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Questions and Answers
Which of the following are trade names for Acetylcysteine?
Which of the following are trade names for Acetylcysteine?
What is the drug class for Acetylcysteine?
What is the drug class for Acetylcysteine?
Acetaminophen antidote; amino acid mucolytic agent
What is the mechanism of action for Acetylcysteine?
What is the mechanism of action for Acetylcysteine?
Lowers mucus viscosity; restores glutathione concentrations in the liver
What are the indications for using Acetylcysteine?
What are the indications for using Acetylcysteine?
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What are the contraindications of Acetylcysteine?
What are the contraindications of Acetylcysteine?
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Which of the following are adverse side effects of Acetylcysteine? (Select all that apply)
Which of the following are adverse side effects of Acetylcysteine? (Select all that apply)
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What drug interacts with Acetylcysteine?
What drug interacts with Acetylcysteine?
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The loading dose of Acetylcysteine is ____ mg/kg IV.
The loading dose of Acetylcysteine is ____ mg/kg IV.
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What is the duration of Acetylcysteine?
What is the duration of Acetylcysteine?
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Study Notes
Acetylcysteine Overview
- Trade names include Mucomyst and Acetadote.
- Classified as an acetaminophen antidote and amino acid mucolytic agent.
Mechanism of Action
- Lowers mucus viscosity, making it easier to expel.
- Restores glutathione concentrations in the liver, aiding detoxification.
Indications
- Primarily used for acetaminophen overdose.
- Also indicated for atelectasis (lung collapse), bronchopulmonary disease, and tracheostomy care.
Contraindications
- Not recommended for individuals with acute asthma or hypersensitivity to the drug.
- Slower administration of the loading dose over 60 minutes can reduce risk of hypersensitivity reactions.
Adverse Effects
- Common side effects include diarrhea, nausea, and vomiting.
- May also lead to decreased cardiac function, hypervolemia, seizures, bronchospasm, and respiratory distress.
- Other potential effects include flushing, tachycardia, rash, and itching.
Drug Interactions
- Acetylcysteine may interact with nitroglycerine, necessitating caution when used together.
Dosage Information
- In cases of overdose, the regimen includes 300 mg/kg IV in three doses administered sequentially.
- Continuous infusion involves lower doses: 150 mg/kg over 1 hour, 50 mg/kg over 4 hours, and 100 mg/kg over 16 hours.
- For respiratory issues, 1-10 mL of a 10%-20% solution can be administered by nebulizer.
Duration of Action
- Onset of action is extremely fast at 1 minute.
- Peak effectiveness is reached within 5-15 minutes, lasting for approximately 100 minutes.
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Description
Test your knowledge about Acetylcysteine with these flashcards. Learn about its trade names, drug class, mechanism of action, and indications. Perfect for pharmacy students and healthcare professionals.
