Acetylcysteine Overview Flashcards
9 Questions
100 Views

Acetylcysteine Overview Flashcards

Created by
@CalmingCornet

Podcast Beta

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following are trade names for Acetylcysteine?

  • Acetadote (correct)
  • Tylenol
  • Ibuprofen
  • Mucomyst (correct)
  • What is the drug class for Acetylcysteine?

    Acetaminophen antidote; amino acid mucolytic agent

    What is the mechanism of action for Acetylcysteine?

    Lowers mucus viscosity; restores glutathione concentrations in the liver

    What are the indications for using Acetylcysteine?

    <p>Acetaminophen overdose, atelectasis, bronchopulmonary disease, tracheostomy care</p> Signup and view all the answers

    What are the contraindications of Acetylcysteine?

    <p>Acute asthma; hypersensitivity to the drug</p> Signup and view all the answers

    Which of the following are adverse side effects of Acetylcysteine? (Select all that apply)

    <p>Nausea</p> Signup and view all the answers

    What drug interacts with Acetylcysteine?

    <p>Nitroglycerine</p> Signup and view all the answers

    The loading dose of Acetylcysteine is ____ mg/kg IV.

    <p>300</p> Signup and view all the answers

    What is the duration of Acetylcysteine?

    <p>Onset: 1 min; Peak: 5-15 min; Duration: 100 min</p> Signup and view all the answers

    Study Notes

    Acetylcysteine Overview

    • Trade names include Mucomyst and Acetadote.
    • Classified as an acetaminophen antidote and amino acid mucolytic agent.

    Mechanism of Action

    • Lowers mucus viscosity, making it easier to expel.
    • Restores glutathione concentrations in the liver, aiding detoxification.

    Indications

    • Primarily used for acetaminophen overdose.
    • Also indicated for atelectasis (lung collapse), bronchopulmonary disease, and tracheostomy care.

    Contraindications

    • Not recommended for individuals with acute asthma or hypersensitivity to the drug.
    • Slower administration of the loading dose over 60 minutes can reduce risk of hypersensitivity reactions.

    Adverse Effects

    • Common side effects include diarrhea, nausea, and vomiting.
    • May also lead to decreased cardiac function, hypervolemia, seizures, bronchospasm, and respiratory distress.
    • Other potential effects include flushing, tachycardia, rash, and itching.

    Drug Interactions

    • Acetylcysteine may interact with nitroglycerine, necessitating caution when used together.

    Dosage Information

    • In cases of overdose, the regimen includes 300 mg/kg IV in three doses administered sequentially.
    • Continuous infusion involves lower doses: 150 mg/kg over 1 hour, 50 mg/kg over 4 hours, and 100 mg/kg over 16 hours.
    • For respiratory issues, 1-10 mL of a 10%-20% solution can be administered by nebulizer.

    Duration of Action

    • Onset of action is extremely fast at 1 minute.
    • Peak effectiveness is reached within 5-15 minutes, lasting for approximately 100 minutes.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Test your knowledge about Acetylcysteine with these flashcards. Learn about its trade names, drug class, mechanism of action, and indications. Perfect for pharmacy students and healthcare professionals.

    More Like This

    Acetylcysteine Quiz
    10 questions

    Acetylcysteine Quiz

    RightfulRainforest avatar
    RightfulRainforest
    Acetylcysteine Flashcards
    10 questions
    Acetylcysteine: Uses and Dosage
    9 questions

    Acetylcysteine: Uses and Dosage

    WellReceivedSquirrel7948 avatar
    WellReceivedSquirrel7948
    Use Quizgecko on...
    Browser
    Browser