15 Questions
Which group of glycoproteins is O-linked attached to OH groups in Ser or Thr (rarely Tyr, HPr or HLy)?
M-linked glycoproteins
Where are glycoproteins found and what are their general structure and properties?
Found in the cell membrane, branched structure, and hydrophobic properties
What are the types of sugar molecules found in glycoproteins?
Galactose, mannose, and sialic acid
How are sugars attached to either Ser/Thr residues (O-glycosylation) or Asn (N-glycosylation)?
O-glycosylation occurs in the Golgi apparatus, while N-glycosylation occurs in the endoplasmic reticulum
What is dolichol phosphate's role in glycan synthesis?
It is a lipid anchor for glycan synthesis
What do common glycan structures on glycoproteins help identify?
Recognition sites in inflammation and infection
How do glycans contribute to determining the antigenicity of red blood cells?
They mask the antigenic sites on red blood cells
What is the main characteristic of I-cell disease?
Inability to phosphorylate mannose residues
What is the main reason for the slipperiness of phlegm?
Large amounts of sialic acid (NANA)
What are mucopolysaccharidoses primarily caused by?
Defects in the degradation of glycosaminoglycans
Where is the carbohydrate part of glycoproteins or glycolipids found?
On the outside of the cell membrane
Which sugar residue is characteristic of N-linked glycoproteins?
Mannose
What determines the sequences of the sugar residues on the low-density lipoprotein receptor?
Specific glycosyltransferases
What do connective tissues contain?
Proteoglycans, glycosaminoglycans, and glycoproteins
What are proteoglycans made of?
Amino acids and sugars
Study Notes
Glycoproteins: Fund Foundations of Med 2 Quiz Summary
- I-cell disease is characterized by elevated levels of acid hydrolases in the blood
- All cells have a glycocalyx containing sugar molecules on the outer surface of the cell plasma membrane, with glycoproteins being an important component
- The slipperiness of phlegm is due to mucin, a glycoprotein with large amounts of sialic acid (NANA)
- Mucopolysaccharidoses are hereditary lysosomal storage diseases caused by defects in the degradation of glycosaminoglycans
- In I-cell disease, the missing lysosomal enzymes are due to an inability to phosphorylate mannose residues
- Connective tissues contain proteoglycans, glycosaminoglycans, and glycoproteins
- Proteoglycans are not made of amino acids and sugars, and they possess a charge
- The carbohydrate part of glycoproteins or glycolipids is found on the outside of the cell membrane
- Mannose is a characteristic sugar residue always found in N-linked glycoproteins, but hardly ever in O-linked glycoproteins
- The sequences of the sugar residues on the low-density lipoprotein receptor are determined by having a large number of very specific glycosyltransferases
- The quiz was worth 10 points, and the score for the latest attempt was 0 out of 10
- The quiz was part of the Canvas Quizzes group, which is 3% of the grade for the module
Test your knowledge of glycoproteins and their role in various medical conditions with this quiz. Explore topics such as I-cell disease, mucopolysaccharidoses, and the composition of connective tissues.
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