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Questions and Answers
Which of the following are trade names for Acetylcysteine?
What is the drug class for Acetylcysteine?
Acetaminophen antidote; amino acid mucolytic agent
What is the mechanism of action for Acetylcysteine?
Lowers mucus viscosity; restores glutathione concentrations in the liver
What are the indications for using Acetylcysteine?
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What are the contraindications of Acetylcysteine?
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Which of the following are adverse side effects of Acetylcysteine? (Select all that apply)
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What drug interacts with Acetylcysteine?
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The loading dose of Acetylcysteine is ____ mg/kg IV.
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What is the duration of Acetylcysteine?
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Study Notes
Acetylcysteine Overview
- Trade names include Mucomyst and Acetadote.
- Classified as an acetaminophen antidote and amino acid mucolytic agent.
Mechanism of Action
- Lowers mucus viscosity, making it easier to expel.
- Restores glutathione concentrations in the liver, aiding detoxification.
Indications
- Primarily used for acetaminophen overdose.
- Also indicated for atelectasis (lung collapse), bronchopulmonary disease, and tracheostomy care.
Contraindications
- Not recommended for individuals with acute asthma or hypersensitivity to the drug.
- Slower administration of the loading dose over 60 minutes can reduce risk of hypersensitivity reactions.
Adverse Effects
- Common side effects include diarrhea, nausea, and vomiting.
- May also lead to decreased cardiac function, hypervolemia, seizures, bronchospasm, and respiratory distress.
- Other potential effects include flushing, tachycardia, rash, and itching.
Drug Interactions
- Acetylcysteine may interact with nitroglycerine, necessitating caution when used together.
Dosage Information
- In cases of overdose, the regimen includes 300 mg/kg IV in three doses administered sequentially.
- Continuous infusion involves lower doses: 150 mg/kg over 1 hour, 50 mg/kg over 4 hours, and 100 mg/kg over 16 hours.
- For respiratory issues, 1-10 mL of a 10%-20% solution can be administered by nebulizer.
Duration of Action
- Onset of action is extremely fast at 1 minute.
- Peak effectiveness is reached within 5-15 minutes, lasting for approximately 100 minutes.
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Description
Test your knowledge about Acetylcysteine with these flashcards. Learn about its trade names, drug class, mechanism of action, and indications. Perfect for pharmacy students and healthcare professionals.