Week 9 Quiz: Glycoproteins - Fnd Foundations of Med 2 PDF

12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 Due Dec 6 at 10:59pm Points 10 Questions 10 Available until Dec 6 at 10:59pm Time Limit None Allowed Attempts 3 Instructions Week 9 Workshop: Glycoproteins  Quiz Instructions Take the quiz to assess your knowle...

12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 Due Dec 6 at 10:59pm Points 10 Questions 10 Available until Dec 6 at 10:59pm Time Limit None Allowed Attempts 3 Instructions Week 9 Workshop: Glycoproteins  Quiz Instructions Take the quiz to assess your knowledge of the content for this session. You have 3 attempts. Your highest score will be recorded. Learning Objectives This activity enables you to meet the following learning objectives: 1. Describe the two groups of glycoproteins – the O-linked attached glycosidically to OH groups in Ser or Thr (rarely Tyr, HPr or HLy) and the N-linked attached to the amide group of Asn. 2. Discuss the locations where glycoproteins are found and their general structure and properties. 3. Discuss the types of sugar molecules found in glycoproteins. 4. Describe and contrast the processes whereby sugars are attached to either Ser/Thr residues (O-glycosylation) or Asn (N-glycosylation). 5. Identify dolichol phosphate as a product of the HMGCoA reductase pathway and as a lipid anchor for glycan synthesis. 6. Identify common glycan structures on glycoproteins. 7. Describe how glycan structures are used as recognition sites in inflammation, infection etc. 8. Describe the role of glycans in determining the antigenicity of red blood cells. https://rossmed.instructure.com/courses/3253/quizzes/17871 1/9 12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 9. Describe how newly synthesized glycoproteins are sorted and trafficked by the golgi apparatus, including membrane, secreted and lysosomal proteins. 10. Describe the natural history of inclusion cell (I-cell) disease. Due Date By 11:59 p.m. on Wednesday of Week 14 Grading Each quiz question is worth 1 point. This quiz grade is part of the Canvas Quizzes group, which is 3% of your grade for this module. This quiz was locked Dec 6 at 10:59pm. Attempt History Attempt Time Score KEPT Attempt 2 7 minutes 10 out of 10 LATEST Attempt 3 46,209 minutes 0 out of 10 Attempt 2 7 minutes 10 out of 10 Attempt 1 37 minutes 6 out of 10 Score for this attempt: 0 out of 10 Submitted Dec 6 at 10:59pm This attempt took 46,209 minutes. Unanswered Question 1 https://rossmed.instructure.com/courses/3253/quizzes/17871 0 / 1 pts 2/9 12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 An 8-month-old boy with coarse facial features, skeletal abnormalities, and delays in both growth and development is diagnosed with I-cell disease based on his presentation and on histologic and biochemical testing. I-cell disease is characterized by Correct Answer Elevated levels of acid hydrolases in the blood An inability to N-glycosylate proteins Oligosaccharides in the urine Increased synthesis of proteoglycans Decreased production of cell-surface O-linked glycoproteins Unanswered Question 2 0 / 1 pts All cells have a glycocalyx, which contains sugar molecules on the outer surface of the cell plasma membrane. Which of the following is an important component contributing to the glycocalyx? Glycerophospholipids Correct Answer Glycoproteins https://rossmed.instructure.com/courses/3253/quizzes/17871 3/9 12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 Heptahelical receptors Glycogen molecules Unanswered Question 3 0 / 1 pts A 19-year-old man is seen by you with a chest infection. He admits to coughing frequently and bringing up liberal quantities of green slimy, slippery phlegm. After your examination, you reach for your pad to write a prescription for an antibiotic and then you recall that phlegm is a mixture of mucus, bacteria and sloughed epithelial cells. Its slipperiness is due to mucin, a glycoprotein with large amounts of Phosphorylated sugars Glucuronic or iduronic acids Correct Answer Sialic acid (NANA) N-linked high mannose chains Sulfated sugars Unanswered Question 4 https://rossmed.instructure.com/courses/3253/quizzes/17871 0 / 1 pts 4/9 12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 Mucopolysaccharidoses are hereditary lysosomal storage diseases. What is the most important underlying cause of these diseases? An increased rate of synthesis of the carbohydrate component of proteoglycans Defects in the targeting of enzymes to lysosomes An insufficient rate of synthesis of proteolytic enzymes The synthesis of abnormally small amounts of core proteins Correct Answer Defects in the degradation of glycosaminoglycans The synthesis of heteropolysaccharides with an altered structure Unanswered Question 5 0 / 1 pts In I-cell disease or mucolipidosis type II, all of the lysosomal enzymes are missing from the lysosomes within the cells of connective tissue. The defect is caused by https://rossmed.instructure.com/courses/3253/quizzes/17871 5/9 12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 GDP-mannose pyrophosphorylase deficiency Mannose 6-phosphate isomerase hyperactivity Correct Answer Inability to phosphorylate mannose residues Mannose kinase deficiency Unanswered Question 6 0 / 1 pts Which of the following is found in connective tissues? Glycosaminoglycans Glycoproteins Correct Answer Proteoglycans Glycolipids Unanswered Question 7 0 / 1 pts Which of the following statements is false about proteoglycans? Chondroitin sulfate is a proteoglycan https://rossmed.instructure.com/courses/3253/quizzes/17871 6/9 12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 Correct Answer They hold less amount of water They are made of amino acids and sugars They possess charge Unanswered Question 8 0 / 1 pts On which surface(s) of the cell membrane are the carbohydrate part of glycoproteins or glycolipids found? Inside Both outside and inside Correct Answer Outside Neither side Question 9 0 / 1 pts Which of the following is a characteristic sugar residue always found in N-linked glycoproteins, but hardly ever in O-linked glycoproteins? https://rossmed.instructure.com/courses/3253/quizzes/17871 7/9 12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 Sorbitol Correct Answer Mannose Fructose Ribose Xylose You Answered Unanswered Galactose Question 10 0 / 1 pts The low-density lipoprotein receptor has a domain containing O-linked glycan chains. How are the sequences of the sugar residues determined? Editing the sugar sequences to replace sugars in the wrong position Correct Answer Having a large number of very specific glycosyltranferases Controlling the availability of the different activated sugars https://rossmed.instructure.com/courses/3253/quizzes/17871 8/9 12/9/23, 3:55 PM Week 9: Quiz | Workshop: Glycoproteins: Fund Foundations of Med 2 Matching against a carbohydrate template in the ER Quiz Score: 0 out of 10 https://rossmed.instructure.com/courses/3253/quizzes/17871 9/9