16 Questions
What is the most common malignancy of childhood?
Acute lymphoblastic leukemia
Which type of leukemia is caused by an accumulation of lymphoblasts in the bone marrow?
Acute lymphoblastic leukemia
What are the clinical features of acute lymphoblastic leukemia a result of?
Organ infiltration
What condition may be revealed by fundal examination in acute lymphoblastic leukemia?
Papilledema
What does the disease called if lymph node or solid extra nodal masses predominate with < 20% blasts in the marrow?
Lymphoblastic lymphoma
Which genetic classification system is used to subclassify acute lymphoblastic leukemias according to the underlying genetic defect?
WHO (2008)
What is the most common symptom of chronic lymphocytic leukemia (CLL)?
Symmetrical enlargement of cervical, axillary, or inguinal lymph nodes
What is the male to female ratio in chronic lymphocytic leukemia (CLL)?
2:1
What is the characteristic feature of tumor cells in acute lymphoblastic leukemia (ALL)?
Variable numbers of blast cells
What is the treatment for tumor lysis syndrome in acute lymphoblastic leukemia (ALL)?
Support and prevention
What is revealed by biochemical tests in acute lymphoblastic leukemia (ALL)?
Raised serum uric acid
What is a characteristic feature of hypodiploid (T-cells) cases in acute lymphoblastic leukemia (ALL)?
< 44 chromosomes
In chronic lymphocytic leukemia (CLL), where do the accumulated B cells predominantly appear?
Blood, bone marrow, liver, spleen, and lymph nodes
What type of B cell is the tumor cell in chronic lymphocytic leukemia (CLL)?
Mature B cell with weak surface expression of immunoglobulin (IgM or IgD)
What is the most common age group for the occurrence of chronic lymphocytic leukemia (CLL)?
> 50 years
What is an important consequence of chronic lymphocytic leukemia (CLL) leading to increased susceptibility to infections?
Hypogammaglobulinemia and cellular immune dysfunction
Test your knowledge on the classification and clinical features of Acute Lymphoblastic Leukemia (ALL), the most common malignancy of childhood. Understand the subtypes based on genetic defects and the clinical manifestations such as bone marrow failure and anemia.
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