Glycoproteins and Medical Conditions Quiz

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Questions and Answers

Which group of glycoproteins is O-linked attached to OH groups in Ser or Thr (rarely Tyr, HPr or HLy)?

C-linked glycoproteins

N-linked glycoproteins

M-linked glycoproteins (correct)

P-linked glycoproteins

Where are glycoproteins found and what are their general structure and properties?

Found in the endoplasmic reticulum, linear structure, and hydrophilic properties

Found in the cell membrane, branched structure, and hydrophobic properties (correct)

Found in the cytoplasm, linear structure, and hydrophobic properties

Found in the nucleus, branched structure, and hydrophilic properties

What are the types of sugar molecules found in glycoproteins?

Ribose, deoxyribose, and cellulose

Glucose, fructose, and sucrose

Monosaccharides, disaccharides, and polysaccharides

Galactose, mannose, and sialic acid (correct)

How are sugars attached to either Ser/Thr residues (O-glycosylation) or Asn (N-glycosylation)?

O-glycosylation occurs in the Golgi apparatus, while N-glycosylation occurs in the endoplasmic reticulum Signup and view all the answers

What is dolichol phosphate's role in glycan synthesis?

It is a lipid anchor for glycan synthesis Signup and view all the answers

What do common glycan structures on glycoproteins help identify?

Recognition sites in inflammation and infection Signup and view all the answers

How do glycans contribute to determining the antigenicity of red blood cells?

They mask the antigenic sites on red blood cells Signup and view all the answers

What is the main characteristic of I-cell disease?

Inability to phosphorylate mannose residues Signup and view all the answers

What is the main reason for the slipperiness of phlegm?

Large amounts of sialic acid (NANA) Signup and view all the answers

What are mucopolysaccharidoses primarily caused by?

Defects in the degradation of glycosaminoglycans Signup and view all the answers

Where is the carbohydrate part of glycoproteins or glycolipids found?

On the outside of the cell membrane Signup and view all the answers

Which sugar residue is characteristic of N-linked glycoproteins?

Mannose Signup and view all the answers

What determines the sequences of the sugar residues on the low-density lipoprotein receptor?

Specific glycosyltransferases Signup and view all the answers

What do connective tissues contain?

Proteoglycans, glycosaminoglycans, and glycoproteins Signup and view all the answers

What are proteoglycans made of?

Amino acids and sugars Signup and view all the answers

Study Notes

Glycoproteins: Fund Foundations of Med 2 Quiz Summary

I-cell disease is characterized by elevated levels of acid hydrolases in the blood
All cells have a glycocalyx containing sugar molecules on the outer surface of the cell plasma membrane, with glycoproteins being an important component
The slipperiness of phlegm is due to mucin, a glycoprotein with large amounts of sialic acid (NANA)
Mucopolysaccharidoses are hereditary lysosomal storage diseases caused by defects in the degradation of glycosaminoglycans
In I-cell disease, the missing lysosomal enzymes are due to an inability to phosphorylate mannose residues
Connective tissues contain proteoglycans, glycosaminoglycans, and glycoproteins
Proteoglycans are not made of amino acids and sugars, and they possess a charge
The carbohydrate part of glycoproteins or glycolipids is found on the outside of the cell membrane
Mannose is a characteristic sugar residue always found in N-linked glycoproteins, but hardly ever in O-linked glycoproteins
The sequences of the sugar residues on the low-density lipoprotein receptor are determined by having a large number of very specific glycosyltransferases
The quiz was worth 10 points, and the score for the latest attempt was 0 out of 10
The quiz was part of the Canvas Quizzes group, which is 3% of the grade for the module

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Description

Test your knowledge of glycoproteins and their role in various medical conditions with this quiz. Explore topics such as I-cell disease, mucopolysaccharidoses, and the composition of connective tissues.