of AI and ML algorithms provide to gene editing and therapy?
What is the focus of miRNA profiling and synthesis?
What is the focus of miRNA profiling and synthesis?
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Which of the following is an advantage of using advanced VLPs?
Which of the following is an advantage of using advanced VLPs?
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What type of cell line generation is noted as being time-consuming and expensive?
What type of cell line generation is noted as being time-consuming and expensive?
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What is a key feature of the mRNA production services mentioned?
What is a key feature of the mRNA production services mentioned?
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Which aspect of drug delivery and diagnostics is emphasized in the content?
Which aspect of drug delivery and diagnostics is emphasized in the content?
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Study Notes
VLPs for Vaccine Development
- Advanced VLPs for vaccines against Chikungunya, Dengue, and SARS-CoV-2 are offered.
Gene Therapy
- AAV1 and AAV9 are used in gene therapy applications.
Drug Screening
- Platforms for drug screening, focusing on SSTR2 and CCR5.
CRISPR Solutions
- CRISPR solutions for gene editing (knockouts, knock-ins, customized modifications) are available.
- Integrated multi-platform solutions for CRISPR sgRNA library synthesis and gene screening exist.
Oligonucleotide Synthesis
- Custom synthesis of oligonucleotides, primers, and probes for gene editing, PCR, and RNA studies.
miRNA Profiling and Studies
- miRNA profiling, synthesis, and delivery services for gene regulation studies and therapies.
Custom Libraries
- Custom cDNA, genomic, and mutagenesis libraries for drug discovery, screening, and functional genomics.
Microbial Productivity Enhancement
- Advanced genome editing (Rec-mediated recombination and CRISPR/Cas9) to enhance microbial productivity.
Drug Delivery and Diagnostics
- Next-generation aptamer selection and synthesis technologies for drug delivery and diagnostic development.
Cell Line Development
- Stable cell line expression over 15 generations supported.
- Rapid (3-month) cell line development for adherent and suspension cells (MCB, WCB, PCB).
mRNA Production
- Scalable mRNA production (milligrams to grams).
- Personalized process design for sequence optimization, cap selection, and nucleotide modification.
Plasmid Production
- Non-GMP, GMP-Like, and GMP-Grade plasmid production.
- Specialized options for linearized plasmids.
Viral Vector Production
- Advanced platforms for AAV, adenovirus, lentivirus, and retrovirus production adhering to GMP guidelines.
AI-Driven Gene Editing and Therapy
- AI and ML algorithms enhance antibody screening and predict new structures for antibody engineering.
- Proprietary datasets and Deep Learning models drive high-throughput enzyme activity testing for precise enzyme engineering.
Stable Cell Lines
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Stable cell lines for gene over-expression or knock-down are useful for gene analysis, target discovery, and compound screening.
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Stable cell lines are generated through plasmid transfection/lentivirus transduction, selection, colony picking, expression, functional screening, verification (real-time qRT-PCR or Western blot).
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Creative Biogene has vast experience in generating various stable cell lines (knockout, overexpression, knockdown).
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Panoply™ cell products are also available.
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Description
Explore a range of advanced techniques in biotechnology, including VLPs for vaccine development, gene therapy with AAV, and CRISPR gene editing solutions. This quiz covers essential topics such as drug screening methods and miRNA profiling, among others, to highlight their applications in drug discovery and gene regulation. Test your knowledge on the latest innovations in this rapidly evolving field.
